The Inherited Basis of Human Radiosensitivity

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

Localization of an ataxia-telangiectasia gene to chromosome 11q22–23

1988 • 677 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

Leukemia and lymphoma in ataxia telangiectasia

1996 • 619 citations

Multiple Primary Cancers in Families With Li-Fraumeni Syndrome

1998 • 548 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

1998 • 503 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA

1996 • 411 citations

Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

2000 • 387 citations

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

1999 • 386 citations

The Fanconi anaemia group G gene FANCG is identical with XRCC9

1998 • 347 citations

Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens

1976 • 340 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

2000 • 327 citations

Mortality and Cancer Incidence in 263 Patients With Ataxia-Telangiectasia<xref ref-type="fn" rid="FN1">2</xref>

1986 • 309 citations

Cancer Risks in A-T Heterozygotes

1994 • 287 citations

The christie hospital breast conservation trial: An update at 8 years from inception

1993 • 285 citations

Cancer Risk in ATM Heterozygotes: A Model of Phenotypic and Mechanistic Differences between Missense and Truncating Mutations

1999 • 285 citations

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1996 • 282 citations

The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

2000 • 277 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Nijmegen breakage syndrome

2000 • 265 citations

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

1996 • 261 citations

Ataxia Telangiectasia

1967 • 259 citations

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

1997 • 253 citations

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

1999 • 234 citations

Isolation of a cDNA Representing the Fanconi Anemia Complementation Group E Gene

2000 • 229 citations

Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae.

1993 • 218 citations

High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasia

1980 • 173 citations

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

1995 • 167 citations

Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy

1996 • 162 citations

In vitro chromosomal radiosensitivity in “chromosomal breakage syndromes”

1973 • 149 citations

Alteration of N-Terminal Phosphoesterase Signature Motifs Inactivates Saccharomyces cerevisiae Mre11

1998 • 140 citations

Functional Activity of the Fanconi Anemia Protein FAA Requires FAC Binding and Nuclear Localization

1998 • 138 citations

Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer

1995 • 137 citations

Complementation Analysis in Fanconi Anemia: Assignment of the Reference FA-H Patient to Group A

2000 • 136 citations

A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF

1999 • 136 citations

The cytogenetics of ataxia telangiectasia

1991 • 125 citations

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage

1999 • 115 citations

V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder.

1993 • 115 citations

A Comparison of the Radiosensitivity of Lymphocytes from Normal Donors, Cancer Patients, Individuals with Ataxia-telangiectasia (A-T) and A-T Heterozygotes

1995 • 110 citations

The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21.

1997 • 107 citations

Autozygosity Mapping of a Seckel Syndrome Locus to Chromosome 3q22.1-q24

2000 • 104 citations

Fanconi Anemia

2000 • 104 citations

Current perspectives on radiation-induced breast cancer.

1998 • 102 citations

Protective roles for ATM in cellular response to oxidative stress

2000 • 97 citations

Radiosensitivity of ataxia-telangiectasia, X-linked agammaglobulinemia, and related syndromes using a modified colony survival assay.

1994 • 95 citations

The Importance of Genetics for the Optimization of Radiation Therapy A Hypothesis

1988 • 90 citations

Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy

1997 • 86 citations

Loss of atm radiosensitizes multiple p53 null tissues.

1998 • 84 citations

Lack of Correlation of Human Fibroblast Radiosensitivityin Vitrowith Early Skin Reactions in Patients Undergoing Radiotherapy

1993 • 82 citations

Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.

1995 • 80 citations

A test for Fanconi's anemia

1987 • 75 citations

AT‐related disorder

1988 • 71 citations

SNX5, a New Member of the Sorting Nexin Family, Binds to the Fanconi Anemia Complementation Group A Protein

1999 • 70 citations

Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.

1993 • 68 citations

Normal tissue radiosensitivity in breast cancer patients

1995 • 67 citations

Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients

1998 • 65 citations

Fine Localization of the Nijmegen Breakage Syndrome Gene to 8q21: Evidence for a Common Founder Haplotype

1998 • 53 citations

Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia–telangiectasia

1998 • 48 citations

In-vitro chromosomal radiosensitivity in Fanconi's anemia

1971 • 47 citations

Characterization of regions functional in the nuclear localization of the Fanconi anemia group A protein

1999 • 44 citations

Complementation analysis of ataxia-telangiectasia.

1985 • 32 citations

Cellular responses to radiation and risk of breast cancer

1999 • 24 citations

Increased bleomycin-induced chromosome damage in lymphocytes of patients with common variable immunodeficiency indicates an involvement of chromosomal instability in their cancer predisposition

1989 • 22 citations

Common variable immunodeficiency and malignancy: a report of two cases and possible explanation for the association

1990 • 18 citations

Radiobiology of Ataxia-Telangiectasia

1993 • 14 citations

Loss of the Fanconi anemia group C protein activity results in an inability to activate caspase-3 after ionizing radiation

2000 • 14 citations

Deleted Work

1955 • 0 citations