Targeting immune effector molecules to human tumor cells through genetic delivery of 5T4-specific scFv fusion proteins

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

1992 • 824 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

1999 • 650 citations

Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial.

1998 • 530 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

European Phase II Study of Rituximab (Chimeric Anti-CD20 Monoclonal Antibody) for Patients With Newly Diagnosed Mantle-Cell Lymphoma and Previously Treated Mantle-Cell Lymphoma, Immunocytoma, and Small B-Cell Lymphocytic Lymphoma

2000 • 485 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.

2000 • 372 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

1991 • 342 citations

Human Immune Respone to Monoclonal Antibodies

1994 • 297 citations

Overview of the clinical development of rituximab: first monoclonal antibody approved for the treatment of lymphoma.

1999 • 286 citations

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.

1993 • 274 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv.

1993 • 257 citations

Natural killer cell cytotoxicity of breast cancer targets is enhanced by two distinct mechanisms of antibody-dependent cellular cytotoxicity against LFA-3 and HER2/neu

1999 • 210 citations

The macrophage – a novel system to deliver gene therapy to pathological hypoxia

2000 • 208 citations

Immunohistological distribution of 5T4 antigen in normal and malignant tissues

1990 • 177 citations

The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

1996 • 161 citations

IgG Effector Mechanisms

1996 • 130 citations

A 72 kD trophoblast glycoprotein defined by a monoclonal antibody

1988 • 124 citations

Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression.

1998 • 120 citations

Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma

1994 • 117 citations

A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments

1999 • 96 citations

Ex vivo manipulation of hematopoietic stem cells for transplantation: the potential role of amifostine.

1999 • 93 citations

The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomas

1998 • 90 citations

Phase I/II trial of131I-MN-14 F(ab)2 anti-carcinoembryonic antigen monoclonal antibody in the treatment of patients with metastatic medullary thyroid carcinoma

1999 • 84 citations

5T4 oncofetal antigen expression in ovarian carcinoma

1995 • 84 citations

Phase I radioimmunotherapy trial with iodine-131-CC49 in metastatic colon carcinoma.

1995 • 77 citations

Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.

1999 • 73 citations

The expression of 5T4 antigen in colorectal and gastric carcinoma

1992 • 72 citations

Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein. An antigen associated with metastasis contains leucine-rich repeats.

1994 • 72 citations

Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy

2000 • 72 citations

Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy

2000 • 70 citations

Isolation and characterization of 5T4, a tumour‐associated antigen

1990 • 65 citations

Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen

2001 • 63 citations

High-affinity recombinant phage antibodies to the pan-carcinoma marker epithelial glycoprotein-2 for tumour targeting

1998 • 58 citations

Antibody-targeted therapy for myeloid leukemia.

1999 • 55 citations

A neoadjuvant clinical trial in colorectal cancer patients of the human anti-idiotypic antibody 105AD7, which mimics CD55.

2000 • 53 citations

Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.

1998 • 51 citations

The human antimouse immunoglobulin response and the anti-idiotypic network have no influence on clinical outcome in patients with minimal residual colorectal cancer treated with monoclonal antibody CO17-1A.

2000 • 48 citations

Treatment of B-cell non-Hodgkin's lymphoma with anti CD 20 monoclonal antibody Rituximab

2001 • 46 citations

Construction and Characterization of a Triple-Recombinant Vaccinia Virus Encoding B7-1, Interleukin 12, and a Model Tumor Antigen

1998 • 45 citations

Regulation of Fc gamma receptor expression and phagocytosis of a human monoblast cell line U937. Participation of cAMP and protein kinase C in the effects of IFN-gamma and phorbol ester.

1989 • 43 citations

Adenoviral delivery of B7–1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells

1998 • 42 citations

Comparison of tumor targeting in nude mice by murine monoclonal antibodies directed against different human colorectal cancer antigens.

1990 • 31 citations

IgG Effector Mechanisms

2015 • 29 citations

Isolation of a high affinity scFv from a monoclonal antibody recognising the oncofoetal antigen 5T4

2000 • 28 citations

Recombinant adenoviral delivery for in vivo expression of scFv antibody fusion proteins

1998 • 27 citations

Investigation of expression of 5T4 antigen in cervical cancer

1990 • 26 citations

Improved long-term survival for unresectable hepatocellular carcinoma (HCC) with a combination of surgery and intrahepatic arterial infusion of 131 I-anti-HCC mAb. Phase I/II clinical trials

1998 • 26 citations

Induction of multiple anti-c-erbB-2 specificities accompanies a classical idiotypic cascade following 2B1 bispecific monoclonal antibody treatment

1997 • 19 citations

DIFFERENT DOSE REGIMENS OF THE MOUSE MONOCLONAL-ANTIBODY 17-1A FOR THERAPY OF PATIENTS WITH METASTATIC COLORECTAL-CARCINOMA

1995 • 15 citations

Self-reactive antibody expression by human carcinoma cells engineered with monoclonal antibody genes.

1993 • 10 citations