Immunoglobulin heavy and light chain gene sequences of a human CD5 positive immunocytoma and sequences of four novel VHIII germline genes

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Single-stranded DNA ‘blue’ T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering

1986 • 816 citations

[1] High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells

1987 • 329 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies.

1987 • 251 citations

Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences

1981 • 205 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

Structure and expression of the human immunoglobulin lambda genes.

1990 • 163 citations

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia.

1988 • 160 citations

Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias

1990 • 158 citations

Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomas.

1988 • 108 citations

The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

1991 • 91 citations

B cells of chronic lymphatic leukemia express V genes in unmutated form

1991 • 61 citations

Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.

1989 • 59 citations

Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies.

1989 • 58 citations

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma.

1989 • 48 citations

A rapid method for cloning and sequencing variable-region genes of expressed immunoglobulins

1987 • 38 citations

Purine degradative enzymes and immunological phenotypes in chronic B‐lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity

1986 • 9 citations

Immunophenotype analysis of B‐CLL lymphoma and immunocytoma

1989 • 7 citations