Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Processing of gene expression data generated by quantitative real-time RT-PCR.

2002 • 1,402 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 541 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 448 citations

LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

1991 • 318 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

Signalling sphingomyelinases: which, where, how and why?11With the participation of Nathalie Andrieu-Abadie, Nathalie Augé, Bruno Ségui, Emmanuelle Uro-Coste, Robert Salvayre, INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910 Toulouse Cedex 4, France, and Christine Bezombes, Véronique Mansat-De Mas, INSERM CJF 9503, Institut Claudius Régaud, Toulouse, France.

1999 • 305 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Cloning and characterization of the mammalian brain-specific, Mg ²⁺ -dependent neutral sphingomyelinase

2000 • 296 citations

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A

1999 • 292 citations

C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p

2001 • 277 citations

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

2001 • 267 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

1995 • 247 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway

1995 • 219 citations

An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.

1995 • 215 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility

1999 • 209 citations

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

1996 • 206 citations

Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line

2002 • 197 citations

Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

1994 • 196 citations

Biochemical Properties of Mammalian Neutral Sphingomyelinase2 and Its Role in Sphingolipid Metabolism

2003 • 182 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation

2002 • 167 citations

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

1995 • 165 citations

Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria

2001 • 162 citations

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae

1993 • 149 citations

Mass Spectrometric Identification of Increased C16 Ceramide Levels During Apoptosis

1999 • 148 citations

A widely expressed transcription factor with multiple DNA sequence specificity,CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

1998 • 142 citations

Localization of Furin to the trans-Golgi Network and Recycling from the Cell Surface Involves Ser and Tyr Residues within the Cytoplasmic Domain

1995 • 131 citations

Role for de Novo Sphingoid Base Biosynthesis in the Heat-induced Transient Cell Cycle Arrest of Saccharomyces cerevisiae

2001 • 128 citations

Sphingomyelinases in cell regulation

1997 • 127 citations

The cadherin superfamily

2001 • 122 citations

BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome

2003 • 111 citations

Ceramide generation by two distinct pathways in tumor necrosis factor α‐induced cell death

2001 • 105 citations

Function of the Cloned Putative Neutral Sphingomyelinase as Lyso-platelet Activating Factor-Phospholipase C

1999 • 102 citations

Phosphatidic Acid Is a Potent And Selective Inhibitor of Protein Phosphatase 1 and an Inhibitor of Ceramide-mediated Responses

1999 • 100 citations

Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line

2001 • 96 citations

The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal

2000 • 93 citations

Regulation of Cyclin-Dependent Kinase 2 Activity by Ceramide

2000 • 90 citations

ETS1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin

2000 • 88 citations

Endothelial nitric oxide synthase activity is linked to its presence at cell‒cell contacts

2002 • 82 citations

Neutral sphingomyelinase: past, present and future

1999 • 80 citations

Analysis of E-Cadherin in Diffuse-Type Gastric Cancer Using a Mutation-Specific Monoclonal Antibody

1999 • 74 citations

Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells

1997 • 72 citations

Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M

1998 • 66 citations

Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid

2003 • 66 citations

Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22

1997 • 63 citations

Subcellular Localization of β-Catenin Is Regulated by Cell Density

2002 • 61 citations

Endothelial nitric oxide synthase activity is linked to its presence at cell–cell contacts

2002 • 58 citations

Expression of E-cadherin by human retinal pigment epithelium: delayed expression in vitro.

1999 • 57 citations

Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis

1998 • 53 citations

Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology.

2002 • 52 citations

The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering

1998 • 49 citations

Sphingomyelin-degrading pathways in human cells

1999 • 37 citations

Induction of p21 during ceramide-mediated apoptosis in human hepatocarcinoma cells

1998 • 30 citations

Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells

2002 • 27 citations

Maintenance of the Epithelial Barrier in a Bronchial Epithelial Cell Line is Dependent on Functional E-cadherin Local to the Tight Junctions

2002 • 22 citations

cca1 Is Required for Formation of Growth-arrested Confluent Monolayer of Rat 3Y1 Cells

1997 • 21 citations

Biochemical and morphological identification of ceramide-induced cell cycle arrest and apoptosis in cultured granulosa cells

1999 • 16 citations

Mapping the chromosome 16 cadherin gene cluster to a minimal deleted region in ductal breast cancer

2001 • 16 citations

Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation

2001 • 9 citations