Levels of Fetal Hemoglobin Necessary for Treatment of Sickle Cell Disease

Sickle-cell disease

1997 • 765 citations

Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

1984 • 514 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.

1982 • 396 citations

DNA sequence variation associated with elevated fetal G gamma globin production

1985 • 384 citations

Is there a threshold level of fetal hemoglobin that ameliorates morbidity in sickle cell anemia?

1984 • 298 citations

Natural History of Sickle Cell Anemia in Saudi Arabs

1978 • 287 citations

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

1983 • 270 citations

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

1983 • 248 citations

Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients.

1985 • 238 citations

The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease

1981 • 216 citations

Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia

1987 • 202 citations

SICKLE CELL DISEASE IN ORISSA STATE, INDIA

1986 • 191 citations

Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes

1985 • 182 citations

Participation of hemoglobins A and F in polymerization of sickle hemoglobin.

1977 • 170 citations

Studies on Abnormal Hemoglobins

1953 • 166 citations

Effects of thalassemia and microcytosis on the hematologic and vasoocclusive severity of sickle cell anemia

1984 • 163 citations

Stimulation of F-Cell Production in Patients with Sickle-Cell Anemia Treated with Cytarabine or Hydroxyurea

1985 • 160 citations

Rate of Sickling of Red Cells during Deoxygenation of Blood from Persons with Various Sickling Disorders

1964 • 155 citations

Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in Baboons

1987 • 150 citations

Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins

1979 • 141 citations

Requirements for therapeutic inhibition of sickle haemoglobin gelation

1978 • 138 citations

Molecular Analysis of the High-Hemoglobin-F Phenotype in Saudi Arabian Sickle Cell Anemia

1987 • 118 citations

Lack of influence of fetal hemoglobin levels or erythrocyte indices on the severity of sickle cell anemia.

1980 • 105 citations

Sickle Hemoglobin Polymerization in Solution and in Cells

1985 • 104 citations

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

1983 • 93 citations

Role of hybrid tetramer formation in gelation of haemoglobin S

1975 • 76 citations

Sickle cell anemia and trait in Southern India: Further studies

1979 • 71 citations

5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens

1985 • 62 citations

Hb F Synthesis in Sickle Cell Anaemia: a Comparison of Saudi Arab Cases with those of African Origin

1980 • 62 citations

Alpha thalassemia and the hematology of homozygous sickle cell disease in childhood

1986 • 52 citations

Production of F cells in sickle cell anemia: regulation by a genetic locus or loci separate from the beta-globin gene cluster

1984 • 46 citations

Sickle cell anemia as a syndrome: A review of diagnostic features

1979 • 37 citations

The ^Gγ‐δβ‐thalassemia and ^Gγ‐β°‐HPFH conditions in combination with β‐thalassemia and Hb S

1977 • 33 citations

Clinical, hematologic and biosynthetic studies in sickle cell‐β°‐thalassemia: A comparison with sickle cell anemia

1976 • 30 citations

Sickle beta 0 thalassemia in Eastern Saudi Arabia.

1980 • 30 citations