Bypassing the antigen to control rheumatoid arthritis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1993 • 2,828 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

TWIN CONCORDANCE RATES FOR RHEUMATOID ARTHRITIS: RESULTS FROM A NATIONWIDE STUDY

1993 • 600 citations

Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

1994 • 531 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

1991 • 365 citations

Maternal-Fetal Disparity in HLA Class II Alloantigens and the Pregnancy-Induced Amelioration of Rheumatoid Arthritis

1993 • 359 citations

Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I

1991 • 344 citations

In vivo production of interleukin‐10 by non–t cells in rheumatoid arthritis, sjöugren's syndrome, and systemic lupus erythematosus.

1994 • 317 citations

Interferon gamma inhibits interleukin 10 production by monocytes.

1993 • 294 citations

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor

1995 • 236 citations

Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin‐4 in an ex vivo model of rheumatoid synovitis

1992 • 184 citations

Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis.

1993 • 173 citations

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

1994 • 134 citations

The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium.

1995 • 124 citations

Interleukin‐4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis

1994 • 107 citations

Recombinant interferon-γ in the treatment of systemic sclerosis

1989 • 104 citations

Immune ablation followed by allogeneic or autologous bone marrow transplantation: A new treatment for severe autoimmune diseases?

1994 • 102 citations

Thyroid dysfunction associated with immunotherapy for patients with cancer

1991 • 77 citations

Differential effects of interleukins 10 and 4 on the production of interleukin‐6 by blood and synovium monocytes in rheumatoid arthritis

1995 • 59 citations

IL-4 inhibits growth factor-stimulated rheumatoid synoviocyte proliferation by blocking the early phases of the cell cycle.

1993 • 54 citations

Different cytokine production profiles of γδ T cell clones: Relation to inflammatory arthritis

1994 • 48 citations

Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome

1989 • 48 citations

Absence of Lentiviral and Human T Cell Leukemia Viral Sequences in Patients with Rheumatoid Arthritis

1994 • 28 citations