Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

Method for Determination of the Amino Acid Sequence in Peptides.

1950 • 1,360 citations

Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

1983 • 631 citations

Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

1986 • 322 citations

An opioid benzodiazepine

1982 • 201 citations

Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurones

1984 • 190 citations

The Schild regression in the process of receptor classification

1982 • 168 citations

Quinazolines and 1,4-Benzodiazepines. VI.^1a Halo-, Methyl-, and Methoxy-substituted 1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones^1b,c

1962 • 145 citations

In vivo pharmacology of L-364,718, a new potent nonpeptide peripheral cholecystokinin antagonist.

1987 • 137 citations

Classification and function of CCK receptors

1987 • 121 citations

A Rearrangement of 5-Aryl-1,3-dihydro-2H-1,4-benzodiazepine-2-one 4-Oxides¹

1962 • 112 citations

Solid‐Phase Methods in Protein Sequence Analysis

1980 • 110 citations

Effects of L-364,718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas

1988 • 94 citations

Synthesis of cholecystokinin-pancreozymin. I. C-terminal dodecapeptide

1970 • 89 citations

Silafunctional compounds in organic synthesis. 33. Metalated allylaminosilane: a new, practical reagent for the stereoselective .alpha.-hydroxyallylation of aldehydes to erythro-1,2-diol skeletons

1987 • 82 citations

Species differences in the localization of ‘peripheral’ type cholecystokinin receptors in rodent brain

1987 • 73 citations

Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists

1987 • 73 citations

Synthesis and resolution of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones

1987 • 69 citations

Reversal of Antinociceptive Effect of Cholecystokinin by Benzodiazepines and a Benzodiazepine Antagonist, Ro 15-1788

1985 • 48 citations

Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea-pig gallbladder

1985 • 47 citations

Mapping the dopamine receptor. 1. Features derived from modifications in ring E of the neuroleptic butaclamol

1979 • 44 citations

Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364,718, a specific cholecystokinin receptor antagonist.

1987 • 42 citations

On the biologically active structures of cholecystokinin, little gastrin, and enkephalin in the gastrointestinal system.

1987 • 37 citations

Cholecystokinin receptor antagonists: a review.

1987 • 32 citations

A new amine resolution method and its application to 3-aminobenzodiazepines

1987 • 27 citations

Benzolactams. A new class of converting enzyme inhibitors

1983 • 24 citations

(+)- and (-)-3-Methoxycyproheptadine. A comparative evaluation of the antiserotonin, antihistaminic, anticholinergic, and orexigenic properties with cyproheptadine

1977 • 22 citations

Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives

1983 • 22 citations

The cholecystokinin antagonist L-364,718 inhibits the action of cholecystokinin but not bombesin on rat pancreatic secretion in vivo

1988 • 20 citations

An expedient synthesis of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one

1987 • 17 citations