Activation of p38 Mitogen-activated Protein Kinase by c-Abl-dependent and -independent Mechanisms

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Structural aspects of platinum anticancer drug interactions with DNA

1987 • 927 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

1992 • 242 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function.

1984 • 104 citations

Basic Radiobiology

1988 • 89 citations

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

1995 • 75 citations

Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase

1995 • 74 citations

Rac is required for v-Abl tyrosine kinase to activate mitogenesis

1996 • 74 citations

jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells.

1995 • 65 citations

Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.

1995 • 46 citations

Potentiation of alkylation-induced sister chromatid exchange frequency by 3-aminobenzamide is mediated by intracellular loss of NAD⁺

1986 • 18 citations

Impaired jun-NH2-terminal kinase activation by ultraviolet irradiation in fibroblasts of patients with Cockayne syndrome complementation group B.

1996 • 14 citations

Kinetics of cell death induced in 10T1/2 cells by methyl methanesulfonate and the effects of extracellular calcium on cell death.

1986 • 10 citations