Spreading Depolarizations and Late Secondary Insults after Traumatic Brain Injury

THE ROLE OF SECONDARY BRAIN INJURY IN DETERMINING OUTCOME FROM SEVERE HEAD INJURY

1993 • 2,123 citations

Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization

2001 • 1,092 citations

Prevention of secondary ischemic insults after severe head injury

1999 • 730 citations

Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring

1999 • 569 citations

Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations

2006 • 549 citations

Measuring the Burden of Secondary Insults in Head-Injured Patients During Intensive Care

1994 • 496 citations

Characterization of cerebral hemodynamic phases following severe head trauma: hypoperfusion, hyperemia, and vasospasm

1997 • 481 citations

Cortical spreading depression activates and upregulates MMP-9

2004 • 446 citations

Jugular venous desaturation and outcome after head injury.

1994 • 444 citations

Spreading and Synchronous Depressions of Cortical Activity in Acutely Injured Human Brain

2002 • 423 citations

Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex

2005 • 418 citations

Early and Late Systemic Hypotension as a Frequent and Fundamental Source of Cerebral Ischemia Following Severe Brain Injury in the Traumatic Coma Data Bank

1993 • 413 citations

Cortical spreading depression activates and upregulates MMP-9

2004 • 413 citations

Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis

2007 • 410 citations

Spreading depolarizations occur in human ischemic stroke with high incidence

2008 • 408 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

Early Indicators of Prognosis in 846 Cases of Severe Traumatic Brain Injury

2002 • 320 citations

Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations

2005 • 305 citations

Potassium-Induced Cortical Spreading Depressions during Focal Cerebral Ischemia in Rats: Contribution to Lesion Growth Assessed by Diffusion-Weighted NMR and Biochemical Imaging

1996 • 277 citations

Incidence and Mechanisms of Cerebral Ischemia in Early Clinical Head Injury

2004 • 263 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain

2008 • 213 citations

Delayed Secondary Phase of Peri-Infarct Depolarizations after Focal Cerebral Ischemia: Relation to Infarct Growth and Neuroprotection

2003 • 207 citations

Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex

2006 • 206 citations

Temperature Modulation of Cerebral Depolarization during Focal Cerebral Ischemia in Rats: Correlation with Ischemic Injury

1993 • 201 citations

Cerebral blood flow, arteriovenous oxygen difference, and outcome in head injured patients.

1992 • 173 citations

Cerebral blood flow as a predictor of outcome following traumatic brain injury

1997 • 168 citations

Prognostic Value of Admission Blood Pressure in Traumatic Brain Injury: Results from The IMPACT Study

2007 • 164 citations

Continuous EEG monitoring in the intensive care unit: an overview.

2004 • 161 citations

Occurrence of Potentially Detrimental Temperature Alterations in Hospitalized Patients at Risk for Brain Injury

1998 • 147 citations

Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia

2003 • 132 citations

Persisting Depletion of Brain Glucose following Cortical Spreading Depression, despite Apparent Hyperaemia: Evidence for Risk of an Adverse Effect of Leão's Spreading Depression

2008 • 101 citations

Alterations in the microenvironment during spreading depression associated with epileptiform activity in the immature neocortex

1989 • 98 citations

Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis

2007 • 81 citations

Depolarisation Phenomena in Traumatic and Ischaemic Brain Injury

2005 • 71 citations

Severe traumatic head injury in adults: Which patients are at risk of early hyperthermia?

2004 • 61 citations

Recurring episodes of spreading depression are spontaneously elicited by an intracerebral hemorrhage in the swine

2001 • 54 citations

Comparison of Cerebral Blood Flow in Computed Tomographic Hypodense Areas of the Brain in Head-injured Patients

2003 • 49 citations

Repetitive cortical spreading depolarizations in a case of severe brain trauma

2008 • 40 citations

Cause, distribution and significance of episodes of reduced cerebral perfusion pressure following head injury

1994 • 36 citations

Peri-Infarct Depolarizations Reveal Penumbra-Like Conditions in Striatum

2005 • 32 citations

Arterial hypotension triggers perifocal depolarizations and aggravates secondary damage in focal brain injury

2006 • 16 citations

Spreading Depression Induces Permanent Cell Swelling Under Penumbra Conditions

2000 • 15 citations