Early nutrition and epigenetic programming: chasing shadows

Chromatin Modifications and Their Function

2007 • 10,144 citations

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

Human DNA methylomes at base resolution show widespread epigenomic differences

2009 • 4,388 citations

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

2007 • 3,994 citations

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

2009 • 3,349 citations

Genome-scale DNA methylation maps of pluripotent and differentiated cells

2008 • 2,432 citations

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

2006 • 2,241 citations

Linking DNA methylation and histone modification: patterns and paradigms

2009 • 2,133 citations

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

2007 • 2,094 citations

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

2009 • 2,094 citations

Dissecting direct reprogramming through integrative genomic analysis

2008 • 1,461 citations

Chromatin signatures of pluripotent cell lines

2006 • 1,288 citations

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

2009 • 1,146 citations

Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring

2005 • 1,128 citations

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

2009 • 1,110 citations

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

2009 • 1,056 citations

Non‐coding RNAs: regulators of disease

2009 • 1,027 citations

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

2008 • 1,026 citations

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

2008 • 965 citations

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

2000 • 943 citations

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

2008 • 864 citations

CpG islands – ‘A rough guide’

2009 • 831 citations

Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension

2000 • 810 citations

DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status

2007 • 767 citations

Epigenetic inheritance during the cell cycle

2009 • 761 citations

Gene Body-Specific Methylation on the Active X Chromosome

2007 • 704 citations

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

2009 • 670 citations

Ten Putative Contributors to the Obesity Epidemic

2009 • 670 citations

Fetal programming of coronary heart disease

2002 • 665 citations

DNA methylation and histone modifications: teaming up to silence genes

2005 • 632 citations

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

2008 • 626 citations

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

2009 • 565 citations

Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

2007 • 561 citations

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

2009 • 505 citations

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

2009 • 477 citations

The Foxa family of transcription factors in development and metabolism

2006 • 477 citations

Lamb Birth Weight is Affected by Culture System Utilized during in Vitro Pre-Elongation Development of Ovine Embryos

1995 • 449 citations

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

2008 • 444 citations

Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child

2009 • 444 citations

Comprehensive high-throughput arrays for relative methylation (CHARM)

2008 • 434 citations

Promoter CpG Methylation Contributes to ES Cell Gene Regulation in Parallel with Oct4/Nanog, PcG Complex, and Histone H3 K4/K27 Trimethylation

2008 • 425 citations

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

2009 • 421 citations

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

2008 • 415 citations

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

2009 • 415 citations

DNA methylation and gene expression differences in children conceived in vitro or in vivo

2009 • 395 citations

Towards a new developmental synthesis: adaptive developmental plasticity and human disease

2009 • 390 citations

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

2008 • 389 citations

Developmental programming of CpG island methylation profiles in the human genome

2009 • 386 citations

Genomic patterns of DNA methylation: targets and function of an epigenetic mark

2007 • 377 citations

Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior

2004 • 369 citations

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

2005 • 342 citations

The Embryo and Its Future1

2004 • 315 citations

Long-term effects of culture of preimplantation mouse embryos on behavior

2004 • 276 citations

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

2008 • 267 citations

Sexual dimorphism in environmental epigenetic programming

2009 • 261 citations

Exercise‐induced histone modifications in human skeletal muscle

2009 • 261 citations

Stem cell regulation by polycomb repressors: postponing commitment

2008 • 251 citations

The epigenome: Archive of the prenatal environment

2009 • 238 citations

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome

2008 • 237 citations

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

2009 • 229 citations

The epigenetic magic of histone lysine methylation

2006 • 229 citations

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

2008 • 219 citations

Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease1

2007 • 214 citations

Folic Acid Supplementation during the Juvenile-Pubertal Period in Rats Modifies the Phenotype and Epigenotype Induced by Prenatal Nutrition

2009 • 209 citations

X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

2008 • 204 citations

Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF‐1 gene

2009 • 199 citations

Mechanisms of transcriptional repression by histone lysine methylation

2009 • 194 citations

Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability

2009 • 192 citations

Obesity and metabolic syndrome in histone demethylase JHDM2a‐deficient mice

2009 • 178 citations

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells

2009 • 174 citations

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

2009 • 169 citations

Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin

2009 • 167 citations

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

2008 • 167 citations

Brain Renin-Angiotensin System: Fetal Epigenetic Programming by Maternal Protein Restriction During Pregnancy

2009 • 161 citations

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction

2009 • 150 citations

Dietary Manipulation of Histone Structure and Function

2008 • 141 citations

Is Epigenetics an Important Link between Early Life Events and Adult Disease?

2009 • 140 citations

Methods of DNA methylation analysis

2007 • 132 citations

Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet

2006 • 125 citations

Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo

2008 • 117 citations

Epigenetic Signatures Associated with Different Levels of Differentiation Potential in Human Stem Cells

2009 • 103 citations

Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells

2008 • 100 citations

Inheritance of an Epigenetic Mark: The CpG DNA Methyltransferase 1 Is Required for De Novo Establishment of a Complex Pattern of Non-CpG Methylation

2007 • 88 citations

Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype

2005 • 85 citations

Epigenetic Transgenerational Effects of Endocrine Disruptors on Male Reproduction

2009 • 80 citations

Maternal low protein diet restricted to the preimplantation period induces a gender‐specific change on hepatic gene expression in rat fetuses

2006 • 80 citations

Epigenetic regulatory mechanisms during preimplantation development

2009 • 78 citations

Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus

2008 • 78 citations

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies

2008 • 76 citations

Histone Demethylase JHDM2A Is Involved in Male Infertility and Obesity

2010 • 75 citations

Ovine fetal development is more sensitive to perturbation by the presence of serum in embryo culture before rather than after compaction

2006 • 73 citations

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development

2009 • 69 citations

Modelling the developmental origins of health and disease in the early embryo

2006 • 65 citations

Transcription-Independent Heritability of Induced Histone Modifications in the Mouse Preimplantation Embryo

2009 • 62 citations

Epigenetic reprogramming in mammalian reproduction: Contribution from histone variants

2009 • 58 citations

Epigenetic and replacement roles of histone variant H3.3 in reproduction and development

2009 • 51 citations

Early environmental effects on epigenetic regulation in humans

2009 • 33 citations