A G _sα mutant designed to inhibit receptor signaling through G _s

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Rapid GDP release from Gsα in patients with gain and loss of endocrine function

1994 • 288 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.

1986 • 261 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

1991 • 224 citations

Pheromone signalling and polarized morphogenesis in yeast

1997 • 221 citations

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

1992 • 205 citations

G-protein diseases furnish a model for the turn-on switch

1998 • 192 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq

1993 • 161 citations

RGS4 Inhibits Gq-mediated Activation of Mitogen-activated Protein Kinase and Phosphoinositide Synthesis

1997 • 157 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go).

1986 • 150 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

Stoichiometry of receptor‐G _s ‐adenylate cyclase interactions

1991 • 139 citations

The active role of βγ in signal transduction

1994 • 126 citations

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

1991 • 110 citations

Reciprocal regulation of G _sα by palmitate and the βγ subunit

1996 • 99 citations

Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.

1995 • 93 citations

The A326S Mutant of Giα1 as an Approximation of the Receptor-bound State

1998 • 87 citations

Studies of RAS Function in the Yeast Saccharomyces cerevisiae

1988 • 76 citations

Conditional activation defect of a human G _sα mutant

1997 • 59 citations

Functional Analysis of a Dominant Negative Mutant of Gαi2

1995 • 54 citations

Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding.

1993 • 50 citations

Current opinion in cell biology

1990 • 49 citations

A dominant negative G alpha s mutant is rescued by secondary mutation of the alpha chain amino terminus.

1991 • 48 citations

The Guanine-Nucleotide-Binding Protein Subunit Galphai2 is Involved in Calcium Activation of Phospholipase A2. Effects of the Dominant Negative Galphai2 Mutant, [G203T]Galphai2, on Activation of Phospholipase A2 in Chinese Hamster Ovary Cells

1995 • 30 citations

Second Site Suppressor Mutations of a GTPase-deficient G-Protein α-Subunit

1998 • 30 citations

A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors.

1991 • 23 citations

The Guanine-Nucleotide-Binding Protein Subunit Galphai2 is Involved in Calcium Activation of Phospholipase A2. Effects of the Dominant Negative Galphai2 Mutant, [G203T]Galphai2, on Activation of Phospholipase A2 in Chinese Hamster Ovary Cells

1995 • 19 citations

A Mutation in the Putative Mg²⁺-Binding Site of G_s α Prevents Its Activation by Receptors

1991 • 6 citations