Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The metabolic and molecular bases of inherited disease

2001 • 6,883 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Altered wound healing in mice lacking a functional osteopontin gene (spp1).

1998 • 645 citations

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1997 • 545 citations

Isoform-specific binding of apolipoprotein E to beta-amyloid.

1994 • 529 citations

Apolipoprotein E

1999 • 373 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

1986 • 343 citations

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1999 • 340 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

Apo E structure determines VLDL clearance and atherosclerosis risk in mice

1999 • 302 citations

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.

1994 • 299 citations

Human Apolipoprotein E4 Domain Interaction

1996 • 293 citations

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

1997 • 291 citations

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

1990 • 289 citations

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

1988 • 285 citations

Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe^−/−Mice: Isoform-Specific Effects on Neurodegeneration

1999 • 283 citations

Nascent Astrocyte Particles Differ from Lipoproteins in CSF

1998 • 281 citations

Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

1995 • 258 citations

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.

1998 • 241 citations

Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

2000 • 238 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.

1998 • 218 citations

Apolipoprotein E and atherosclerosis: insight from animal and human studies

1999 • 214 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In.

1986 • 148 citations

Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase

1998 • 143 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins.

1989 • 114 citations

Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells.

1982 • 107 citations

Myf-5 Revisited

2000 • 105 citations

Amyloid β‐Protein, APOE Genotype and Head Injury

1996 • 100 citations

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

2000 • 98 citations

Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice

2000 • 92 citations

Altered wound healing in mice lacking a functional osteopontin gene (spp1).

1998 • 83 citations

Effects of ApoE Genotype on ApoB-48 and ApoB-100 Kinetics With Stable Isotopes in Humans

2000 • 51 citations

Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E.

1991 • 43 citations