Brain‐Derived Neurotrophic Factor, Neurotrophin‐3, and Neurotrophin‐4/5 Prevent the Death of Striatal Projection Neurons in a Rodent Model of Huntington's Disease

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

Differential loss of striatal projection neurons in Huntington disease.

1988 • 976 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1997 • 853 citations

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1999 • 641 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

A consideration of neural counting methods

1992 • 542 citations

The role of neuronal growth factors in neurodegenerative disorders of the human brain

1998 • 539 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1990 • 477 citations

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

1999 • 291 citations

BDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia

2000 • 267 citations

The NeurotroDhins BDNF, NT-3 and NT-4/5 Promote Survival and Morphological and Biochemical Differentiation of Striatal NeuronsIn Vitro

1995 • 262 citations

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

1993 • 261 citations

Widespread and Developmentally Regulated Expression of Neurotrophin‐4 mRNA in Rat Brain and Peripheral Tissues

1993 • 256 citations

Neurotrophic factor therapy for nervous system degenerative diseases

1994 • 254 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

Protection of the Neostriatum against Excitotoxic Damage by Neurotrophin-Producing, Genetically Modified Neural Stem Cells

1996 • 215 citations

Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

1994 • 212 citations

Neurotrophins Live or Let Die: Does p75NTR Decide?

1997 • 211 citations

Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions

1993 • 202 citations

TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death

1997 • 201 citations

BDN F Down‐regulates Neurotrophin Responsiveness, TrkB Protein and TrkB mRNA Levels in Cultured Rat Hippocampal Neurons

1996 • 199 citations

Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.

1996 • 199 citations

Brain-Derived Neurotrophic Factor-Mediated Protection of Striatal Neurons in an Excitotoxic Rat Model of Huntington's Disease, as Demonstrated by Adenoviral Gene Transfer

1999 • 164 citations

Differential Utilization of Trk Autophosphorylation Sites

1996 • 162 citations

Recent Advances on the Pathogenesis of Huntington's Disease

1999 • 158 citations

Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients

1995 • 150 citations

Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

1996 • 148 citations

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

1996 • 111 citations

Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons

1995 • 100 citations

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

1996 • 97 citations

Neurotrophin‐4/5 Promotes Survival and Differentiation of Rat Striatal Neurons Developing in Culture

1994 • 95 citations

Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors

1998 • 93 citations

Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins

1995 • 91 citations

Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor

1995 • 90 citations

Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage

1996 • 89 citations

BDNF Up‐Regulates TrkB Protein and Prevents the Death of CA1 Neurons Following Transient Forebrain Ischemia

1998 • 89 citations

Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro

1995 • 79 citations

Expression of Neurotrophins by Midbrain Dopaminergic Neurons

1993 • 72 citations

Effects of BDNF and NT‐4/5 on Striatonigral Neuropeptides or Nigral GABA Neurons In Vivo

1996 • 67 citations

Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo

1999 • 65 citations

Intrastriatal grafting of a GDNF‐producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo

1999 • 60 citations

Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture

1994 • 54 citations

Protective effects of neurotrophin-4/5 and transforming growth factor-α on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid

1997 • 47 citations

Intraparenchymal NGF Injections in Adult and Aged Rats Induce Long-Lasting Trk Tyrosine Phosphorylation

1996 • 36 citations

Compartmental expression of trkB receptor protein in the developing striatum

1999 • 35 citations

The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum

1999 • 35 citations

Effects of striatal excitotoxicity on Huntingtin-like immunoreactivity

1995 • 31 citations

Transcription of the Huntington disease gene during the quinolinic acid excitotoxic cascade

1995 • 19 citations

Neuroprotective Strategies Involving the Neurotrophins and Their Signaling Pathways

1998 • 7 citations

Neuroprotective Strategies Involving the Neurotrophins and Their Signaling Pathways

2003 • 2 citations