Human epidermal cells progressively lose their cardiolipins during ageing without change in mitochondrial transmembrane potential

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture

1983 • 1,088 citations

Mitochondrial role in cell aging

1980 • 919 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING

1990 • 490 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME

1984 • 442 citations

Practical flow cytometry

1989 • 374 citations

10N‐Nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria

1992 • 320 citations

Culture of Animal Cells. A manual for basic techniques

2000 • 319 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes.

1984 • 300 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

Influence of Mitochondrial Radical Formation on Energy‐Linked Respiration

1978 • 168 citations

10-N Nonyl-Acridine Orange: A fluorescent probe which stains mitochondria independently of their energetic state

1989 • 156 citations

Age Changes in Size and Number of Mitochondria of Human Hepatic Cells

1968 • 139 citations

Mitochondrial production of pro-oxidants and cellular senescence

1992 • 137 citations

Regulation of mitochondrial respiration in senescence

1972 • 135 citations

An update on the mitochondrial-DNA mutation hypothesis of cell aging

1992 • 135 citations

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention

1992 • 128 citations

Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

1981 • 117 citations

The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina

1985 • 115 citations

Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria

1990 • 112 citations

Direct analysis and significance of cardiolipin transverse distribution in mitochondrial inner membranes

1994 • 103 citations

Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

1992 • 102 citations

Calcium induction of transglutaminase and the formation of ɛ(γ-glutamyl)lysine cross-links in cultured mouse epidermal cells

1981 • 96 citations

Prospects for the genetics of human longevity

1993 • 89 citations

Automatic morphometric analysis of skeletal muscle fibers in the aging man

1987 • 72 citations

In situ flow cytometric analysis of nonyl acridine orange‐stained mitochondria from splenocytes

1988 • 70 citations

Effect of age on the function of mitochondria isolated from brain and heart tissue

1980 • 69 citations

Aging and Photoaging Affect Gene Expression in Cultured Human Keratinocytes

1994 • 68 citations

Aging-dependent modification of lipid composition and lipid structural order parameter of hepatic mitochondria

1982 • 67 citations

Use of nonyl acridine orange and rhodamine 123 to follow biosynthesis and functional assembly of mitochondrial membrane during L1210 cell cycle

1990 • 60 citations

Lipid changes with aging in cardiac mitochondrial membranes

1984 • 59 citations

Specific interaction of the new fluorescent dye 10‐N‐nonyl acridine orange with inner mitochondrial membrane

1990 • 58 citations

Mitochondrial function and superoxide generation from submitochondrial particles of aged rat hearts

1990 • 57 citations

A fluorescence-microscopic and flow-cytometric study of HeLa cells with an experimentally induced respiratory deficiency

1992 • 47 citations

Effect of senescence on Ca2+—ion transport by heart mitochondria

1982 • 42 citations

Evidence for increased degeneration of mitochondria in old rats. A brief note

1978 • 41 citations

Lack of age-dependent changes in rat heart mitochondria

1987 • 39 citations

A new method for testing cell ageing using two mitochondria specific fluorescent probes

1990 • 37 citations

Mitochondrial DNA in sickness and in health.

1990 • 34 citations

Monitoring of the mitochondrial and plasma membrane potentials in human fibroblasts by tetraphenylphosphonium ion distribution

1987 • 29 citations

Effect of aging on the oxidative phosphorylation pathway

1990 • 28 citations

Decreased activity of the phosphate carrier and modification of lipids in cardiac mitochondria from senescent rats

1992 • 28 citations

Decreased membrane potential of T lymphocytes in ageing mice: flow cytometric studies with a carbocyanine dye.

1985 • 26 citations

Intracellular Calcium and Cell Function

1989 • 24 citations

Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing

1992 • 22 citations

Flow-cytometric analysis of mitochondria-associated fluorescence in young and old human fibroblasts

1986 • 21 citations

The Relationship of in Vitro Studies to in Vivo Human Aging

1981 • 21 citations

Age-Dependent Changes in the Structure-Function Correlation of ADP/ATP-Translocating Mitochondrial Membranes

1982 • 20 citations

Does mitochondrial ATP synthesis decline as a function of change in the membrane environment with ageing

1983 • 17 citations

Some biochemical properties of human lymphoblastoid Namalwa cells grown anaerobically.

1991 • 16 citations

Cardiolipin synthesis during the cell cycle of the yeastSaccharomyces cerevisiae

1977 • 10 citations

Age-related changes in respiration coupled to phosphorylation. I. Hepatic mitochondria

1988 • 10 citations

A new methodology for testing chemicals and drugs on cell activity

1990 • 4 citations

Deleted Work

1955 • 0 citations