Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total P_i

10 Methoden der enzymatischen Analyse

2019 • 3,602 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

Cellular Energy Metabolism and its Regulation

1977 • 961 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

1991 • 349 citations

Tumor tissue oxygenation as evaluated by computerized-po2-histography

1990 • 255 citations

The Use of Ranks in a Test of Significance for Comparing Two Treatments

1952 • 251 citations

31P NMR spectroscopy of in vivo tumors

1982 • 190 citations

Phosphorylation status of liver by 31P-n.m.r. spectroscopy, and its implications for metabolic control. A comparison of 31P-n.m.r. spectroscopy (in vivo and in vitro) with chemical and enzymic determinations of ATP, ADP and Pi

1985 • 174 citations

Drug Resistance in Oncology

1994 • 173 citations

Application ofin vivo NMR spectroscopy to cancer

1984 • 148 citations

An assessment of ³¹P MRS as a method of measuring pH in rat tumours

1992 • 146 citations

Regulation of cellular metabolism by intracellular phosphate

1977 • 134 citations

Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice

1992 • 132 citations

Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma.

1989 • 126 citations

Tumor size dependent changes in a murine fibrosarcoma: Use of in vivo31P NMR for non-invasive evaluation of tumor metabolic status

1986 • 112 citations

Correlations between 31 P-NMR Spectroscopy and Tissue O 2 Tension Measurements in a Murine Fibrosarcoma

1989 • 97 citations

31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia.

1988 • 88 citations

Effects of Hydralazine-Induced Vasodilation on the Energy Metabolism of Murine Tumors Studied by In Vivo31P-Nuclear Magnetic Resonance Spectroscopy1

1988 • 83 citations

Metabolic Imaging in Microregions of Tumors and Normal Tissues With Bioluminescence and Photon Counting

1988 • 83 citations

The application of nuclear magnetic resonance to the study of cellular physiology

1984 • 72 citations

Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat

1985 • 69 citations

The contribution made by cell death and oxygenation to ³¹P MRS observations of tumour energy metabolism

1992 • 56 citations

Physiological properties of malignant tumours

1992 • 56 citations

A hypothesis: Noncyclic phosphodiesters may play a role in membrane control

1984 • 52 citations

ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence.

1990 • 52 citations

Size dependent changes in tumor phosphate metabolism after radiation therapy as detected by 31P NMR spectroscopy

1987 • 51 citations

Effects of Oxygen on the Metabolism of Murine Tumors Using in Vivo Phosphorus-31 NMR

1987 • 48 citations

A simple and inexpensive method for maintaining a defined flora mouse colony.

1977 • 47 citations

Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry.

1990 • 42 citations

In vivo³¹P-NMR spectroscopy of murine tumours before and after localized hyperthermia

1990 • 41 citations

Locust flight metabolism studied in vivo by 31P NMR spectroscopy

1991 • 40 citations

Estimation of tumor oxygenation and metabolic rate using 31P MRS: Correlation of longitudinal relaxation with tumor growth rate and dna synthesis

1988 • 38 citations

31P-nuclear magnetic resonance spectroscopy studies of the response of rat mammary tumors to endocrine therapy.

1988 • 37 citations

³¹P NMR Spectroscopyin Vivoof Two Murine Tumor Lines with Widely Different Fractions of Radiobiologically Hypoxic Cells

1988 • 37 citations

Characterization of the 31P nuclear magnetic resonance spectrum from human melanoma tumors implanted in nude mice.

1987 • 36 citations

Relationship between Energy Status, Hypoxic Cell Fraction, and Hyperthermic Sensitivity in a Murine Fibrosarcoma

1989 • 36 citations

Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia

1991 • 33 citations

Correlations between in vivo31P NMR spectroscopy measurements, tumor size, hypoxic fraction and cell survival after radiotherapy

1990 • 31 citations

Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia

1993 • 31 citations

Energy Metabolism and Blood Perfusion in a Mouse Mammary Adenocarcinoma during Growth and Following X Irradiation

1987 • 30 citations

Effects of Pentobarbital Anesthesia on the Energy Metabolism of Murine Tumors Studied by in Vivo 31 P Nuclear Magnetic Resonance Spectroscopy

1988 • 29 citations

Growth studies of subcutaneous rat tumours: comparison of 31P-NMR spectroscopy, acid extracts and histology

1989 • 28 citations

Phosphorylated Metabolites in Tumors, Tissues, and Cell Linesa

1987 • 26 citations

31P NMR spectroscopy measurements of human ovarian carcinoma xenografts: Relationship to tumour volume, growth rate, necrotic fraction and differentiation status

1988 • 26 citations

Changes in 31 P Nuclear Magnetic Resonance with Tumor Growth in Radioresistant and Radiosensitive Tumors

1990 • 24 citations

Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours

1992 • 24 citations

31P-NMR spectroscopy and histological studies of the response of rat mammary tumours to endocrine therapy

1990 • 20 citations

Comparative Imaging of Structure and Metabolites in Tumours

1991 • 19 citations

31P Surface-Coil NMR Analysis of Metabolic Status in KHJJ Tumors

1985 • 18 citations

Energy status in the murine FSaII and MCaIV tumors under aerobic and hypoxic conditions: An in-vivo and in-vitro analysis

1992 • 18 citations

Glycogen phosphorylase in fish muscle: demonstration of three interconvertible forms

1990 • 16 citations

Phosphorus Metabolites by NMR

1984 • 15 citations

31P NMR studies on recovery from hypoxia of human tumor cells

1987 • 7 citations