Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

2000 • 15,583 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells

2002 • 484 citations

Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state.

2003 • 479 citations

Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage

1999 • 430 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Immature, but not inactive: the tolerogenic function of immature dendritic cells

2002 • 389 citations

A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection

2001 • 374 citations

Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generatedin vitro from CD34+ hematopoietic progenitor cells

2000 • 337 citations

Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptidesin vivo

1996 • 308 citations

A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer.

2002 • 219 citations

Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides.

1996 • 215 citations

Dendritic Cells

2003 • 214 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

How melanoma cells evade trail-induced apoptosis

2001 • 211 citations

Identification of peptide sequences that potentially trigger HLA‐A2.1‐restricted cytotoxic T lymphocytes

1993 • 195 citations

Dendritic cells and immune-based therapies.

1996 • 180 citations

Phase 1 Study in Patients With Metastatic Melanoma of Immunization With Dendritic Cells Presenting Epitopes Derived From the Melanoma-Associated Antigens MART-1 and gp100

2000 • 179 citations

Phase I Trial Of Intravenous Peptide-Pulsed Dendritic Cells in Patients With Metastatic Melanoma

2001 • 171 citations

Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery

2002 • 171 citations

Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines

1999 • 168 citations

Assays for monitoring cellular immune responses to active immunotherapy of cancer.

2001 • 167 citations

CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens.

2003 • 139 citations

Overcoming resistance of cancer cells to apoptosis

2003 • 127 citations

Functional Dissociation Between Local and Systemic Immune Response During Anti-Melanoma Peptide Vaccination

1998 • 127 citations

The treatment of metastatic melanoma with chemotherapy and biologies

1997 • 124 citations

Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein.

2001 • 113 citations

IL-12: a promising adjuvant for cancer vaccination

2003 • 111 citations

Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell responses to a dendritic cell-based multipeptide vaccine in patients with melanoma.

2003 • 96 citations

CD1 Molecules Efficiently Present Antigen in Immature Dendritic Cells and Traffic Independently of MHC Class II During Dendritic Cell Maturation

2002 • 90 citations

Functional Heterogeneity of Vaccine-Induced CD8+ T Cells

2002 • 87 citations

Primary melanoma tumour regression associated with an immune response to the tumour‐associated antigen melan‐A/MART‐1

2001 • 79 citations

Dendritic Cell/Peptide Cancer Vaccines: Clinical Responsiveness and Epitope Spreading

2000 • 69 citations

Immunization with a tumor-cell-lysate-loaded autologous-antigen-presenting-cell-based vaccine in melanoma

1998 • 65 citations

Clinical response after intradermal immature dendritic cell vaccination in metastatic melanoma is associated with immune response to particulate antigen

2003 • 64 citations

Antimelanoma Activity of CTL Generated from Peripheral Blood Mononuclear Cells After Stimulation with Autologous Dendritic Cells Pulsed with Melanoma gp100 Peptide G209-2M Is Correlated to TCR Avidity

2002 • 64 citations

Immunoregulatory T cells in cancer immunotherapy

2002 • 55 citations

CD11c Integrin Gene Promoter Activity During Myeloid Differentiation

1997 • 49 citations

Phase III trial of melacine?? melanoma theraccine versus combination chemotherapy in the treatment of stage IV melanoma

1997 • 46 citations

Tumor metastasis biopsy as a surrogate marker of response to melanoma immunotherapy

1999 • 29 citations

Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells

2000 • 29 citations

Dendritic cell KLH loading requirements for efficient CD4+ T-cell priming and help to peptide-specific cytotoxic T-cell response, in view of potential use in cancer vaccines

2003 • 23 citations

Epidermal Langerhans' cell induction of immunity against an ultraviolet-induced skin tumour.

1996 • 15 citations

Advances in the non-surgical treatment of melanoma

2002 • 15 citations

Melanoma vaccines: prospects for the treatment of melanoma

1997 • 8 citations

Molecular basis of T-cell dysfunction in melanoma

1997 • 5 citations