Impaired Presynaptic Regulation of Norepinephrine in Schizophrenia

Statistical principles in experimental design.

1962 • 27,228 citations

Presynaptic regulation of the release of catecholamines.

1980 • 1,483 citations

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization

1977 • 712 citations

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

1979 • 666 citations

Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane

1976 • 638 citations

Central α-adrenergic systems as targets for hypotensive drugs

1978 • 514 citations

Feedback Inhibition of Brain Noradrenaline Neurons by Tricyclic Antidepressants: α-Receptor Mediation

1978 • 396 citations

Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents

1976 • 378 citations

Effect of clonidine on growth hormone release in psychiatric patients and controls

1980 • 377 citations

Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkeyMacaca arctoides

1976 • 302 citations

Distinct α-noradrenergic receptors differentiated by binding and physiological relationships

1979 • 300 citations

Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain

1977 • 290 citations

Norepinephrine in Chronic Paranoid Schizophrenia: Above-Normal Levels in Limbic Forebrain

1978 • 265 citations

Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding

1979 • 264 citations

Antidopaminergic properties of yohimbine.

1980 • 205 citations

Clonidine-induced inhibition of sympathetic nerve activity: No indication for a central presynaptic or an indirect sympathomimetic mode of action

1974 • 200 citations

Schizophrenia: Elevated Cerebrospinal Fluid Norepinephrine

1980 • 199 citations

Urinary 3-Methoxy-4-Hydroxyphenylglycol Circadian Rhythm

1980 • 197 citations

The relative importance of dopaminergic and noradrenergic neuronal systems for the stimulation of locomotor activity induced by amphetamine and other drugs

1973 • 184 citations

3-Methoxy-4-Hydroxyphenethyleneglycol Production by Human Brain in Vivo

1979 • 179 citations

The determination of a brain arteriovenous difference for 3-methoxy-4-hydroxyphenethyleneglycol (MHPG)

1976 • 134 citations

Direct biochemical demonstration of two types of α-adrenoreceptor in rat brain

1978 • 122 citations

Presence of free, sulfate and glucuronide conjugated 3-methoxy-4-hydroxyphenylglycol (MHPG) in human brain, cerebrospinal fluid and plasma

1977 • 120 citations

Alterations in Motor Activity, Sleep, and Biochemistry in a Cycling Manic-Depressive Patient

1977 • 115 citations

Centrally induced reduction in sympathetic tone — A postsynaptic α-adrenoceptor-stimulating action of imidazolines

1976 • 110 citations

Noradrenergic Overactivity in Chronic Schizophrenia: Evidence Based on Cerebrospinal Fluid Noradrenaline and Cyclic Nucleotide Concentrations

1980 • 91 citations

Interactions of antipsychotic drugs with norepinephrine and cerebellar neuronal circuitry: implications for the psychobiology of psychosis.

1977 • 85 citations

3-methoxy-4-hydroxyphenethylene glycol in plasma

1974 • 84 citations

Effects of oral clonidine on plasma 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) in man: Preliminary report

1980 • 80 citations

The effect of pimozide on CSF norepinephrine in schizophrenia

1981 • 73 citations

Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine

1976 • 73 citations

Blockade by pimozide of a noradrenaline sensitive adenylate cyclase in the limbic forebrain: possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics

1975 • 70 citations

Schizophrenia: A theory

1976 • 65 citations

Propranolol in Schizophrenia

1980 • 60 citations

Reduced cyclic AMP production in the blood platelets from schizophrenic patients

1979 • 59 citations

Effect of neuroleptics on endogenous norepinephrine in rat brain

1973 • 48 citations

The onset of denervation supersensitivity.

1966 • 47 citations

Preliminary trial of the noradrenergic agonist clonidine in psychiatric patients.

1980 • 43 citations

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

1980 • 39 citations

Propranolol and Schizophrenia

1979 • 38 citations

Interaction of β-phenethylamine with dopamine and noradrenaline in the central nervous system of the rat

1976 • 34 citations

CNS site of clonidine induced hypotension: A microiontophoretic study of bulbar cardiovascular neurons

1978 • 30 citations

Locomotor stimulation by l-Dopa: Relative importance of noradrenaline receptor activation

1977 • 27 citations

Piperoxane reduces the effects of clonidine on aggression in mice and on noradrenaline dependent hypermotility in rats

1978 • 25 citations

A Preliminary Evaluation of the Sedative Effects of Catapres, a New Antihypertensive Agent, in Chronic Schizophrenic Patients

1967 • 25 citations

Regulation of neurotransmission through presynaptic receptors and other mechanisms: possible clinical relevance and therapeutic potential.

1980 • 22 citations

Modification of the receptor component of adenylate cyclase in the rat brain by phenothiazine derivatives

1974 • 20 citations

The excretion of 3-methoxy-4-hydroxymandelic acid in normal and in chronic schizophrenic male subjects Effect of reserpine and chlorpromazine

1962 • 14 citations

The hyperkinetic syndrome following long-term haloperidol treatment: Involvement of dopamine and noradrenaline

1979 • 14 citations

A Pilot Study of ST‐155 (Catapres) in Chronic Schizophrenics

1967 • 13 citations

α-Adrenoceptors and the Clinical Pharmacology of Clonidine

1980 • 6 citations

Effects of denervation on the sensitizing effect to noradrenaline induced by morphine in the vas deferens of mice treated chronically with morphine☆

1982 • 4 citations