Circulatory Disturbances in Multiple Systems Organ Failure

Profound but Reversible Myocardial Depression in Patients with Septic Shock

1984 • 1,518 citations

[Multiple organ failure syndrome].

1988 • 795 citations

Multiple System Organ Failure

1980 • 751 citations

Pulmonary Hypertension in Severe Acute Respiratory Failure

1977 • 729 citations

Influence of Positive End-Expiratory Pressure on Left Ventricular Performance

1981 • 673 citations

Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome

1983 • 654 citations

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

1985 • 620 citations

Control of resistance, exchange, and capacitance functions in the peripheral circulation.

1968 • 570 citations

The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients

1987 • 559 citations

The pathophysiology of failure in acute right ventricular hypertension: hemodynamic and biochemical correlations.

1981 • 545 citations

Serial cardiovascular variables in survivors and nonsurvivors of human septic shock

1987 • 502 citations

The coronary circulation in human septic shock.

1986 • 466 citations

Patterns Of Septic Shock In Man—a Detailed Study Of 56 Patients

1967 • 384 citations

Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

1987 • 370 citations

Hypermetabolism, organ failure, and metabolic support.

1987 • 362 citations

Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia

1988 • 338 citations

The concept of a critical oxygen delivery

1987 • 335 citations

Effect of sepsis on tissue adenine nucleotide levels.

1979 • 329 citations

The role of vasodilator therapy in heart failure

1977 • 316 citations

Misled by the Wedge?

1986 • 231 citations

Splanchnic and total body oxygen consumption differences in septic and injured patients.

1987 • 229 citations

Prostaglandin E1 and Survival in Patients with the Adult Respiratory Distress Syndrome

1986 • 221 citations

Pathological supply dependence of O2 uptake during bacteremia in dogs

1987 • 218 citations

Determinants of Organ Malfunction or Death in Patients With Intra-abdominal Sepsis

1983 • 216 citations

Adult respiratory distress syndrome. Prognosis after onset.

1985 • 207 citations

Optimum left heart filling pressure during fluid resuscitation of patients with hypovolemic and septic shock

1983 • 199 citations

Ischemic Areas in Perfused Rat Hearts: Measurement by NADH Fluorescence Photography

1976 • 193 citations

Effect of Epinephrine on Pressure, Flow, and Volume Relationships in the Systemic Circulation of Dogs

1974 • 188 citations

Right ventricular performance in septic shock: A combined radionuclide and hemodynamic study

1984 • 185 citations

Pulmonary Hypertension in Sepsis

1978 • 177 citations

Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis

1984 • 171 citations

Oxygen supply to the tissues during limited normovolemic hemodilution

1973 • 162 citations

PLASMA THROMBOXANE CONCENTRATIONS ARE RAISED IN PATIENTS DYING WITH SEPTIC SHOCK

1982 • 160 citations

Oxygen Delivery in Critically III Patients

1985 • 160 citations

The systemic septic response

1980 • 154 citations

The hemodynamic effect of rapid fluid infusion in critically ill patients.

1981 • 136 citations

Spectrum of cardiovascular function during gram-negative sepsis

1981 • 135 citations

Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock

1986 • 135 citations

Positive end-expiratory pressure therapy in adults with special reference to acute lung injury

1984 • 129 citations

Pathogenesis of hypotension in septic shock

1988 • 124 citations

Pharmacologic manipulation of the peripheral vasculature in shock: clinical and experimental approaches.

1986 • 123 citations

Biventricular Function in the Adult Respiratory Distress Syndrome

1983 • 120 citations

Unsuspected Right Ventricular Dysfunction in Shock and Sepsis

1983 • 120 citations

Metabolism During the Postinjury Period

1969 • 120 citations

Adult respiratory distress syndrome: Prognosis after onset

1986 • 117 citations

Persistence of coronary vasodilator reserve despite functionally significant flow reduction

1985 • 109 citations

The Effect of Pulmonary Hypertension on Systolic Function of the Right Ventricle

1983 • 108 citations

Sequential Cardiorespiratory Patterns Associated with Outcome in Septic Shock

1984 • 107 citations

Regulation of tissue oxygen extraction is disturbed in adult respiratory distress syndrome.

1985 • 103 citations

Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey

1982 • 101 citations

Cardiac output in bacterial shock

1978 • 101 citations

Evidence for Adenosine Triphosphate Degradation in Critically-Ill Patients

1985 • 97 citations

Eicosanoids as mediators of ischemia and shock.

1985 • 91 citations

Local control of tissue oxygen delivery and its contribution to the regulation of cardiac output

1973 • 88 citations

Prostacyclin Reversal of Lethal Endotoxemia in Dogs

1981 • 88 citations

Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock.

1980 • 86 citations

Inhibition of Prostaglandin Synthesis Restores Normal Hemodynamics in Canine Hyperdynamic Sepsis

1984 • 84 citations

Cardiovascular performance with E. coli challenges in a canine model of human sepsis

1988 • 83 citations

Hepatic Perfusion and Splanchnic Oxygen Consumption in Patients Postinjury

1983 • 81 citations

Anatomic and Cardiopulmonary Responses to Trauma with Associated Blunt Chest Injury

1981 • 79 citations

Elevated plasma 6-keto-prostaglandin F1α in patients in septic shock

1985 • 78 citations

Altered Renal Homeostasis With Acute Sepsis

1973 • 78 citations

Effective organ blood flow and bioenergy status in murine peritonitis.

1986 • 74 citations

Multiple Systems Organ Failure

1981 • 70 citations

Circulatory mechanisms of shock and their mediators

1987 • 69 citations

Clinical and Hemodynamic Correlates in Pulmonary Embolism

1984 • 68 citations

Skeletal Microcirculatory Responses to Hyperdynamic Escherichia coli Sepsis in Unanesthetized Rats

1987 • 67 citations

Capillary muscle blood flow in human sepsis.

1975 • 63 citations

Salutary Effects of Prostacyclin in Endotoxic Shock

1980 • 61 citations

Regional blood flow during continuous low-dose endotoxin infusion.

1986 • 59 citations

Group B streptococcal sepsis in the piglet: effects of fluid therapy on venous return, organ edema, and organ blood flow.

1987 • 57 citations

Relative myocardial depression in normotensive sepsis

1989 • 57 citations

Cardiovascular determinants of the hemodynamic response to acute endotoxemia in the dog

1986 • 55 citations

Mechanisms of cardiodepression in endotoxin shock.

1979 • 54 citations

Physiology of the intestinal circulation

1985 • 54 citations

Vasomotor control: functional hyperemia and beyond.

1987 • 53 citations

Acute Lung Injury in Septic Shock

1989 • 52 citations

The Role of Arachidonic Acid Metabolites in Renal Homeostasis

1987 • 51 citations

Hepatocellular function and nutrient blood flow in experimental peritonitis.

1982 • 46 citations

Regulation of tissue oxygen extraction is disturbed in adult respiratory distress syndrome

1986 • 46 citations

Right and left ventricular performance in acute hypoxemic respiratory failure

1986 • 40 citations

The Renal Response Produced by Nonhypotensive Sepsis in a Large Animal Model

1986 • 38 citations

Systemic and regional hemodynamic changes after intraperitoneal endotoxin in rabbits: development of a new model of the clinical syndrome of hyperdynamic sepsis.

1987 • 38 citations

Peripheral lymph flow in sheep with bacterial peritonitis: evidence for increased peripheral microvascular permeability accompanying systemic sepsis.

1985 • 38 citations

Influence of Experimental Edema on Metabolically Determined Blood Flow

1974 • 36 citations

Pancreatic circulation: intrinsic regulation

1982 • 36 citations

Metabolism after trauma and in sepsis.

1986 • 33 citations

Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis.

1985 • 32 citations

Optimal hematocrit for oxygenation of canine intestine.

1982 • 31 citations

Reactive hyperemia in patients with septic conditions.

1988 • 31 citations

Endotoxin, Cellular Function, and Nutrient Blood Flow

1983 • 31 citations

Morphometric investigation of the microvascular system of pancreatic exocrine and endocrine tissue in the rat

1987 • 29 citations

The Effects of Coronary Artery Disease on Cardiac Function in Nonhypotensive Sepsis

1988 • 29 citations

Left ventricular function during chronic endotoxemia in swine

1988 • 28 citations

Cardiovascular Physiology IV

1982 • 26 citations

Effect of Injury, Sepsis, and Parenteral Nutrition on High‐Energy Phosphates in Human Liver and Muscle

1985 • 25 citations

Evidence for pancreas injury in adult respiratory distress syndrome.

1985 • 24 citations

The Protective Effect of Thromboxane Synthetase Inhibition on Renal Function in Systemic Sepsis

1989 • 23 citations

Cardiopulmonary Effects of Volume Loading of Primates in Endotoxin Shock

1974 • 20 citations

Mechanisms of endotoxin-induced impairment in Na+-Ca2+ exchange in canine myocardium

1986 • 20 citations

Alterations in Renal Perfusion and Renal Energy Charge in Murine Peritonitis

1987 • 19 citations

Myocardial Adenosine Triphosphate Levels During Early Sepsis

1983 • 19 citations

Cardiorespiratory responses to fluid administration in peritonitis

1984 • 19 citations

Regional blood flow and pulmonary thromboxane release after sublethal endotoxin infusion in sheep.

1984 • 18 citations

A high plasma prostaglandin-to-thromboxane ratio protects against renal ischemia

1988 • 17 citations

Canine biventricular performance during acute progressive pulmonary microembolization: Regional myocardial perfusion and fatty acid uptake

1987 • 13 citations

Left ventricular performance in canine endotoxin shock.

1988 • 13 citations

The critical relationship of intravascular blood volume and vascular capacitance in sepsis.

1976 • 11 citations

Imidazole and indomethacin improve hepatic perfusion in sepsis.

1987 • 11 citations

Effects of leukotrienes B4, C4, and D4 on rat mesenteric microcirculation

1987 • 10 citations

Impaired Renal Concentrating Ability During Resuscitation From Shock

1983 • 10 citations

ORGAN BLOOD FLOW IN HIGH OUTPUT NORMOTENSIVE SEPSIS

1987 • 10 citations

Increased survival in bacteremic sheep treated with ibuprofen

1986 • 9 citations

CARDIAC BETA RECEPTOR DYSFUNCTION IN AN ANIMAL MODEL OF THE “SEPSIS SYNDROME”

1987 • 9 citations

Intestinal prostacyclin and thromboxane production in irreversible hemorrhagic shock.

1987 • 8 citations

SIMILAR PATTERNS OF LEFT AND RIGHT VENTRICULAR DYSFUNCTION IN SURVIVORS AND NONSURVIVORS OF SEPTIC SHOCK IN HUMANS

1988 • 8 citations

A BIOCHEMICAL MECHANISM FOR VASODILATION IN SEPTIC SHOCK

1987 • 6 citations

THE EFFECT OF CORONARY ARTERY DISEASE ON THE BIVENTRICULAR HEMODYNAMIC RESPONSE TO HUMAN HYPERDYNAMIC SEPSIS

1986 • 5 citations

HYPERDYNAMIC SEPSIS MODIFIES THE REGIONAL VASCULAR RESPONSES TO PEEP

1988 • 4 citations

VASCULAR REACTIVITY IN THE RAT ISOLATED PERFUSED MESENTERY IS NOT AFFECTED BY PRIOR IN VIVO ADMINISTRATION OF ENDO- TOXIN

1988 • 2 citations

DETERMINATION OF RENAL BLOOD FLOW IN SEPTIC AND CRITICALLY ILL PATIENTS USING A NEWLY DESIGNED THERMODILUTION RENAL VEIN CATHETER

1987 • 2 citations

INOTROPES OR VASODILATORS TREATMENT OF AN 02 DEBT IN HYPERDYNAMIC SEPSIS

1988 • 1 citations