Recovery of Ca2+ Pools and Growth in Ca2+Pool-depleted Cells Is Mediated by Specific Epoxyeicosatrienoic Acids Derived from Arachidonic Acid

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Capacitative calcium entry

1995 • 1,112 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Inflammation and the mechanism of action of anti‐inflammatory drugs

1987 • 523 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

1991 • 452 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

1990 • 310 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids.

1988 • 261 citations

Intracellular Ca2+ pool content is linked to control of cell growth.

1993 • 260 citations

Identification of intracellular calcium pools. Selective modification by thapsigargin

1991 • 238 citations

Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum.

1992 • 234 citations

Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth.

1991 • 206 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

GTP-activated communication between distinct inositol 1,4,5-trisphosphate-sensitive and -insensitive calcium pools

1989 • 202 citations

Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

1977 • 196 citations

The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase

1983 • 190 citations

Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis

1995 • 134 citations

The effect of 5,8,11,14‐eicosatetraynoic acid on lipid metabolism

1979 • 134 citations

Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores

1995 • 126 citations

Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.

1991 • 125 citations

Calcium binding proteins in the sarcoplasmic/endoplasmic reticulum of muscle and nonmuscle cells

1992 • 117 citations

Selective Inhibition of Prostaglandin Endoperoxide Synthase-1 (Cyclooxygenase-1) by Valerylsalicylic Acid

1995 • 112 citations

Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins

1993 • 109 citations

Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.

1992 • 106 citations

Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol.

1992 • 105 citations

Endoplasmic reticulum calcium pump expression and control of cell growth.

1994 • 98 citations

Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes.

1991 • 89 citations

Inositol 1,4,5-trisphosphate-mediated quantal Ca2+ release measured by high resolution imaging of Ca2+ within organelles.

1993 • 86 citations

Kinetics of Thapsigargin- Ca2+-ATPase (Sarcoplasmic Reticulum) Interaction Reveals a Two-step Binding Mechanism and Picomolar Inhibition

1995 • 78 citations

Calcium pools, calcium entry, and cell growth

1996 • 76 citations

Mechanisms of inactivation of lipoxygenases by phenidone and BW755C

1991 • 64 citations

Structure‐Function Relationships in Sarcoplasmic or Endoplasmic Reticulum Type Ca²⁺ Pumps^a

1992 • 61 citations

Thapsigargin-resistant Intracellular Calcium Pumps

1995 • 61 citations

Angiotensin II Activates the Na+/HCO3- Symport through a Phosphoinositide-independent Mechanism in Cardiac Cells

1995 • 57 citations

Modulation of Ca2+ cycling in cardiac myocytes by arachidonic acid.

1993 • 56 citations

Store-operated Ca2+ Entry and Coupling to Ca2+ Pool Depletion in Thapsigargin-resistant Cells

1997 • 47 citations

Ca2+ Pools and Cell Growth: Arachidonic Acid Induces Recovery of Cells Growth-arrested by Ca2+ Pool Depletion

1996 • 46 citations

Metabolism of 5,6-epoxyeicosatrienoic acid by the human platelet. Formation of novel thromboxane analogs.

1991 • 44 citations

Purification and partial characterization of lipoxygenase with dual catalytic activities from human term placenta

1993 • 43 citations

Cytochrome P-450-dependent vasodilator responses to arachidonic acid in the isolated, perfused kidney of the rat.

1991 • 40 citations

Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes

1987 • 35 citations

Calcium mobilization by inositol phosphates and other intracellular messengers

1994 • 32 citations

Fe(III)-Lipoxygenase Converts Its Suicide-Type Inhibitor Octadeca-9,12-diynoic Acid into 11-Oxooctadeca-9,12-diynoic Acid

1995 • 15 citations

Evidence against a role of arachidonic acid metabolites in autoregulatory responses of the isolated perfused kidney of the rat

1991 • 10 citations

Some aspects of activation and inhibition of rat brain lipoxygenase

1992 • 10 citations

Prolactin secretion in anterior pituitary cells: effect of eicosanoids.

1992 • 10 citations