Experimental and Preliminary Clinical Evidence of an Ischemic Zone with Prolonged Negative DC Shifts Surrounded by a Normally Perfused Tissue Belt with Persistent Electrocorticographic Depression

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

1944 • 2,580 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

FURTHER OBSERVATIONS ON THE SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

1947 • 906 citations

Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1)

2008 • 597 citations

A new penumbra: transitioning from injury into repair after stroke

2008 • 579 citations

Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations

2006 • 549 citations

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

2009 • 516 citations

Cortical spreading depression causes and coincides with tissue hypoxia

2007 • 444 citations

Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex

2005 • 418 citations

Spreading depolarizations occur in human ischemic stroke with high incidence

2008 • 408 citations

Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

2009 • 403 citations

Extracellular ionic variations during spreading depression

1978 • 387 citations

Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution

2007 • 378 citations

Evaluation of commercially available electrodes and gels for recording of slow EEG potentials

2004 • 311 citations

Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

1993 • 305 citations

Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations

2005 • 305 citations

Potassium-Induced Cortical Spreading Depressions during Focal Cerebral Ischemia in Rats: Contribution to Lesion Growth Assessed by Diffusion-Weighted NMR and Biochemical Imaging

1996 • 277 citations

Mechanism Involved in Initiation and Propagation of Receptor-Induced Intercellular Calcium Signaling in Cultured Rat Astrocytes

1997 • 254 citations

Endothelin-1-Induced Reductions in Cerebral Blood Flow: Dose Dependency, Time Course, and Neuropathological Consequences

1993 • 226 citations

Ions in the Brain

2004 • 207 citations

Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex

2006 • 206 citations

Spreading Depolarizations and Late Secondary Insults after Traumatic Brain Injury

2009 • 191 citations

Endothelin‐1 potently induces Leão’s cortical spreading depression in vivo in the rat

2002 • 183 citations

Rapid Morphologic Plasticity of Peri-Infarct Dendritic Spines After Focal Ischemic Stroke

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Source and cause of endothelin-1 release into cerebrospinal fluid after subarachnoid hemorrhage

1997 • 141 citations

Ions in the Brain: Normal Function, Seizures, and Stroke

2004 • 129 citations

Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO

2005 • 120 citations

Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury

2009 • 117 citations

Enhanced Spontaneous Transmitter Release Is the Earliest Consequence of Neocortical Hypoxia That Can Explain the Disruption of Normal Circuit Function

2001 • 114 citations

Comparative Effects of Propofol, Pentobarbital, and Isoflurane on Cerebral Blood Flow and Blood Volume

1996 • 98 citations

Longitudinal Depolarization Gradients Along the Somatodendritic Axis of CA1 Pyramidal Cells: A Novel Feature of Spreading Depression

2005 • 91 citations

Temporal Relationship Between Endothelin-1 Concentrations and Cerebral Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage

2001 • 89 citations

Increased Extracellular K ⁺ Concentration Reduces the Efficacy of N -methyl- <scp>d</scp> -aspartate Receptor Antagonists to Block Spreading Depression-Like Depolarizations and Spreading Ischemia

2005 • 82 citations

Novel Mechanism of Endothelin-1-Induced Vasospasm after Subarachnoid Hemorrhage

2007 • 72 citations

The role of spreading depression in acute brain disorders.

1984 • 72 citations

Induced Spreading Depression Activates Persistent Neurogenesis in the Subventricular Zone, Generating Cells With Markers for Divided and Early Committed Neurons in the Caudate Putamen and Cortex

2005 • 66 citations

Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis.

2007 • 62 citations

ET-1 induces cortical spreading depression via activation of the ET_Areceptor/phospholipase C pathway in vivo

2004 • 55 citations

G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells

1993 • 47 citations

Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH

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Analysis of Nitric Oxide (NO) in Cerebral Vasospasm After Aneursymal Bleeding

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Contributions of Ca²⁺ and Zn²⁺ to spreading depression‐like events and neuronal injury

2009 • 39 citations

AC Electrocorticographic Correlates of Peri-Infarct Depolarizations during Transient Focal Ischemia and Reperfusion

2005 • 37 citations

Induction of Neurogenesis in the Adult Dentate Gyrus by Cortical Spreading Depression

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Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function

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Changes in extracellular acid-base homeostasis in cerebral ischemia

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The Kety–Schmidt technique for repeated measurements of global cerebral blood flow and metabolism in the conscious rat

1999 • 29 citations

Tachyphylaxis to the vasopressor effects of endothelin in rat aortic rings

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