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Medicinal chemistry of target family-directed masterkeys

Data up to Jan 2025

Published2003
Citations208
References40

Total Citations Per Year

Abstract

References (40)

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

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1998 • 45 citations

Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-trans-lactam Template

2000 • 44 citations

Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

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1998 • 41 citations

Tifluadom, a κ-opiate agonist, acts as a peripheral cholecystokinin receptor antagonist

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Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease

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Thrombin inhibitors based on [5,5] trans-fused indane lactams

1999 • 21 citations

5,5-Trans lactone-containing inhibitors of serine proteases: Identification of a novel, acylating thrombin inhibitor

1998 • 17 citations

As biotech turns 20...

2002 • 17 citations

Pyrrolidine-5,5-trans-lactams. 2. The Use of X-ray Crystal Structure Data in the Optimization of P3 and P4 Substituents

2002 • 13 citations

Too many targets, not enough target validation

2001 • 13 citations

MAJOR DRUG FIRMS EKE OUT INCREASES

2003 • 1 citations

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Medicinal chemistry of target family-directed masterkeys (2003) – Drug Discovery Today | Metascience Observatory Explorer