The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core

The PROSITE database, its status in 1997

1997 • 1,783 citations

Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues

1991 • 999 citations

A gene map of the human genome.

1996 • 986 citations

Transglutaminases

1984 • 589 citations

The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

1995 • 508 citations

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

1986 • 477 citations

Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

1990 • 419 citations

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

1997 • 370 citations

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.

1994 • 294 citations

The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.

1988 • 216 citations

SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking

1993 • 164 citations

The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.

1980 • 162 citations

Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia.

1996 • 142 citations

Elastase Inhibitor Elafin Is a New Type of Proteinase Inhibitor Which Has a Transglutaminase-Mediated Anchoring Sequence Termed “Cementoin”1

1994 • 116 citations

Antileukoprotease Inhibits Stratum Corneum Chymotryptic Enzyme

1996 • 110 citations

Skin-derived antileucoproteases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis

1990 • 103 citations

Crystal Structure of an Elastase-Specific Inhibitor Elafin Complexed with Porcine Pancreatic Elastase Determined at 1.9 Å Resolution

1996 • 102 citations

Purifkation and Characterization of Elastase-Specific Inhibitor. Sequence Homology with Mucus Proteinase Inhibitor

1991 • 91 citations

SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes

1994 • 91 citations

Immunohistochemical Localization of SKALP/Elafin in Psoriatic Epidermis

1993 • 88 citations

Lesional Elastase Activity in Psoriasis, Contact Dermatitis, and Atopic Dermatitis

1992 • 88 citations

Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases

1985 • 86 citations

Characterization and Gene Sequence of the Precursor of Elafin, an Elastase-specific Inhibitor in Bronchial Secretions

1993 • 82 citations

Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation.

1996 • 74 citations

Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures

1996 • 67 citations

Up-Regulation of Elafin/SKALP Gene Expression in Psoriatic Epidermis

1994 • 67 citations

Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment

1992 • 66 citations

Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level.

1995 • 63 citations

Isolation of Elafin and Elastase-Specific Inhibitor (ESI) from Bronchial Secretions. Evidence of Sequence Homology and Immunological Cross-Reactivity

1992 • 62 citations

Inhibitors of Acrosin and Granulocyte Proteinases from Human Genital Tract Secretions

1976 • 60 citations

Inhibition of Human Mast Cell Chymase by Secretory Leukocyte Proteinase Inhibitor: Enhancement of the Interaction by Heparin

1996 • 59 citations

Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties

1991 • 56 citations

Expression of SKALP/elafin during wound healing in human skin

1996 • 56 citations

Proteolysis in Cell Functions

1997 • 54 citations

Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin

1993 • 53 citations

Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.

1992 • 52 citations

Novel peptide inhibitor (SPAI) of Na+, K+-ATPase from porcine intestine

1989 • 52 citations

Solution structure of R-elafin, a specific inhibitor of elastase

1997 • 51 citations

Inhibition of Neutrophil Elastase Suppresses the Development of Skin Tumors in Hairless Mice

1996 • 48 citations

Identification and Sequence Analysis of Two New Members of the SKALP/elafin and SPAI-2 Gene Family

1997 • 47 citations

A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

1995 • 47 citations

Elastase Inhibitors for Treatment of Emphysema

1986 • 44 citations

Lesional elastase activity in psoriasis

1995 • 44 citations

The Interdependence of Lung Antioxidants and Antiprotease Defense in ARDS

1996 • 43 citations

Accelerated Evolution in Inhibitor Domains of Porcine Elafin Family Members

1996 • 42 citations

The Cloning of a Rapidly Evolving Seminal‐Vesicle‐Transcribed Gene Encoding the Major Clot‐Forming Protein of Mouse Semen

1996 • 42 citations

Levels of Skin-Derived Antileukoproteinase (SKALP)/Elafin in Serum Correlate with Disease Activity During Treatment of Severe Psoriasis with Cyclosporin A

1995 • 42 citations

Functions of the N-Terminal Domain of Secretory Leukoprotease Inhibitor

1994 • 40 citations

Synthesis and structure-activity relationships of elafin, an elastase-specific inhibitor

1992 • 34 citations

Review

1995 • 34 citations

Overexpression of the Gene for Polyubiquitin in Yeast Confers Increased Secretion of a Human Leucocyte Protease Inhibitor

1994 • 31 citations

Detection of antileukoprotease in connective tissue of the lung

1986 • 31 citations

Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart

1997 • 30 citations

Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12→q13

1994 • 29 citations

Evolution of the Trappin Multigene Family in the Suidae

1998 • 26 citations

The Gene of the Protease Inhibitor SKALP/Elafin Is a Member of the Rest Gene Family

1996 • 25 citations

Demonstration of Skin-Derived Antileukoproteinase (SKALP) in Urine of Psoriatic Patients

1992 • 25 citations

The N-terminal sequence of antileukoprotease isolated from bronchial secretion

1985 • 23 citations

Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter.

1997 • 20 citations

Exons Lost and Found

1996 • 19 citations

Skin-derived antileukoproteinase (SKALP) is decreased in pustular forms of psoriasis. A clue to the pathogenesis of pustule formation?

1996 • 18 citations

Crystallization of a Complex between an Elastase-specific Inhibitor Elafin and Porcine Pancreatic Elastase

1993 • 16 citations

Cloning, Characterization, and Tissue Distribution of Porcine SPAI, a Protein with a Transglutaminase Substrate Domain and the WAP Motif

1995 • 14 citations

Inhibition of Proteinase 3 Activity by Peptides Derived from Human Epidermis

1993 • 12 citations

Intratracheally-instilled antileukoprotease and α1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization

1994 • 11 citations

The effect of a peptide aldehyde reversible inhibitor of elastase on a human leucocyte elastase-induced model of emphysema in the hamster.

1987 • 9 citations

Elastase Inhibitors for Treatment of Emphysema Approaches to Synthesis and Biological Evaluation

1987 • 9 citations

Antiprotease Activity in Urine of Patients with Inflammatory Skin Disorders

1995 • 9 citations

Cryptic Origin of SPAI, a Plasma Protein with a Transglutaminase Substrate Domain and the WAP Motif, Revealed by in Situ Hybridization and Immunohistochemistry

1996 • 6 citations

In Vivo Adenovirus-Mediated Expression of Human Pre-Elafin, a Potent Neutrophil Elastase Inhibitor

1997 • 5 citations

Yeast artificial chromosome cloning and chromosomal localization of the abundant odontogenic keratocyst protein elafin

1996 • 4 citations