The evolution of antihypertensive therapy: An overview of four decades of experience

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

The Natural History of Congestive Heart Failure: The Framingham Study

1971 • 3,350 citations

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

1984 • 3,130 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

STUDIES ON EXPERIMENTAL HYPERTENSION

1934 • 2,092 citations

MORTALITY AND MORBIDITY RESULTS FROM THE EUROPEAN WORKING PARTY ON HIGH BLOOD PRESSURE IN THE ELDERLY TRIAL*1, *2

1985 • 1,482 citations

Effects Morbidity of Treatment on in Hypertension

1970 • 1,278 citations

Five-Year Findings of the Hypertension Detection and Follow-up Program

1979 • 1,212 citations

The 1988 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure

1988 • 1,091 citations

Epidemiology of coronary heart disease: The Framingham study

1984 • 1,072 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Medicine and the Law

1969 • 849 citations

The Heart in Hypertension

1992 • 774 citations

Left Ventricular Hypertrophy by Electrocardiogram

1969 • 762 citations

Propranolol Inhibition of Renin Secretion

1972 • 729 citations

Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril.

1985 • 726 citations

BENEFITS AND POTENTIAL HARM OF LOWERING HIGH BLOOD PRESSURE

1987 • 660 citations

A placebo-controlled trial of captopril in refractory chronic congestive heart failure

1983 • 562 citations

Diltiazem and Reinfarction in Patients with Non-Q-Wave Myocardial Infarction

1986 • 539 citations

The Australian therapeutic trial in mild hypertension.

1984 • 528 citations

Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.

1981 • 511 citations

A Specific Sympathomimetic Ergone in Adrenergic Nerve Fibres (Sympathin) and its Relations to Adrenaline and Nor‐Adrenaline

1946 • 502 citations

Overview of Results of Randomized Clinical Trials in Heart Disease

1988 • 501 citations

Salt, volume and the prevention of hypertension.

1976 • 489 citations

Beta-Blockers Versus Diuretics in Hypertensive Men: Main Results from the HAPPHY Trial

1987 • 477 citations

The pharmacological basis of therapeutics. 6th ed

1981 • 470 citations

Treatment of Hypertension with Propranolol

1969 • 426 citations

Use of Propranolol (Inderal) in Treatment of Hypertension

1964 • 407 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

The spectrum of left ventricular hypertrophy in a general population sample: the Framingham Study.

1987 • 391 citations

Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure

1980 • 380 citations

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.

1958 • 373 citations

Converting-Enzyme Inhibitors in the Treatment of Hypertension

1988 • 362 citations

Cardiovascular Risk and Risk Factors in a Randomized Trial of Treatment Based on the Beta-Blocker Oxprenolol: The International Prospective Primary Prevention Study in Hypertension (IPPPSH)

1985 • 348 citations

The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: A review of randomized controlled trials

1986 • 342 citations

Pharmacology of Antihypertensive Drugs.

1980 • 330 citations

Arteriosclerosis Obliterans: Review of 520 Cases with Special Reference to Pathogenic and Prognostic Factors

1960 • 307 citations

Pathophysiologic assessment of hypertensive heart disease with echocardiography

1977 • 294 citations

Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic Blockade

1972 • 274 citations

The Paradox of Beta-Adrenergic Blockade in Hypertension

1968 • 265 citations

Vasodilator Drugs in the Treatment of Hypertension

1974 • 263 citations

Surgery's Relevance to an Understanding of Basic Biology

1967 • 258 citations

Decarboxylase Inhibition and Blood Pressure Reduction by α-Methyl-3,4-Dihydroxy-DL-phenylalanine

1960 • 254 citations

Potent new inhibitors of human renin

1982 • 239 citations

Hyperdynamic ß-Adrenergic Circulatory State

1969 • 236 citations

Controlled trial of captopril in chronic heart failure: a rest and exercise hemodynamic study.

1983 • 234 citations

THE AUSTRALIAN THERAPEUTIC TRIAL IN MILD HYPERTENSION

1980 • 234 citations

β-Adrenoceptor Antagonists: New Drugs and New Indications

1981 • 231 citations

Intermittent claudication — its natural course

1976 • 215 citations

THE PHARMACOLOGY OF ADRENERGIC BLOCKADE

1949 • 203 citations

Combined Therapy with Vasodilator Drugs and Beta-Adrenergic Blockade in Hypertension

1972 • 200 citations

False Adrenergic Transmitters

1968 • 197 citations

Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management

1973 • 190 citations

Studies on the Control of Hypertension by Hyphex

1953 • 190 citations

Cardiovascular Morbidity in Relation to Change in Blood Pressure and Serum Cholesterol Levels in Treated Hypertension

1987 • 188 citations

Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension

1973 • 184 citations

THE METHONIUM COMPOUNDS

1952 • 183 citations

Nadolol

1980 • 183 citations

Adrenergic Neurone Blocking Agents

1965 • 178 citations

Hyperdynamic beta-adrenergic circulatory state. Increased beta-receptor responsiveness

1969 • 175 citations

Six-Year Follow-up of the Norwegian Multicenter Study on Timolol after Acute Myocardial Infarction

1985 • 173 citations

Hyperdynamic Beta-Adrenergic Circulatory State

1966 • 170 citations

Hyperkalemia in azotemic patients during angiotensin-converting enzyme inhibition and aldosterone reduction with captopril

1982 • 169 citations

The Effects of Antihypertensive Agents on Serum Lipids and Lipoproteins

1988 • 169 citations

Preganglionic sympathetic activity in normal and in reserpine‐treated cats

1960 • 169 citations

Dependence of Arterial Pressure on Intravascular Volume in Treated Hypertensive Patients

1972 • 161 citations

Centrally mediated decrease in sympathetic tone induced by 2(2,6-dichlorophenylamino)-2 imidazoline (S.T. 155, Catapresan)

1967 • 154 citations

Pharmacology of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (Su-5864).

1960 • 150 citations

Unrecognized myocardial infarction and hypertension: The Framingham Study

1985 • 149 citations

The pharmacology of adrenergic blockade.

1949 • 144 citations

Prazosin: the first-dose phenomenon.

1976 • 143 citations

Central nervous system effects of four β-adrenergic receptor blocking agents

1966 • 130 citations

Immediate and short-term hemodynamic effects of diltiazem in patients with hypertension.

1986 • 129 citations

Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin.

1988 • 120 citations

Effect of vasodilators on survival in chronic congestive heart failure

1985 • 120 citations

Effect of methyldopa, clonidine, and hydralazine on cardiac mass and haemodynamics in Wistar Kyoto and spontaneously hypertensive rats

1982 • 118 citations

Cardiovascular effects of verapamil in patients with essential hypertension.

1987 • 117 citations

Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist fenoldopam.

1987 • 116 citations

Time course of regression of left ventricular hypertrophy in hypertensive patients treated with atenolol.

1987 • 115 citations

Plasma Volume Expansion Resulting from Interference with Adrenergic Function in Normal Man

1968 • 111 citations

Hypertension and Sudden Death

1989 • 108 citations

Coronary heart disease death, nonfatal acute myocardial infarction and other clinical outcomes in the multiple risk factor intervention trial

1986 • 107 citations

Central hypotensive effect of α-methyldopa

1968 • 103 citations

Hemodynamic effects of labetalol, an alpha and beta adrenergic blocking agent, in hypertensive subjects.

1977 • 101 citations

Hemodynamic comparison of agents useful in hypertensive emergencies

1973 • 100 citations

Persistence of Reduction in Blood Pressure and Mortality of Participants in the Hypertension Detection and Follow-up Program

1988 • 100 citations

Antihypertensive Agents.

1968 • 98 citations

Pindolol: A New β-Adrenoceptor Antagonist with Partial Agonist Activity

1983 • 97 citations

Effects of diltiazem on serum lipids, exercise performance and blood pressure: Randomized, double-blind, placebo-controlled evaluation for systemic hypertension

1985 • 96 citations

Comparison of captopril and hydrochlorothiazide alone and in combination in mild to moderate essential hypertension.

1982 • 96 citations

Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline

1971 • 95 citations

THE HEMODYNAMIC EFFECTS OF HYPOTENSIVE DRUGS IN MAN. III. HEXAMETHONIUM 123

1953 • 92 citations

Inhibition of Angiotensin-Converting Enzyme for Diagnosis of Renal-Artery Stenosis

1978 • 92 citations

Alpha-Adrenergic Receptor Blockade with Prazosin

1982 • 90 citations

Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension

1985 • 90 citations

Clonidine: A new antihypertensive agent

1971 • 87 citations

Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension.

1984 • 84 citations

Effect of Methyldopa on Plasma Renin Activity in Man

1969 • 82 citations

ON THE NATURE OF THE PRESSOR ACTION OF RENIN

1939 • 79 citations

Hydralazine and Plasma Renin Activity

1968 • 79 citations

Immediate and short-term hemodynamic effects of diltiazem in patients with hypertension.

1986 • 75 citations

Circulatory effects of sympathomimetic amines

1962 • 73 citations

Metoprolol

1977 • 71 citations

Suddent cardic death— Management of the patient at risk

1980 • 70 citations

The use of propranolol in the treatment of hypertension.

1973 • 70 citations

Captopril in patients with type II diabetes and renal insufficiency: Systemic and renal hemodynamic alterations

1988 • 70 citations

Circulatory Effects of Guanethidine

1960 • 70 citations

Platelet α2-Adrenergic Receptors in Treated and Untreated Essential Hypertension

1983 • 67 citations

Pathophysiologic assessment of left ventricular hypertrophy and strain in asymptomatic patients with essential hypertension

1989 • 65 citations

Clinical pharmacology of slow channel blocking agents

1982 • 61 citations

Intravenous labetalol in the management of severe hypertension and hypertensive emergencies

1984 • 60 citations

Hemodynamic Effects of Methyldopa (Aldomet®) at Rest and during Exercise in Patients with Arterial Hypertension

1962 • 59 citations

Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide.

1975 • 57 citations

Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory.

1977 • 56 citations

Minoxidil-Induced Hypertrichosis

1977 • 55 citations

Serum lipoprotein changes during atenolol treatment of essential hypertension

1981 • 55 citations

Systemic and regional hemodynamic and humoral effects of nitrendipine in essential hypertension.

1988 • 55 citations

Myocardial Ischemia

1977 • 52 citations

Effect of drug therapy on survival in chronic congestive heart failure

1988 • 51 citations

Diltiazem maintains renal vasodilation without hyperfiltration in hypertension: Studies in essential hypertensive man and the spontaneously hypertensive rat

1987 • 51 citations

Autonomic Nervous System and Benign Essential Hypertension in Man

1974 • 51 citations

The first Irvine H. Page lecture The mosaic of hypertension

1988 • 51 citations

A Comparison of the Cardiovascular Effects of Sodium Nitroprusside and Trimethaphan

1977 • 50 citations

Hemodynamic factors in the pathogenesis and maintenance of hypertension.

1982 • 50 citations

CARDIOVASCULAR AND RENAL HEMODYNAMIC RESPONSE TO RESERPINE (SERPASIL), AND CLINICAL RESULTS OF USING THIS AGENT FOR THE TREATMENT OF HYPERTENSION

1954 • 50 citations

Current concepts in treatment of hypertensive emergencies

1986 • 49 citations

The effects of alpha-methyldopa on renal function in hypertensive patients

1968 • 49 citations

Some pharmacodynamic effects of 1-hydrazinophthalazine (C-5968) with particular reference to renal function and cardiovascular response.

1951 • 46 citations

Regression of left ventricular hypertrophy in two-kidney, one clip Goldblatt hypertension.

1982 • 44 citations

Disparate Effects of Methyldopa and Clonidine on Cardiac Mass and Haemodynamics in Rats

1980 • 43 citations

Treatment of Severe Hypertension with Minoxidil: Advantages and Limitations

1979 • 42 citations

Renal Hemodynamic Consequences of Angiotensin-Converting Enzyme Inhibition in Congestive Heart Failure

1989 • 42 citations

Angiotensin converting enzyme inhibitors. Present and future.

1989 • 41 citations

Hemodynamics, biochemical and reflexive changes produced by atenolol in hypertension.

1982 • 39 citations

Occult Systemic Lupus Erythematosus in Elderly Men

1983 • 38 citations

Relationships Between the Release and Tissue Depletion of Norepinephrine from the Heart by Guanethidine and Reserpine

1963 • 38 citations

A Double Blind Control Study of Antihypertensive Agents

1960 • 38 citations

A highly potent and long-acting oral inhibitor of human renin.

1988 • 36 citations

Pathophysiology: Altered Regulatory Mechanisms in Disease.

1985 • 36 citations

EFFECT OF HYPOTENSION-PRODUCING DRUGS ON THE RENAL CIRCULATION

1952 • 35 citations

Goals of Antihypertensive Therapy

1989 • 35 citations

Hemodynamic and endocrine changes associated with captopril in diuretic-resistant hypertensive patients

1982 • 34 citations

Effects of prazosin in patients with hypertension

1976 • 34 citations

The central action of clonidine and its antagonism

1972 • 33 citations

Importance of Left Ventricular Mass as a Predictor of Cardiovascular Morbidity in Hypertension

1989 • 33 citations

Low-Dose Captopril

1982 • 30 citations

Ventricular performance in spontaneously hypertensive rats (SHR) with reduced cardiac mass

1989 • 28 citations

Analysis of the Acute Circulatory Effects of Guanethidine and Bretylium

1962 • 27 citations

The acute hemodynamic effects of α-methyldopa in man

1962 • 27 citations

Cardiovascular and Renal Responses to the Combination of Hexamethonium and 1-Hydrazinophthalazine (Apresoline®) in Hypertensive Subjects1

1955 • 26 citations

Inhibition of Adrenergic Function in the Treatment of Hypertension

1974 • 25 citations

Protective Action of Calcium Channel Antagonists in Atherogenesis and Experimental Vascular Injury

1989 • 25 citations

Systolic Hypertension in the Elderly Program, Pilot Study (SHEP-PS): morbidity and mortality experience.

1986 • 24 citations

Captoril

1982 • 24 citations

Diuretics in Hypertension

1987 • 23 citations

Double Blind Control Study of Antihypertensive Agents

1962 • 23 citations

Hypertension update : mechanisms epidemiology evaluation management

1980 • 23 citations

The effects of antihypertensive agents on serum lipids and lipoproteins

1988 • 23 citations

Renal response to angiotensin-converting enzyme inhibition

1982 • 22 citations

The renal, forearm, and hormonal responses to standing in the presence and absence of propranolol.

1986 • 21 citations

Beta-adrenergic blocking therapy in hypertension: selection of patients.

1970 • 21 citations

Pheochromocytoma — Recognition and management

1979 • 21 citations

Effects of Calcium Channel Antagonists and Other Antihypertensive Drugs on Atherogenesis

1987 • 20 citations

Regression of left ventricular hypertrophy in two-kidney, one clip Goldblatt hypertension

1982 • 19 citations

Diuretic agents versus beta-blockers. Comparison of effects on mortality, stroke, and coronary events.

1989 • 18 citations

Renal function in patients with essential hypertension receiving nadolol.

1980 • 18 citations

The heart in hypertension: unresolved conceptual challenges. Special lecture.

1988 • 18 citations

Hemodynamic effects of intravenous labetalol in essential hypertension

1983 • 17 citations

Calcium Antagonists in Patients with Cardiovascular Disease

1985 • 16 citations

Treating hypertension: A review of clinical trials

1986 • 15 citations

THE L. E. CELL AS A MANIFESTATION OF DELAYED HYDRALAZINE INTOXICATION

1956 • 15 citations

Minoxidil-Induced Systemic Lupus Erythematosus

1987 • 15 citations

Hyperdynamic Beta-Adrenergic

1970 • 14 citations

Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension

1984 • 14 citations

Hypertension and Angina Pectoris

1978 • 14 citations

Arterial vasodilators, cardiac volume load, and cardiac hypertrophy in normotensive rats

1989 • 13 citations

The phase diagram of cetomacrogol 1000—water–benzaldehyde in the presence of gallate antioxidants

1971 • 11 citations

Metoprolol: A Review of its Pharmacological Properties and Therapeutic Efficacy in Hypertension

1979 • 10 citations

Introduction

1985 • 10 citations

Reduction of the Hypotensive Effect of Clonidine and α-Methyldopa by Various Psychotropic Drugs

1976 • 10 citations

Renal Failure Associated With Captopril

1983 • 9 citations

Comparison of the effects of captopril, diuretic and their combination in low- and normal-renin essential hypertension

1982 • 8 citations

Diuretics as antihypertensive drugs.

1988 • 6 citations

Calcium antagonists variably change cardiovascular mass and improve function in rats

1990 • 5 citations

Hospital Junior Staff

1965 • 5 citations

PATHOPHYSIOLOGY : altered regulatory mechanisms in disease, 3rd ed.

1984 • 2 citations