Innate Immune Defences in the Human Uterus during Pregnancy

Intrauterine Infection and Preterm Delivery

2000 • 2,501 citations

Preeclampsia: An excessive maternal inflammatory response to pregnancy

1999 • 1,855 citations

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

The role of cationic antimicrobial peptides in innate host defences

2000 • 1,184 citations

Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis

1998 • 821 citations

Mammalian defensins in immunity: more than just microbicidal

2002 • 682 citations

Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term

2003 • 670 citations

Cytokines, Prostaglandins and Parturition—A Review

2003 • 586 citations

Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

1996 • 571 citations

Role of Toll-Like Receptors in Pathogen Recognition

2003 • 545 citations

Role of membranes in the activities of antimicrobial cationic peptides

2002 • 534 citations

Discovery of five conserved β-defensin gene clusters using a computational search strategy

2002 • 480 citations

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

1986 • 477 citations

Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

1990 • 419 citations

MucoidPseudomonas aeruginosa, TNF- α , and IL-1 β , but Not IL-6, Induce Human β -Defensin-2 in Respiratory Epithelia

2000 • 409 citations

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

2000 • 400 citations

Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide

1997 • 390 citations

Antibacterial activity of antileukoprotease

1996 • 366 citations

Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

1993 • 348 citations

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.

1994 • 294 citations

Expression of the Peptide Antibiotic Human β-Defensin 1 in Cultured Gingival Epithelial Cells and Gingival Tissue

1998 • 278 citations

Antimicrobial Peptides as Mediators of Epithelial Host Defense

1999 • 277 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

SLPI and elafin: one glove, many fingers

2005 • 268 citations

Expression of β‐defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells

2002 • 251 citations

Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis

2004 • 240 citations

Expression and regulation of the pattern recognition receptors Toll‐like receptor‐2 and Toll‐like receptor‐4 in the human placenta

2002 • 238 citations

Antimicrobial factors in the cervical mucus plug

2002 • 228 citations

Expression of Natural Antimicrobials by Human Placenta and Fetal Membranes

2006 • 218 citations

Antimicrobial Polypeptides of Human Vernix Caseosa and Amniotic Fluid: Implications for Newborn Innate Defense

2003 • 195 citations

Elafin (elastase‐specific inhibitor) has anti‐microbial activity against Gram‐positive and Gram‐negative respiratory pathogens

1999 • 192 citations

Localization of human intestinal defensin 5 in Paneth cell granules

1997 • 188 citations

Surfactant protein A stimulates phagocytosis of specific pulmonary pathogens by alveolar macrophages

1996 • 187 citations

Proteomic biomarker analysis of amniotic fluid for identification of intra‐amniotic inflammation

2005 • 187 citations

Innate immune defences in the human endometrium.

2003 • 187 citations

Antimicrobial Polypeptides of Human Vernix Caseosa and Amniotic Fluid: Implications for Newborn Innate Defense

2003 • 180 citations

Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia

2001 • 179 citations

Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases.

1997 • 177 citations

Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes

2003 • 175 citations

The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core

1999 • 175 citations

Toll-like receptor 4: A potential link between “danger signals,” the innate immune system, and preeclampsia?

2005 • 169 citations

Innate Host Defense of Human Vaginal and CervicalMucosae

2006 • 140 citations

Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection

2002 • 136 citations

Presence of secretory leukocyte protease inhibitor in human endometrium and first trimester decidua suggests an antibacterial protective role

2000 • 130 citations

MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture

1999 • 126 citations

Antimicrobial activity of antiproteinases

2002 • 117 citations

Elafin is a potent inhibitor of proteinase 3

1991 • 115 citations

Detection of human defensin 5 in reproductive tissues

1997 • 114 citations

Host defense proteins in vernix caseosa and amniotic fluid

2004 • 112 citations

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)

2006 • 111 citations

Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium

2003 • 110 citations

The novel antimicrobial peptide β3-defensin is produced by the amnion: A possible role of the fetal membranes in innate immunity of the amniotic cavity

2004 • 102 citations

Human β-defensin-2: A natural antimicrobial peptide present in amniotic fluid participates in the host response to microbial invasion of the amniotic cavity

2007 • 93 citations

Purifkation and Characterization of Elastase-Specific Inhibitor. Sequence Homology with Mucus Proteinase Inhibitor

1991 • 91 citations

Elafin in Human Endometrium: An Antiprotease and Antimicrobial Molecule Expressed during Menstruation

2003 • 89 citations

Regulation of natural antibiotic expression by inflammatory mediators and mimics of infection in human endometrial epithelial cells

2002 • 84 citations

Lactoferrin in intrauterine infection, human parturition, and rupture of fetal membranes

2000 • 78 citations

Natural antimicrobial production by the amnion

2007 • 77 citations

Inflammatory Lung Secretions Inhibit Dendritic Cell Maturation and Function via Neutrophil Elastase

2006 • 76 citations

Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium

2003 • 73 citations

Differential regulation of secretory leukocyte protease inhibitor and elafin by progesterone

2003 • 73 citations

Detection of Human Defensins in the Placenta

1997 • 61 citations

Amniotic Fluid Lactoferrin in Intrauterine Infection

1999 • 59 citations

The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core

1999 • 51 citations

Genome-wide expression profiling of fetal membranes reveals a deficient expression of proteinase inhibitor 3 in premature rupture of membranes

2004 • 48 citations

The Antimicrobial/Elastase Inhibitor Elafin Regulates Lung Dendritic Cells and Adaptive Immunity

2006 • 45 citations

Lactoferrin in human amniotic fluid

1989 • 44 citations

Secretory leukocyte protease inhibitor concentration increases in amniotic fluid with the onset of labour in women: characterization of sites of release within the uterus

1999 • 43 citations

Production of secretory leukocyte protease inhibitor by human amniotic membranes and regulation of its concentration in amniotic fluid

2001 • 42 citations

Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastroinstestinal tracts

2006 • 39 citations

Surfactant protein-A mRNA expression by human fetal membranes is increased in histological chorioamnionitis but not in spontaneous labour at term

2007 • 34 citations

9 Hormonal and developmental regulation of pulmonary surfactant synthesis in fetal lung

1990 • 34 citations

Effect of lactoferrin on lipopolysaccharide (LPS) induced preterm delivery in mice

2000 • 29 citations

The relationship between trypsin activity in amniotic fluid and premature rupture of membranes

1986 • 24 citations

Labor induces a maternal inflammatory response syndrome

2004 • 22 citations

Polymorphonuclear Leukocytes in the Fetal Membranes are Activated in Patients with Preterm Delivery: Ultrastructural and Enzyme-histochemical Evidence

1999 • 22 citations

Neutrophil activation in preeclampsia. Are defensins and lactoferrin elevated in preeclamptic patients?

1997 • 21 citations

Elafin expression in human fetal and adult submandibular glands

2002 • 17 citations

Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?

2003 • 15 citations

Effect of lactoferrin on lipopolysaccharide (LPS) induced preterm delivery in mice

2000 • 9 citations