Sequence features that correlate with MHC restriction

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

Determinant Selection and Macrophage Function in Genetic Control of the Immune Response

1978 • 389 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

1992 • 295 citations

Hydrogen bond stereochemistry in protein structure and function

1990 • 270 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.

1988 • 264 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

The Choice of T‐Cell Epitopes Utilized on a Protein Antigen Depends on Multiple Factors Distant from, as well as at the Determinant Site

1987 • 247 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

1986 • 221 citations

Finding sequence motifs in groups of functionally related proteins.

1990 • 208 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Immune response to the pre-S(1) region of the hepatitis B surface antigen (HBsAg): a pre-S(1)-specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg.

1986 • 183 citations

Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide.

1987 • 175 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

Mapping of T cell epitopes using recombinant antigens and synthetic peptides.

1987 • 152 citations

Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.

1988 • 146 citations

H-2Kd-restricted antigenic peptides share a simple binding motif.

1991 • 145 citations

Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope.

1988 • 141 citations

The Structure of T-Cell Epitopes

1987 • 130 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

1993 • 117 citations

An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself.

1990 • 110 citations

Molecular mapping of a histocompatibility-restricted immunodominant T cell epitope with synthetic and natural peptides: implications for T cell antigenic structure.

1986 • 105 citations

The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency.

1985 • 102 citations

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG

1988 • 101 citations

Immunological Priming with Synthetic Peptides of Foot-and-Mouth Disease Virus

1985 • 99 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

I-Ad-binding peptides derived from unrelated protein antigens share a common structural motif.

1988 • 94 citations

Specificity of the T cell immune response to acetylcholine receptor in experimental autoimmune myasthenia gravis. Response to subunits and synthetic peptides.

1988 • 92 citations

T cell clones specific for an amphipathic alpha-helical region of sperm whale myoglobin show differing fine specificities for synthetic peptides. A multiview/single structure interpretation of immunodominance.

1986 • 86 citations

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif.

1992 • 85 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C.

1983 • 80 citations

Structural analysis of a peptide-HLA class II complex: identification of critical interactions for its formation and recognition by T cell receptor

1989 • 78 citations

The T cell repertoire for recognition of a phylogenetically distant protein antigen. Peptide specificity and MHC restriction of staphylococcal nuclease-specific T cell clones.

1986 • 78 citations

Immunological focusing by the mouse major histocompatibility complex: Mouse strains confronted with distantly related lysozymes confine their attention to very few epitopes

1982 • 78 citations

Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide.

1986 • 78 citations

T cell multideterminant regions in the human immunodeficiency virus envelope: toward overcoming the problem of major histocompatibility complex restriction

1989 • 75 citations

Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein

1988 • 74 citations

Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

1985 • 74 citations

A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

1987 • 69 citations

T lymphocyte response to bacteriophage lambda repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypes.

1987 • 68 citations

T cell responses to cleaved rabies virus glycoprotein and to synthetic peptides.

1984 • 67 citations

T-cell activation by peptide antigen: effect of peptide sequence and method of antigen presentation.

1985 • 61 citations

Synthetic peptides and β‐chain gene rearrangements reveal a diversified T cell repertoire for a λ light chain third hypervariable region

1986 • 61 citations

Epitopes Recognized by Human T Cells Map Within the Conserved Part of the GP190 ofP. Falciparum

1988 • 61 citations

A limited region within hen egg-white lysozyme serves as the focus for a diversity of T cell clones.

1984 • 56 citations

T-cell epitopes in Pf155/RESA, a major candidate for a Plasmodium falciparum malaria vaccine.

1988 • 51 citations

Analysis of peptide residues interacting with MHC molecule or T cell receptor. Can a peptide bind in more than one way to the same MHC molecule?

1990 • 51 citations

Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein.

1988 • 48 citations

Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide.

1988 • 44 citations

Fine specificity of genetic regulation of guinea pig T lymphocyte responses to angiotensin II and related peptides

1981 • 40 citations

Comparison of structural requirements for interaction of the same peptide with I-Ek and I-Ed molecules in the activation of MHC class II-restricted T cells.

1991 • 40 citations

The location of regions in guinea pig and bovine myelin basic proteins which induce experimental allergic encephalomyelitis in Lewis rats.

1975 • 39 citations

Major histocompatibility complex-controlled, antigen-presenting cell-expressed specificity of T cell antigen recognition. Identification of a site of interaction and its relationship to Ir genes.

1983 • 39 citations

The Location of Regions in Guinea Pig and Bovine Myelin Basic Proteins Which Induce Experimental Allergic Encephalomyelitis in Lewis Rats

1975 • 39 citations

Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). VI. T cell fine specificity.

1985 • 38 citations

Role of receptor-binding activity of the viral hemagglutinin molecule in the presentation of influenza virus antigens to helper T cells

1987 • 38 citations

The pigeon cytochrome c-specific T cell response of low responder mice. I. Identification of antigenic determinants on fragment 1 to 65.

1986 • 35 citations

Immunogenicity of protein antigens : repertoire and regulation

1987 • 32 citations

Fine specificity of T cell recognition of the same peptide in association with different I-A molecules.

1989 • 30 citations

Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone.

1989 • 29 citations

Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease.

1991 • 28 citations

Modification of the T cell responsiveness to synthetic peptides by substituting amino acids on agretopes

1990 • 27 citations

Immunity to hepatitis B: analysis of antibody and cellular responses in recipients of a plasma-derived vaccine using synthetic peptides mimicking S and pre-S regions.

1988 • 26 citations

Immune Response to Synthetic Herpes Simplex Virus Peptides:The Feasibility of a Synthetic Vaccine

1986 • 25 citations

Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.

1988 • 24 citations

Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein.

1988 • 23 citations

Identification of Mycobacterial Antigens Recognized by T Lymphocytes

1989 • 20 citations

Proliferating and helper T lymphocytes display distinct fine specificities in response to human fibrinopeptide B.

1983 • 20 citations

Multiple T cell antigenic determinants identified within a limited region of the horse cytochrome c molecule

1987 • 20 citations

Determinant selection and macrophage function

1982 • 18 citations

Analysis of lysozyme‐specific immune responses by synthetic peptides. I. Characterization of antibody and T cell‐mediated responses to the N‐terminal peptide of hen egg‐white lysozyme

1986 • 17 citations

Fine specificity of a BALB/c T cell clone directed against beef apo cytochrome c

1983 • 16 citations

Clonal analysis of the BALB/c T cell proliferative response to apo beef cytochrome c.

1981 • 14 citations

Alloantigenic sites on class I major histocompatibility complex antigens: 61-69 region in the first domain of the H-2Kb molecule induces specific antibody and T cell responses.

1986 • 10 citations

Fine specificity analysis of lactate dehydrogenase B‐specific proliferating T cell clones: implications for the mechanism of alloreactivity

1985 • 9 citations

Characterization of a helper T cell epitope recognized by mice of a low responder major histocompatibility type

1990 • 5 citations

Emerging principles for vaccine development: Antigen processing and presentation

1993 • 1 citations