Inhibition of Human Immunodeficiency Virus Type-1 env Expression by C-5 Propyne Oligonucleotides Specific for Rev-Response Element Stem-Loop V

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

1993 • 2,034 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Cationic liposome-mediated transfection

1989 • 974 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

1992 • 609 citations

Current concepts in antisense drug design

1993 • 566 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

1988 • 397 citations

HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA

1991 • 376 citations

Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes.

1992 • 334 citations

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

1986 • 303 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

Intracellular disposition and metabolism of fluorescently-labled unmodified and modified oligouncleotides microijjected into mammalian cells

1993 • 239 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

Relation of Phenotype Evolution of HIV-1 to Envelope V2 Configuration

1993 • 236 citations

Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology.

1992 • 231 citations

Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.

1991 • 226 citations

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

1992 • 223 citations

Oligonucleotide analogues as potential chemotherapeutic agents.

1988 • 221 citations

Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.

1985 • 204 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.

1992 • 159 citations

Functional Analysis of CAR, the Target Sequence for the Rev Protein of HIV-1

1989 • 152 citations

Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment.

1992 • 125 citations

Quantitative hybridization-arrant of mRNA InXenopusoocytes using single-tiranded coanplementary DNA or ollgonudeotlde probes

1985 • 111 citations

100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.

1989 • 110 citations

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure

1990 • 102 citations

Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET)

1994 • 100 citations

Oligonucleotides encapsulated in pH sensitive liposomes are efficient toward Friend retrovirus

1992 • 84 citations

Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine

1990 • 67 citations

Extensive sequence-specific information throughout the CAR/RRE, the target sequence of the human immunodeficiency virus type 1 Rev protein

1992 • 65 citations

A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1

1992 • 56 citations

In vitroeffect of antisense oligonucleotides on human immunodeficiency virus type 1 reverse transcription

1992 • 46 citations

Non–Sequence-Specific Inhibition of Transferrin Receptor Expression in HL-60 Leukemia Cells by Phosphorothioate Oligodeoxynucleotides

1991 • 43 citations

Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element

1993 • 41 citations

Human immunodeficiency virus type 1 Tat does not transactivate mature trans-acting responsive region RNA species in the nucleus or cytoplasm of primate cells

1991 • 19 citations

Inhibition of human immunodeficiency virus type 1 Rev-Rev-response element complex formation by complementary oligonucleotides

1992 • 17 citations