Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope.

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

Immune responses in vitro. I. Culture conditions for antibody synthesis

1972 • 426 citations

Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.

1982 • 395 citations

The Nucleocapsid of Hepatitis B Virus Is Both a T-Cell-Independent and a T-Cell-Dependent Antigen

1986 • 363 citations

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

1987 • 319 citations

A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.

1986 • 239 citations

Immunochemical structure of hepatitis B e antigen in the serum.

1983 • 217 citations

Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin.

1984 • 214 citations

Antibodies to a synthetic peptide from the preS 120–145 region of the hepatitis B virus envelope are virus-neutralizing

1986 • 210 citations

Structural Relationships Between Minor and Major Proteins of Hepatitis B Surface Antigen

1983 • 196 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen.

1981 • 147 citations

Hepatitis B virus antigens made in microbial cells immunise against viral infection.

1984 • 144 citations

Hepatitis B virus core antigen: synthesis in Escherichia coli and application in diagnosis.

1982 • 133 citations

Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). I. H-2 restriction of the murine humoral immune response to the a and d determinants of HBsAg.

1982 • 120 citations

A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

1987 • 69 citations

Summary of an International Workshop on Hepatitis B Vaccines

1979 • 56 citations

Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues.

1986 • 47 citations