Regulation of Acetylcholine Synthesis in the Brain

Organization and morphological characteristics of cholonergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase

1983 • 745 citations

Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN¹

1973 • 585 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

The application of subcellular fractionation techniques to the study of brain function

1965 • 466 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

SODIUM‐DEPENDENT, HIGH AFFINITY CHOLINE UPTAKE

1978 • 420 citations

Choline uptake systems of rat brain synaptosomes

1973 • 387 citations

Brain Acetylcholine: Control by Dietary Choline

1976 • 386 citations

Biology of cholinergic function

1977 • 368 citations

High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis

1979 • 360 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

The Concept of a Blood-Brain Barrier

1980 • 347 citations

Brain acetylcholine: Increase after systematic choline administration

1975 • 338 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

The Interaction of Drugs and Subcellular Components in Animal Cells

1969 • 331 citations

Intracellular distributions of acetylcholine and choline acetylase

1958 • 288 citations

The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.

1980 • 288 citations

Comparative studies of substrates and inhibitors of choline transport and choline acetyltransferase.

1975 • 280 citations

VARIATION IN ACETYLCHOLINE CONTENT OF THE BRAIN WITH PHYSIOLOGICAL STATE

1949 • 271 citations

Utilization of sodium-dependent high affinity choline uptake as a measure of the activity of cholinergic neurons

1975 • 269 citations

Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces

1975 • 242 citations

Inhibition by hemicholinium-3 of (14C)acetylcholine synthesis and (3H)choline high-affinity uptake in rat striatal synaptosomes.

1973 • 232 citations

CARRIER MEDIATED BLOOD‐BRAIN BARRIER TRANSPORT OF CHOLINE AND CERTAIN CHOLINE ANALOGS

1978 • 223 citations

Identification and Properties of Methyltransferases That Synthesize Phosphatidylcholine in Rat Brain Synaptosomes

1980 • 212 citations

Brain Acetylcholine and Neuropsychiatric Disease

1979 • 209 citations

Choline acetyltransferase binding to and release from membranes

1968 • 203 citations

Concentration and origin of choline in the rat brain

1972 • 193 citations

HIGH AFFINITY CHOLINE UPTAKE: IONIC AND ENERGY REQUIREMENTS

1976 • 191 citations

Choline Acetyltransferase from Rat Brain

1968 • 188 citations

Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.

1983 • 181 citations

SYNAPTOSOMAL TRANSPORT: A CHLORIDE DEPENDENCE FOR CHOLINE, GABA, GLYCINE AND SEVERAL OTHER COMPOUNDS

1978 • 178 citations

Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals

1975 • 178 citations

The synthesis of acetylcholine in skeletal muscles of the rat

1982 • 166 citations

Concentrative Accumulation of Choline by Human Erythrocytes

1968 • 164 citations

Transport processes in the formation of the cerebrospinal fluid

1978 • 159 citations

PURIFICATION AND PROPERTIES OF CHOLINE ACETYLTRANSFERASE FROM OX BRAIN STRIATE NUCLEI

1971 • 158 citations

[¹⁴C]ACETYLCHOLINE SYNTHESIS BY CORTEX SLICES OF RAT BRAIN¹²

1968 • 158 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

SELECTIVE LOCALIZATION OF A HIGH AFFINITY CHOLINE UPTAKE SYSTEM AND ITS ROLE IN ACh FORMATTON IN CHOLINERGIC NERVE TERMINALS

1976 • 153 citations

SYNTHESIS AND RELEASE OF [¹⁴C]ACETYLCH0LINE IN SYNAPTOSOMES

1971 • 148 citations

Problems in the organization and control of acetylcholine synthesis in brain neurons

1984 • 142 citations

Utilization of Citrate, Acetylcarnitine, Acetate, Pyruvate and Glucose for the Synthesis of Acetylcholine in Rat Brain Slices

1981 • 140 citations

Proton gradient linkage to active uptake of [3H]acetylcholine by Torpedo electric organ synaptic vesicles

1982 • 135 citations

Choline and carnitine acetyltransferases of heart

1973 • 127 citations

A TEXTBOOK OF GENERAL PHYSIOLOGY

1965 • 125 citations

Newborn Rabbit Blood–Brain Barrier Is Selectively Permeable and Differs Substantially from the Adult

1980 • 124 citations

Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells.

1978 • 124 citations

PROVENANCE OF THE ACETYL GROUP OF ACETYLCHOLINE AND COMPARTMENTATION OF ACETYL‐CoA AND KREBS CYCLE INTERMEDIATES IN THE BRAIN IN VIVO

1974 • 122 citations

Regulation of Acetylcholine Synthesis: Does Cytoplasmic Acetylcholine Control High Affinity Choline Uptake?

1976 • 119 citations

Activation of high-affinity choline uptake in vitro by depolarizing agents.

1976 • 114 citations

KINETICS OF CHOLINE ACETYLTRANSFERASES (EC 2.3.1.6) FROM HUMAN AND OTHER MAMMALIAN CENTRAL AND PERIPHERAL NERVOUS TISSUES

1973 • 111 citations

Lecithin Consumption Increases Acetylcholine Concentrations in Rat Brain and Adrenal Gland

1978 • 107 citations

Regulation of acetylcholine synthesis in nervous tissue

1977 • 105 citations

Control of synthesis and release of radioactive acetylcholine in brain slices from the rat. Effects of neurotropic drugs

1973 • 103 citations

Evidence that an ATPase and a protonmotive force function in the transport of acetylcholine into storage vesicles.

1980 • 97 citations

Localization of Choline Acetyltransferase: Histochemistry at the Light Microscope Level

1970 • 94 citations

Choline Administration Elevates Brain Phosphorylcholine Concentrations

1982 • 89 citations

EFFECTS OF QUATERNARY BASES AND INORGANIC CATIONS ON ACETYLCHOLINE SYNTHESIS IN NERVOUS TISSUE

1967 • 88 citations

Multiple Forms of Choline‐O‐Acetyltransferase in Mouse and Rat Brain: Solubilization and Characterization

1983 • 87 citations

ACETYLCHOLINE SYNTHESIS FROM [2-¹⁴C]PYRUVATE IN RAT STRIATAL SLICES

1973 • 83 citations

Mechanisms controlling choline transport and acetylcholine synthesis in motor nerve terminals during electrical stimulation.

1979 • 83 citations

THE FORMATION OF CHOLINE AND OF ACETYLCHOLTNE BY BRAIN IN VITRO

1972 • 81 citations

Active transport of quaternary ammonium compounds by the choroid plexus in vitro

1965 • 80 citations

Trans-synaptic induction of adrenomedullary tyrosine hydroxylase activity by choline: evidence that choline administration can increase cholinergic transmission.

1977 • 77 citations

Increase in tissue concentration of acetylcholine in guinea pigs in vivo induced by administration of choline

1974 • 76 citations

Choline Administration: Modification of the Central Actions of Atropine

1978 • 73 citations

The effect of preganglionic nerve stimulation on the accumulation of certain analogues of choline by a sympathetic ganglion.

1977 • 71 citations

Acetylcholine Synthesis in Neurons

1979 • 70 citations

CHOLINE UPTAKE BY CHOLINERGIC NEURON CELL SOMAS

1976 • 66 citations

EVOLUTION DE LA DECHARGE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET VARIATIONS SIMULTANEES DE L'ACETYLCHOLINE AU COURS DE LA STIMULATION¹ CHANGES IN ACETYLCHOLINE LEVEL AND ELECTROPHYSIOLOGICAL RESPONSE DURING CONTINUOUS STIMULATION OF THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1974 • 65 citations

Acetyl‐CoA Synthesizing Enzymes in Cholinergic Nerve Terminals

1980 • 64 citations

Slow accumulation of choline acetyltransferase in crushed sciatic nerves of the rat

1973 • 63 citations

Transport of choline from plasma to cerebrospinal fluid in the rabbit with reference to the origin of choline and to acetylcholine metabolism in brain

1975 • 63 citations

RELATIONSHIP BETWEEN CHOLINE AVAILABILITY AND ACETYLCHOLINE SYNTHESIS IN DISCRETE REGIONS OF RAT BRAIN

1979 • 62 citations

Effects of oral choline administration on serum and CSF choline levels in patients with Huntington's Disease¹

1977 • 61 citations

Progress in Cholinergic Biology: Model Cholinergic Synapses

1983 • 61 citations

Neuropharmacological consequences of choline administration

1980 • 61 citations

The Effect of Acetylcholine Release on Choline Fluxes in Isolated Synaptic Terminals

1981 • 59 citations

Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain.

1982 • 59 citations

Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis

1980 • 59 citations

Exogenous Choline Enhances the Synthesis of Acetylcholine Only Under Conditions of Increased Cholinergic Neuronal Activity

1982 • 58 citations

ACETYLCHOLINE METABOLISM AND CHOLINE UPTAKE IN CORTICAL SLICES

1977 • 57 citations

Effects of choline and glucose on atropine-induced alterations of acetylcholine synthesis and content in the caudate nuclei of rats

1982 • 56 citations

ACCELERATION OF CHOLINE UPTAKE AFTER DEPOLARIZATION‐INDUCED ACETYLCHOLINE RELEASE IN RAT CORTICAL SYNAPTOSOMES

1978 • 55 citations

Effects of quaternary ammonium compounds on choline transport in red cells

1969 • 55 citations

Effect of Locally Applied Hemicholinium on the Acetylcholine Content of the Caudate Nucleus

1964 • 55 citations

SYNTHESIS OF ACETYLCHOLINE IN DIFFERENT COMPARTMENTS OF BRAIN NERVE TERMINALS IN VIVO AS STUDIED BY THE INCORPORATION OF CHOLINE FROM PLASMA AND THE EFFECT OF PENTOBARBITAL ON THIS PROCESS

1973 • 54 citations

Transport of choline acetyltransferase and acetylcholinesterase in the central stump and isolated segments of a peripheral nerve

1975 • 54 citations

The Utilization of Choline and Acetyl Coenzyme A for the Synthesis of Acetylcholine

1980 • 52 citations

Increase in hippocampal acetylcholine after choline administration

1977 • 52 citations

Precursors of acetyl groups in acetylcholine in the brain in vivo

1970 • 51 citations

Cerebrospinal Fluid Clearance of Choline and Some Other Amines

1972 • 51 citations

Choline administration and acetylcholine in brain

1979 • 51 citations

Equilibrium constants of the reactions of choline acetyltransferase, carnitine acetyltransferase, and acetylcholinesterase under physiological conditions.

1975 • 50 citations

OBSERVATIONS ON THE SUBCELLULAR DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE IN THE BRAIN TISSUE OF MAMMALS AND COMPARISONS OF ACETYLCHOLINE SYNTHESIS FROM ACETATE AND CITRATE IN HOMOGENATES AND NERVE‐ENDING FRACTIONS

1967 • 50 citations

Extracellular cations and the movement of choline across the erythrocyte membrane

1972 • 48 citations

CHANGES IN SYNAPTOSOMAL HIGH AFFINITY CHOLINE UPTAKE FOLLOWING ELECTRICAL STIMULATION OF GUINEA‐PIG CORTICAL SLICES: EFFECT OF ATROPINE AND PHYSOSTIGMINE

1981 • 48 citations

Multiple isoelectric and molecular weight variants of choline acetyltransferase. Artifact or real?

1984 • 47 citations

The use of choline acetyltransferase for measuring the synthesis of acetyl-coenzyme A and its release from brain mitochondria

1967 • 47 citations

Neural and non-neural acetylcholine in the rat diaphragm

1982 • 47 citations

Choline Uptake and Acetylcholine Synthesis in Synaptosomes: Investigations Using Two Different Labeled Variants of Choline

1981 • 47 citations

Steady-state concentrations of choline and acetylcholine in rat brain parts during a constant rate infusion of deuterated choline

1975 • 47 citations

CITRATE AS THE PRECURSOR OF THE ACETYL MOIETY OF ACETYLCHOLINE

1978 • 45 citations

The synthesis and release of acetylcholine in normal and denervated rat diaphragms during incubation in vitro

1983 • 44 citations

Choline transport is not coupled to acetylcholine synthesis

1979 • 44 citations

Free and bound acetylcholine in frog muscle.

1982 • 44 citations

EFFECT OF PRETREATMENT UNDER VARIOUS CATIONIC CONDITIONS ON ACETYLCHOLINE CONTENT AND CHOLINE TRANSPORT IN RAT WHOLE BRAIN SYNAPTOSOMES

1978 • 42 citations

The intra‐axonal transport of acetylcholine and cholinergic enzymes in rat sciatic nerve during regeneration after various types of axonal trauma

1979 • 42 citations

Cns effects of choline administration: Evidence for temporal dependence

1981 • 42 citations

A long‐lasting potentiation of transmitter release related to an increase in transmitter stores in a sympathetic ganglion

1977 • 42 citations

Effect of choline, phosphorylcholine and dimethylaminoethanol on brain acetylcholine level in the rat

1977 • 41 citations

Mobilization of cellular choline by stimulation of muscarine receptors in isolated chicken heart and rat cortex in vivo.

1983 • 41 citations

REGULATION OF ACETYLCHOLINE SYNTHESIS: CONTROL OF CHOLINE TRANSPORT AND ACETYLATION IN SYNAPTOSOMES

1978 • 41 citations

Acetylcoenzyme A and the synthesis of acetylcholine in neurones: review of recent progress.

1983 • 41 citations

The role of choline in the release of acetylcholine in isolated hearts

1978 • 40 citations

Bicarbonate and magnesium ion-ATP dependent stimulation of acetylcholine uptake by Torpedo electric organ synaptic vesicles

1980 • 38 citations

Origin of the Bicarbonate Stimulation of Torpedo Electric Organ Synaptic Vesicle ATPase

1982 • 38 citations

High-Affinity Transport of Choline in Neuronal Tissue

1980 • 37 citations

Effect of short-term starvation and choline on the acetylcholine content of organs of albino rats.

1972 • 36 citations

Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium.

1982 • 35 citations

Pharmacological augmentation of acetylcholine levels in kainate-lesioned rat striatum

1978 • 35 citations

Activation of muscarinic receptors stimulates the release of choline from brain slices

1984 • 35 citations

Relation between the content of acetyl-coenzyme A and acetylcholine in brain slices

1980 • 34 citations

Evidence for extramitochondrial pyruvate dehydrogenase involved in acetylcholine synthesis in nerve endings

1978 • 34 citations

Inhibition of the Synthesis of Acetylcholine in Rat Brain Slices by (−)‐Hydroxycitrate and Citrate

1981 • 34 citations

Factors affecting choline transport by the cat superior cervical ganglion during and following stimulation, and the relationship between choline uptake and acetylcholine synthesis

1981 • 34 citations

The incorporation of solubilized choline-transport activity into liposomes

1982 • 33 citations

High-Affinity Choline Transport in Proteoliposomes Derived from Rat Cortical Synaptosomes

1982 • 33 citations

Inhibition of [3H]acetylcholine active transport by tetraphenylborate and other anions.

1983 • 32 citations

Increased Acetylcholine Synthesis and Release Following Presynaptic Activity in a Sympathetic Ganglion

1983 • 31 citations

A MODEL OF HIGH AFFINITY CHOLINE TRANSPORT IN RAT CORTICAL SYNAPTOSOMES

1979 • 31 citations

Acetylcholine synthesis in rat neostriatal slices

1979 • 30 citations

The role of citrate derived from glucose in the acetylcholine synthesis in rat brain synaptosomes

1981 • 30 citations

Transport of choline out of the cranial cerebrospinal fluid spaces of the rabbit.

1980 • 29 citations

Ionic and Metabolic Requirements for High‐Affinity Choline Uptake and Acetylcholine Synthesis in Nerve Terminals at a Neuromuscular Junction

1980 • 28 citations

Increase in Exogenous Choline Fails to Elevate the Content or Turnover Rate of Cortical, Striatal, or Hippocampal Acetylcholine

1982 • 28 citations

Neuronal uptake of choline following release of acetylcholine in the perfused heart.

1980 • 28 citations

Choline acetyltransferase in the heart of adult rats

1982 • 28 citations

Release of acetylcholine in the isolated heart

1981 • 27 citations

Acetylcholine and oxidative metabolism in septum and hippocampus in vitro.

1983 • 27 citations

The Synthesis of Acetylcholine

1983 • 26 citations

Acetyl coenzyme A and acetylcholine in slices of rat caudate nuclei incubated in the presence of metabolic inhibitors.

1981 • 26 citations

Effect of Increasing Choline, In Vivo and In Vitro, on the Synthesis of Acetylcholine in a Sympathetic Ganglion

1981 • 26 citations

Solubilization of the choline transport system and re-incorporation into artificial membranes

1980 • 25 citations

Physical and Kinetic Properties of Choline Acetyl Transferase from Rat and Bovine Brain

1980 • 25 citations

Choline and PAH transport across blood-CSF barriers: The effect of lithium

1982 • 25 citations

Immunohistochemical localization of choline acetyltransferase using a monoclonal antibody: A radioautographic method

1983 • 25 citations

ACETYLTRIETHYLCHOLINE: A CHOLINERGIC FALSE TRANSMITTER IN CAT SUPERIOR CERVICAL GANGLION AND RAT CEREBRAL CORTEX

1977 • 25 citations

Origin of the acetyl moiety of acetylcholine in rat striatal synaptosomes : a specific pyruvate dehydrogenase involved in ACh synthesis?

1978 • 24 citations

The Neurochemical Basis of Acetylcholine Precursor Loading as a Therapeutic Strategy

1979 • 24 citations

HIGH AFFINITY CHOLINE TRANSPORT IN GUINEA PIG BRAIN AND THE EFFECT OF NOREPINEPHRINE

1975 • 23 citations

High‐Affinity Choline Uptake in the Hippocampus: Its Relationship to the Physiological State Produced by Administration of Barbiturates and Other Treatments

1982 • 23 citations

Acetylcholine Synthesis in Synaptosomes: Mode of Transfer of Mitochondrial Acetyl Coenzyme A

1981 • 23 citations

Presence, Metabolism, and Axonal Transport of Transmitters in Peripheral Mammalian Axons

1983 • 22 citations

Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices

1979 • 22 citations

Physostigmine facilitates choline efflux from isolated heart and cortex in vivo

1982 • 22 citations

The Effect of Preganglionic Stimulation on the Acetylcholine and Choline Content of a Sympathetic Ganglion

1971 • 21 citations

Acetylcoenzyme A and Acetylcholine in Slices of Rat Caudate Nuclei Incubated with (‐)‐Hydroxycitrate, Citrate, and EGTA

1982 • 21 citations

Effect of ethanol on brain CoA and acetyl ‐CoA¹

1976 • 20 citations

Uncoupling of acetylcholine uptake from the Torpedo cholinergic synaptic vesicle ATPase

1981 • 19 citations

Determination of Δψ, ΔpH and the proton electrochemical gradient in isolated cholinergic synaptic vesicles

1981 • 18 citations

The Independency of Choline Transport and Acetylcholine Synthesis

1982 • 17 citations

Serum and tissue factors that inhibit amine transport by the choroid plexus in vitro

1966 • 16 citations

β‐Hydroxybutyrate as a Precursor to the Acetyl Moiety of Acetylcholine

1981 • 16 citations

An endogeneous inhibitory factor for choline acetyltransferase

1983 • 16 citations

Effect of high plasma choline on brain area acetylcholine content : Drug intervention

1979 • 15 citations

The activation of presynaptic choline uptake by acetylcholine release.

1982 • 15 citations

Calcium-dependent release of acetyl-coenzyme A from liver mitochondria

1983 • 14 citations

Increase in striatal choline acetyltransferase activity after choline administration

1979 • 14 citations

Effects of Septal Lesions on Enzymes of Acetyl-CoA Metabolism in the Cholinergic System of the Rat Hippocampus

1982 • 12 citations

Activation of feline acetylcholine synthesis in the absence of release: dependence on sodium, calcium and the sodium pump.

1983 • 12 citations

Acetylcholine Release from Isolated Synaptic Vesicles Related to Ionic Permeability Changes: Continuous Detection with a Chemiluminescent Method

1982 • 11 citations

Progress in Modern Cholinergic Biology: Model Cholinergic Synapses

1983 • 10 citations

Evaluation of acetate uptake and its relative conversion to acetylcholine in Torpedo electric organ synaptosomes under different ionic and metabolic conditions

1984 • 10 citations

Ca2+ Ions and the Output of Acetylcoenzym e A from Brain Mitochondria

1983 • 8 citations

Studies on presynaptic cholinergic mechanisms using analogues of choline and acetate.

1982 • 8 citations

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