Origin, structure and motifs of naturally processed MHC class II ligands

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Searching for Peptide Ligands with an Epitope Library

1990 • 2,080 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Random Peptide Libraries: a Source of Specific Protein Binding Molecules

1990 • 910 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Evolution of the major histocompatibility complex.

1986 • 326 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

1994 • 234 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

1992 • 174 citations

Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway

1991 • 171 citations

HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.

1993 • 154 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Evolution of the major histocompatibility complex

1986 • 142 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment.

1993 • 124 citations

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

1993 • 123 citations

Consensus motifs and peptide ligands of MHC class I molecules

1993 • 118 citations

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86

1993 • 107 citations

Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.

1992 • 105 citations

Intracellular traffic and antigen processing

1989 • 92 citations

Peptide motifs of HLA-B35 and-B37 molecules

1993 • 88 citations

MHC molecules protect T cell epitopes against proteolytic destruction.

1992 • 87 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

Truncation analysis of several DR binding epitopes.

1991 • 76 citations

Cellular studies on antigen presentation by class II MHC molecules

1992 • 75 citations

Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules

1993 • 73 citations

Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis

1993 • 72 citations

Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides.

1993 • 63 citations

Conformational and structural characteristics of peptides binding to HLA-DR molecules.

1991 • 62 citations

Membrane-bound peptidases of lymphocytes: functional implications.

1991 • 50 citations

Determinant Protection. A Hypothesis for the Activity of Immune Response Genes in the Processing and Presentation of Antigens by Macrophages

1986 • 40 citations

Self-peptides from four HLA-DR alleles share hydrophobic anchor residues near the NH2-terminal including proline as a stop signal for trimming.

1993 • 39 citations

Chemistry of peptide interactions with MHC proteins

1992 • 39 citations

Endogenous secretion of IL-4 maintains growth and Thy-1 expression of a transformed B cell clone.

1993 • 11 citations