Regulation of replicative senescence by insulin‐like growth factor‐binding protein 3 in human umbilical vein endothelial cells

The serial cultivation of human diploid cell strains

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

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Production of high-titer helper-free retroviruses by transient transfection.

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Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

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FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

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Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*

1996 • 1,078 citations

The signals and pathways activating cellular senescence

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

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Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

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Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

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Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

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Binding proteins for the insulin-like growth factors: Structure, regulation and function

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Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

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Growth hormone and the insulin-like growth factor system in myogenesis

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Insulin-like growth factor binding proteins and their role in controlling IGF actions

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Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

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Calorie restriction mimetics: an emerging research field

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The evolution of diverse biological responses to DNA damage: insights from yeast and p53

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Regulation of cellular senescence by p53

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Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis

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Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

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Triple Layer Control: Phosphorylation, Acetylation and Ubiquitination of FOXO Proteins

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Nuclear Import of Insulin-like Growth Factor-binding Protein-3 and -5 Is Mediated by the Importin β Subunit

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Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

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The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP

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Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

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Replicative senescence: a critical review

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Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53

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Insulin-like Growth Factor-I Extends in VitroReplicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3′-Kinase/Akt Signaling Pathway

2000 • 232 citations

Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis

2001 • 198 citations

The Role of Cellular Senescence in Skin Aging

1998 • 168 citations

The role of insulin and IGF-1 signaling in longevity

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Insulin-like Growth Factor (IGF)-binding Protein-3 Mutants That Do Not Bind IGF-I or IGF-II Stimulate Apoptosis in Human Prostate Cancer Cells

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The genetics of human longevity

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Nuclear Transport of Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Opossum Kidney Cells

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Differential regulation of apoptotic cell death in senescent human cells

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Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology

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Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

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Molecular genetics of life span in C. elegans: How much does it teach us?

1998 • 101 citations

What's new in the IGF-binding proteins?

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Down-Regulation of a Forkhead Transcription Factor, FOXO3a, Accelerates Cellular Senescence in Human Dermal Fibroblasts

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Identification of amyloid β-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid β-peptide toxicity

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The Role of Cellular Senescence in Skin Aging

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Post-transcriptional regulation of interleukin 1 alphain various strains of young and senescent human umbilical vein endothelialcells.

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Apoptosis resistance of senescent human fibroblasts is correlated with the absence of nuclear IGFBP‐3

2005 • 64 citations

p53-Dependent and p53-Independent Induction of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid Damage and Hypoxia

2005 • 55 citations

FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression

2005 • 53 citations

Nuclear Transport of Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Opossum Kidney Cells

1997 • 31 citations

Overexpression of Insulin-like Growth Factor Binding Protein-3 by Senescent Human Fibroblasts: Attenuation of the Mitogenic Response to IGF-I

1995 • 28 citations

IGFBP-3, a Marker of Cellular Senescence, Is Overexpressed in Human Papillomavirus-Immortalized Cervical Cells and Enhances IGF-1-Induced Mitogenesis

2004 • 27 citations

Characterization of a Novel Positive Transcription Regulatory Element That Differentially Regulates the Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Gene in Senescent Cells

2005 • 16 citations