The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

2002 • 773 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Regulation of monoubiquitinated PCNA by DUB autocleavage

2006 • 549 citations

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

2006 • 544 citations

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway

2004 • 507 citations

Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage

2006 • 491 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

A unified view of the DNA-damage checkpoint

2002 • 458 citations

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

2005 • 378 citations

The role of DNA breaks in genomic instability and tumorigenesis

2003 • 352 citations

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

1999 • 351 citations

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

2003 • 316 citations

Regulation of ubiquitin-binding proteins by monoubiquitination

2006 • 309 citations

A concise review of DNA damage checkpoints and repair in mammalian cells

2006 • 306 citations

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

2006 • 305 citations

When ubiquitin meets ubiquitin receptors: a signalling connection

2003 • 303 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

Regulation of DNA repair by ubiquitylation

2006 • 270 citations

Interactions between BRCT repeats and phosphoproteins: tangled up in two

2004 • 205 citations

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

2002 • 187 citations

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly

2005 • 167 citations

ATM-Dependent Phosphorylation of ATF2 Is Required for the DNA Damage Response

2005 • 167 citations

The ATM-dependent DNA Damage Signaling Pathway

2005 • 161 citations

MRE11/RAD50/NBS1: complex activities

2004 • 155 citations

DNA double-strand break repair from head to tail

2002 • 152 citations

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

2006 • 149 citations

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

2006 • 118 citations

Molecular Functions of BRCA1 in the DNA Damage Response

2004 • 86 citations

Structure of the Ubiquitin-interacting Motif of S5a Bound to the Ubiquitin-like Domain of HR23B

2004 • 83 citations

Localization of checkpoint and repair proteins in eukaryotes

2004 • 62 citations

RAP80, a Novel Nuclear Protein That Interacts with the Retinoid-related Testis-associated Receptor

2002 • 51 citations

Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor α

2007 • 33 citations

Expression and Assay of Recombinant ATM

2003 • 14 citations