Retrovirus Vectors for Gene Transfer: Efficient Integration into and Expression of Exogenous DNA in Vertebrate Cell Genomes

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Production of transgenic rabbits, sheep and pigs by microinjection

1985 • 1,063 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Die Molekularbiologie der Tumorviren

1977 • 951 citations

Ty elements transpose through an RNA intermediate

1985 • 837 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA

1982 • 668 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Form and Function of Retroviral Proviruses

1982 • 627 citations

Genetic engineering in Vivo using translocatable drug-resistance elements

1977 • 625 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

1984 • 440 citations

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

1984 • 407 citations

Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

1984 • 368 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene.

1985 • 342 citations

Complete Nucleotide Sequence of the Drosophila Transposable Element Copia: Homology Between Copia and Retroviral Proteins

1985 • 299 citations

Gene Expression in Mice After High Efficiency Retroviral-Mediated Gene Transfer

1985 • 281 citations

Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

1981 • 254 citations

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

1981 • 253 citations

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

1981 • 250 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Structure, variation and synthesis of retrovirus long terminal repeat

1981 • 236 citations

Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

1984 • 229 citations

Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors.

1983 • 214 citations

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells

1983 • 214 citations

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT.

1983 • 208 citations

Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.

1985 • 206 citations

The terminal nucleotides of retrovirus DNA are required for integration but not virus production

1983 • 193 citations

Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs

1983 • 191 citations

Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins.

1985 • 190 citations

Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene.

1982 • 190 citations

Expression of a Retrovirus Encoding Human HPRT in Mice

1984 • 182 citations

The Infidelity of Avian Myeloblastosis Virus Deoxyribonucleic Acid Polymerase in Polynucleotide Replication

1974 • 172 citations

Reverse transcription in the eukaryotic genome: retroviruses, pararetroviruses, retrotransposons, and retrotranscripts.

1985 • 166 citations

Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs

1985 • 165 citations

Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.

1982 • 157 citations

High mutation rate of a spleen necrosis virus-based retrovirus vector.

1986 • 157 citations

Quantitative analysis of gene suppression in integrated retrovirus vectors.

1986 • 155 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.

1982 • 150 citations

High-Efficiency Ligation and Recombination of DNA Fragments by Vertebrate Cells

1983 • 148 citations

Function of the retrovirus long terminal repeat

1982 • 148 citations

Insertion Mutagenesis of Embryonal Carcinoma Cells by Retroviruses

1985 • 132 citations

Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector

1984 • 121 citations

Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection

1984 • 121 citations

Amphotropic retrovirus vector system for human cell gene transfer.

1984 • 117 citations

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1984 • 110 citations

Human Gene Therapy: Scientific and Ethical Considerations

1985 • 110 citations

Loss of intervening sequences in genomic mouse α-globin DNA inserted in an infectious retrovirus vector

1982 • 107 citations

Evolution of influenza virus genes.

1985 • 104 citations

Malignant Transformation of Erythroid Cells in Vivo by Introduction of a Nonreplicating Retrovirus Vector

1985 • 103 citations

At least four viral genes contribute to the leukemogenicity of murine retrovirus MCF 247 in AKR mice

1985 • 102 citations

Infectious and Selectable Retrovirus Containing an Inducible Rat Growth Hormone Minigene

1984 • 99 citations

Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus

1980 • 99 citations

Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection.

1985 • 98 citations

High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters

1984 • 96 citations

Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.

1984 • 96 citations

Transfer of genes into embryonal carcinoma cells by retrovirus infection: efficient expression from an internal promoter.

1985 • 94 citations

Secretion of human parathyroid hormone from rat pituitary cells infected with a recombinant retrovirus encoding preproparathyroid hormone.

1984 • 92 citations

Replication-competent Moloney murine leukemia virus carrying a bacterial suppressor tRNA gene: selective cloning of proviral and flanking host sequences.

1985 • 88 citations

Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector.

1984 • 88 citations

Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity

1985 • 77 citations

Retroviral DNA integration

1985 • 76 citations

Substitution of 5′ helper virus sequences into non-rel portion of reticuloendotheliosis virus strain T suppresses transformation of chicken spleen cells

1982 • 75 citations

A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens

1983 • 69 citations

Cell-specified expression of a selectable hybrid gene.

1984 • 69 citations

Requirement for a Signal Sequence in Biological Expression of the v- sis Oncogene

1984 • 69 citations

VARIATION IN AVIAN RETROVIRUS GENOMES*

1980 • 67 citations

Construction of a retrovirus capable of transducing and expressing genes in multipotential embryonic cells.

1984 • 66 citations

Enhancer activity correlates with the oncogenic potential of avian retroviruses.

1985 • 64 citations

Spontaneous changes in nucleotide sequence in proviruses of spleen necrosis virus, an avian retrovirus.

1982 • 63 citations

Role of intron-contained sequences in formation of moloney murine leukemia virus env mRNA.

1984 • 62 citations

Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.

1983 • 61 citations

Slow virus visna: reproduction in vitro of virus from extrachromosomal DNA.

1984 • 61 citations

Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus

1984 • 59 citations

Infectious and noninfectious recombinant clones of the provirus of SNV differ in cellular DNA and are apparently the same in viral DNA

1980 • 59 citations

HTLVx-Gene Product: Requirement for theenvMethionine Initiation Codon

1985 • 59 citations

Activation of oncogenicity of the c-rel proto-oncogene.

1986 • 57 citations

Splicing of intervening sequences introduced into an infectious retroviral vector.

1982 • 57 citations

Design of a Retrovirus-Derived Vector for Expression and Transduction of Exogenous Genes in Mammalian Cells

1983 • 56 citations

Retroviral-mediated gene transfer of human phenylalanine hydroxylase into NIH 3T3 and hepatoma cells.

1986 • 55 citations

Recombination of transfected DNAs in vertebrate cells in culture.

1984 • 55 citations

Insertion of several different DNAs in reticuloendotheliosis virus strain T suppresses transformation by reducing the amount of subgenomic mRNA

1986 • 53 citations

Integration-specific retrovirus expression in embryonal carcinoma cells.

1984 • 53 citations

Comparison Between the Viral Transforming Gene (src) of Recovered Avian Sarcoma Virus and Its Cellular Homolog

1981 • 52 citations

Incorporation of noncomplementary nucleotides at high frequencies by ribodeoxyvirus DNA polymerases and Escherichia coli DNA polymerase I

1976 • 51 citations

Expression from an internal AUG codon of herpes simplex thymidine kinase gene inserted in a retrovirus vector.

1984 • 51 citations

Expression of complete chicken thymidine kinase gene inserted in a retrovirus vector.

1984 • 51 citations

Spontaneous variation and synthesis in the U3 region of the long terminal repeat of an avian retrovirus

1982 • 49 citations

Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.

1985 • 44 citations

Isolation of embryonal carcinoma cell lines that express integrated recombinant genes flanked by the Moloney murine leukemia virus long terminal repeat.

1985 • 40 citations

Construction and Recovery of Viable Retroviral Genomes Carrying a Bacterial Suppressor Transfer RNA Gene

1985 • 39 citations

Viral transfer, transcription, and rescue of a selectable myeloproliferative sarcoma virus in embryonal cell lines: expression of the mos oncogene.

1986 • 37 citations

Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus.

1986 • 37 citations

An unusual 5' splice sequence is efficiently utilized in vivo.

1984 • 37 citations

Expression of human adenosine deaminase using a transmissable murine retrovirus vector system.

1985 • 36 citations

Office of Technology Assessment

1988 • 36 citations

Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences

1985 • 33 citations

Recombinant DNA Research and Viruses

1985 • 29 citations

The Location of v-src in a Retrovirus Vector Determines Whether the Virus Is Toxic or Transforming

1984 • 28 citations

Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog.

1981 • 28 citations

Comparison of the transcriptional properties of the friend and moloney retrovirus long terminal repeats: Importance of tandem duplications and of the core enhancer sequence

1985 • 28 citations

Roles of helper and defective retroviral genomes in murine erythroleukemia: studies of spleen focus-forming virus in the absence of helper

1985 • 26 citations

Introduction of sequences encoding functional human adenosine deaminase into mouse cells using a retroviral shuttle system

1985 • 24 citations

Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker.

1984 • 22 citations

Characterization of a retrovirus shuttle vector capable of either proviral integration or extrachromosomal replication in mouse cells.

1985 • 21 citations

Suppression of multiplication of avian sarcoma virus by rapid spread of transformation-defective virus of the same subgroup

1979 • 13 citations

The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming.

1984 • 12 citations

Developments in Molecular Virology: Cloning of Retrovirus DNA in Bacteria and Cloning of other DNA in Retroviruses

1985 • 3 citations