Dopamine, neuroleptics and reinforced behavior

Parkinsonism

1967 • 11,463 citations

Principles of Behavior

1944 • 4,124 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

Psychology

1962 • 1,950 citations

The Pharmacological Basis for Therapeutics

1981 • 1,896 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

Psychiatric Aspects of Neurologic Disease

1976 • 674 citations

Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

1978 • 643 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

A motivational view of learning, performance, and behavior modification.

1974 • 559 citations

Dopaminergic substrates of amphetamine-induced place preference conditioning

1982 • 381 citations

Drug discrimination and state dependent learning

1978 • 347 citations

Stimulus Properties of Drugs

1972 • 336 citations

Conditioned Cues Elicit Feeding in Sated Rats: A Role for Learning in Meal Initiation

1983 • 333 citations

Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficits

1976 • 320 citations

Partial Reinforcement Effects On Vigor and Persistence

1967 • 286 citations

Partial reinforcement: a review and critique.

1950 • 282 citations

Drug reinstatement of heroin-reinforced responding in the rat

1983 • 266 citations

Reinforcing effects of brain microinjections of morphine revealed by conditioned place preference

1982 • 238 citations

Partial reinforcement: A selective review of the literature since 1950.

1960 • 230 citations

Neuroleptic-induced attenuation of brain stimulation reward in rats.

1978 • 229 citations

Problems of measurement and interpretation with reinforcing brain stimulation.

1964 • 223 citations

The Control of Ingestive Behaviour by Internal and External Stimuli—A Theoretical Review

1981 • 211 citations

Reward value of a non-nutritive sweet taste.

1950 • 210 citations

Behavioral Pharmacology

1961 • 202 citations

An incentive model of rewarding brain stimulation.

1969 • 199 citations

Pimozide-induced extinction in rats: Stimulus control of responding rules out motor deficit

1979 • 186 citations

Dynamics of response

1965 • 185 citations

Attenuation by haloperidol of place preference conditioning using food reinforcement

1982 • 179 citations

Discriminating between reward and performance: A critical review of intracranial self-stimulation methodology

1983 • 174 citations

Decreased resistance to extinction after haloperidol: Implications for the role of dopamine in reinforcement

1979 • 166 citations

Response Artifact in the Measurement of Neuroleptic-Induced Anhedonia

1981 • 165 citations

Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine.

1968 • 164 citations

Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?

1983 • 146 citations

The use of conditioned suppression to evaluate the nature of neuroleptic-induced avoidance deficits.

1980 • 145 citations

The Comparative Pharmacology of Flupenthixol and some Reference Neuroleptics

1973 • 133 citations

An evaluation of response rate as a measure of rewarding intracranial stimulation.

1962 • 130 citations

Effects of dopamine receptor blockade on alimentary behaviors: Home cage food consumption, magazine training, operant acquisition, and performance

1979 • 128 citations

Extinction and dopamine receptor blockade after intermittent reinforcement training: Failure to observe functional equivalence

1980 • 118 citations

Does pimozide block the reinforcing effect of brain stimulation?

1982 • 117 citations

The effect of pimozide on the establishment of conditioned reinforcement

1980 • 115 citations

Effects of pimozide on lever pressing behavior maintained on an intermittent reinforcement schedule

1980 • 110 citations

A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs

1979 • 108 citations

Haloperidol induces a partial reinforcement extinction effect in rats: Implications for a dopamine involvement in food reward

1986 • 106 citations

Conditioned aversion to distinct environmental stimuli resulting from gastrointestinal distress.

1973 • 104 citations

The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the rat

1981 • 101 citations

Escape from Self-Produced Rates of Brain Stimulation

1969 • 100 citations

Different effects of haloperidol and extinction on instrumental behaviours

1986 • 97 citations

Opiates as Reinforcing Stimuli

1971 • 91 citations

Self-Stimulation of the Brain Used as a Screening Method for Tranquilizing Drugs

1956 • 88 citations

Interactive effects of brain catecholamines and variations in sexual and non-sexual arousal on copulatory behavior of male rats

1976 • 85 citations

Reward, performance, and the response strength method in self-stimulating rats: Validation and neuroleptics

1985 • 83 citations

Psychotropic drug side effects : clinical and theoretical perspectives

1970 • 79 citations

Haloperidol blocks the response-reinstating effects of food reward: A methodology for separating neuroleptic effects on reinforcement and motor processes

1988 • 77 citations

Effects of apomorphine and haloperidol on exploratory behavior and latent learning in mice

1977 • 76 citations

The use of conditioned defensive burying to test the effects of pimozide on associative learning

1980 • 74 citations

Parkinsonism induced by dopaminergic antagonists.

1975 • 73 citations

Performance effects with repeated-response measures during pimozide-produced dopamine receptor blockade

1979 • 72 citations

Behavioral Actions of Neuroleptics

1978 • 68 citations

Discriminative and motor performance in rats after interference with dopamine neurotransmission with spiroperidol

1977 • 67 citations

A partial reinforcement extinction effect in water-reinforced rats intermittently treated with haloperidol

1986 • 62 citations

The effects of haloperidol on the partial reinforcement extinction effect (PREE): implications for neuroleptic drug action on reinforcement and nonreinforcement

1988 • 60 citations

The abolition of the partial reinforcement extinction effect (PREE) by amphetamine: Disruption of control by nonreinforcement

1987 • 58 citations

Blockade by neuroleptics of water intake and operant responding for water in the rat: Anhedonia, motor deficit, or both?

1987 • 57 citations

Effects of pimozide on sucrose consumption and preference

1987 • 57 citations

Effects of haloperidol on the biophysical characteristics of operant responding: Implications for motor and reinforcement processes

1986 • 54 citations

Short-term memory in the rhesus monkey: Effects of dopamine blockade via acute haloperidol administration

1978 • 51 citations

How incentive and deficit determine feeding tendency

1975 • 49 citations

Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin

1979 • 49 citations

Effects of haloperidol and d-amphetamine on perceived quantity of foods and tones

1987 • 39 citations

Self-stimulation response decrement patterns differentiate clonidine, baclofen and dopamine antagonists from drugs causing performance deficit

1982 • 38 citations

Effects of neuroleptics on rate and duration of operant versus reflexive licking in rats

1985 • 37 citations

Effects of dexamethasone, corticosterone, and ACTH on lordosis in ovariectomized and adrenalectomized-ovariectomized rats

1980 • 34 citations

Methods for evaluating treatment in Parkinson's disease.

1983 • 34 citations

Haloperidol blocks the conditioned place preferences induced by rewarding brain stimulation.

1988 • 31 citations

Investigation of food selection and meal parameters during the development of dietary-induced obesity

1980 • 30 citations

Effects of pimozide on appetitive behavior and locomotor activity: Dissimilarity of effects when compared to extinction

1986 • 27 citations

Effects of pimozide on emitted force, duration and rate of operant response maintained at low and high levels of required force

1986 • 26 citations

Haloperidol blocks the conditioned place preferences induced by rewarding brain stimulation.

1988 • 26 citations

Effects of pimozide, across doses and within sessions, on discriminated lever release performance in rats

1988 • 24 citations

A minicomputer system for recording the dynamic properties of individual operant responses

1974 • 20 citations

Spatial Avoidance in a Paradigm in Which Ionizing Irradiation Precedes Spatial Confinement

1966 • 19 citations

The measurement of reinforcing brain stimulation

1974 • 18 citations

Response involvement in brain stimulation reward

1981 • 18 citations

The “neuroleptic” antipsychotic drugs

1979 • 15 citations

The importance of subject control in reinforcing brain stimulation

1974 • 15 citations

The “neuroleptic” antipsychotic drugs

1979 • 14 citations

Animal preference for method of obtaining reinforcing brain stimulation.

1964 • 13 citations

Conditioned taste preference and response rate as measures of brain-stimulation reward: A comparison

1980 • 13 citations

Subject control as a determinant of the reinforcing properties of intracranial stimulation☆

1984 • 11 citations

Amplitude measures of operant response: Implementation with Apple Pascal

1985 • 11 citations

Persistence of relapse of morphine-seeking behavior in rats: the relative role of certain biological variables

1976 • 9 citations