Estrogen Inhibits Systemic T Cell Expression of TNF-α and Recruitment of TNF-α+ T Cells and Macrophages into the CNS of Mice Developing Experimental Encephalomyelitis

Rate of Pregnancy-Related Relapse in Multiple Sclerosis

1998 • 1,463 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Antiinflammatory Effects of Estrogen on Microglial Activation¹

2000 • 360 citations

Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis

1989 • 346 citations

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

1998 • 344 citations

Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains

2001 • 336 citations

Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects.

1997 • 311 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Estriol ameliorates autoimmune demyelinating disease

1999 • 266 citations

Estrogen Treatment Down-Regulates TNF-α Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice

2001 • 259 citations

Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

2001 • 247 citations

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

1997 • 239 citations

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

2001 • 215 citations

Female sex steroids: effects upon microglial cell activation

2000 • 209 citations

Activity of multiple sclerosis during pregnancy and puerperium

1984 • 171 citations

Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

2000 • 164 citations

The Clinical Course of Multiple Sclerosis During Pregnancy and the Puerperium

1990 • 163 citations

Steroid sex hormones regulate the release of tumor necrosis factor by macrophages

1995 • 132 citations

Male SJL mice do not relapse after induction of EAE with PLP 139-151

1996 • 114 citations

Some Misconceptions about Understanding Autoimmunity through Experiments with Knockouts

1997 • 94 citations

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

1999 • 93 citations

β-Estradiol Suppresses T Cell-Mediated Delayed-Type Hypersensitivity through Suppression of Antigen-Presenting Cell Function and Th1 Induction

2000 • 80 citations

Mediation of the Immunomodulatory Effect of β-Estradiol on Inflammatory Responses by Inhibition of Recruitment and Activation of Inflammatory Cells and Their Gene Expression of TNF-α and IFN-γ

2000 • 77 citations

CD62L Is Required on Effector Cells for Local Interactions in the CNS to Cause Myelin Damage in Experimental Allergic Encephalomyelitis

2001 • 73 citations

Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by CNI-1493, a Macrophage-Deactivating Agent

1998 • 67 citations

Effect of pregnancy on collagen-induced arthritis in mice.

1987 • 66 citations

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.

1987 • 63 citations

Suppressive Effect of Pregnancy on the Development of Experimental Allergic Encephalomyelitis in Rabbits

1984 • 61 citations

Estrogen suppression of connective tissue deposition in a murine model of peritoneal adhesion formation.

1996 • 52 citations

Local Delivery of TNF by Retrovirus-Transduced T Lymphocytes Exacerbates Experimental Autoimmune Encephalomyelitis

1999 • 52 citations

Female Sex Hormones Modulate the Function of LPS‐treated Macrophages

2000 • 41 citations

Pregnancy and the susceptibility of Lewis rats to experimental allergic encephalomyelitis

1985 • 38 citations

Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice

1996 • 33 citations

Oestradiol suppression of delayed-type hypersensitivity in autoimmune (NZB/NZW)F1 mice is a trait inherited from the healthy NZW parental strain.

1989 • 31 citations

Immunological Diseases.

1988 • 30 citations

Analysis of the genetic encoding of oestradiol suppression of delayed-type hypersensitivity in (NZB x NZW) F1 mice.

1991 • 27 citations

Collagen‐Induced Arthritis and Pregnancy in Mice: The Effects of Pregnancy on Collagen‐Induced Arthritis and the High Incidence of Infertility in Arthritic Female Mice

1986 • 26 citations

Suppression of Delayed-Type Hypersensitivity in Mice Pretreated With Diethylstilbesterol: Involvement of Sex Hormones in Immunomodulation

1988 • 20 citations