The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51)

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

1988 • 302 citations

Mode of Action and Resistance to Azole Antifungals Associated with the Formation of 14α-Methylergosta-8,24(28)-dien-3β,6α-diol

1995 • 286 citations

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

1982 • 285 citations

Mechanistic studies on aromatase and related CC bond cleaving P-450 enzymes

1993 • 193 citations

Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5′-CAG-3′ (leucine) anticodon.

1993 • 146 citations

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

1991 • 120 citations

Mechanism of the Acyl-Carbon Cleavage and Related Reactions Catalyzed by Multifunctional P-450s: Studies on Cytochrome P-45017.alpha.

1994 • 117 citations

Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.

1991 • 116 citations

Nucleotide sequence of cytochrome P450 LIAI (lanosterol 14α-demethylase) fromCandida albicans

1989 • 106 citations

Molecular genetic analysis of azole antifungal mode of action

1993 • 100 citations

A unified mechanistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzymes

1991 • 90 citations

Microsomal enzymes of cholesterol biosynthesis. Purification of lanosterol 14 alpha-methyl demethylase cytochrome P-450 from hepatic microsomes.

1986 • 86 citations

Chemical and enzymic studies on the characterization of intermediates during the removal of the 14α-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives

1978 • 80 citations

The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis

1969 • 77 citations

Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation.

1987 • 74 citations

Mechanism of human placental aromatase: A new active site model

1993 • 67 citations

Purification and reconstitution properties of human placental aromatase. A cytochrome P-450-type monooxygenase

1986 • 65 citations

Mechanistic consideration of P-450 dependent enzymic reactions: studies on oestriol biosynthesis

1988 • 65 citations

Androgen Formation by Cytochrome P450 CYP17. Solvent Isotope Effect and pL Studies Suggest a Role for Protons in the Regulation of Oxene versus Peroxide Chemistry

1994 • 62 citations

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-45017.alpha.; 17.alpha.-hydroxylase-17,20-lyase)

1995 • 58 citations

[14] Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

1991 • 54 citations

Incorporation of label from¹⁸O₂into acetate during side-chain cleavage catalysed by cytochrome P-450_17α(17α-hydroxylase-17,20-lyase)

1994 • 42 citations

Purification and properties of cytochrome P-450-dependent 14 α-sterol demethylase from Candida albicans

1989 • 37 citations

Generation of the soluble and functional cytosolic domain of microsomal cytochrome P450 52A3.

1994 • 34 citations

Purification and characterization of cytochrome P-45014DM (lanosterol 14α-demethylase) from pig liver microsomes

1991 • 20 citations

Benzyl esters in the gas-chromatographic purification of radioactive acetic acid from bacteria, and for the possible analysis of other short-chain acids

1973 • 16 citations

The synthesis of some 32-functionalised lanostane derivatives

1972 • 11 citations

Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation.

1993 • 10 citations

On the oxidation of hydrazones by lead tetra-acetate

1970 • 9 citations

Purification of a human cytochrome P-450 Isozyme catalyzing lanosterol 14α-demethylation

1993 • 9 citations

A transition from ionic to free-radical mechanisms in chemistry and enzymology

1994 • 7 citations