Brain-Derived Neurotrophic Factor-Mediated Protection of Striatal Neurons in an Excitotoxic Rat Model of Huntington's Disease, as Demonstrated by Adenoviral Gene Transfer

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

1998 • 1,592 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

1997 • 1,093 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1997 • 853 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

1997 • 732 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization

1984 • 652 citations

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1999 • 641 citations

Update on adenovirus and its vectors

2000 • 605 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Widespread expression of Huntington's disease gene (IT15) protein product

1995 • 516 citations

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1990 • 477 citations

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1995 • 445 citations

Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats

1999 • 418 citations

Ectopically Expressed CAG Repeats Cause Intranuclear Inclusions and a Progressive Late Onset Neurological Phenotype in the Mouse

1997 • 374 citations

Calcium and Excitotoxic Neuronal Injury

1994 • 351 citations

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

1997 • 321 citations

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease

1997 • 301 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

The NeurotroDhins BDNF, NT-3 and NT-4/5 Promote Survival and Morphological and Biochemical Differentiation of Striatal NeuronsIn Vitro

1995 • 262 citations

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models

1998 • 257 citations

Brain-Derived Neurotrophic Factor Promotes Differentiation of Striatal GABAergic Neurons

1994 • 255 citations

Immunoaffinity purification of FLAG epitope-tagged bacterial alkaline phosphatase using a novel monoclonal antibody and peptide elution.

1994 • 246 citations

Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action

1999 • 215 citations

Protection of the Neostriatum against Excitotoxic Damage by Neurotrophin-Producing, Genetically Modified Neural Stem Cells

1996 • 215 citations

Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions

1993 • 202 citations

Brain‐Derived Neurotrophic Factor, Neurotrophin‐3, and Neurotrophin‐4/5 Prevent the Death of Striatal Projection Neurons in a Rodent Model of Huntington's Disease

2000 • 192 citations

In Situ Hybridization of trkB and trkC Receptor mRNA in Rat Forebrain and Association with High‐affinity Binding of [¹²⁵I]BDNF, [¹²⁵I]NT‐4/5 and [¹²⁵I]NT‐3

1994 • 190 citations

Synaptogenesis of cultured striatal neurons in serum-free medium: a morphological and biochemical study.

1986 • 187 citations

Safety of Intrastriatal Neurotransplantation for Huntington's Disease Patients

1998 • 185 citations

Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses

1997 • 160 citations

Immunological Instability of Persistent Adenovirus Vectors in the Brain: Peripheral Exposure to Vector Leads to Renewed Inflammation, Reduced Gene Expression, and Demyelination

1996 • 154 citations

Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.

1996 • 148 citations

Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population

1997 • 117 citations

Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density

1996 • 112 citations

Prevention of motoneuron death by adenovirus-mediated neurotrophic factors

1997 • 106 citations

Neurotrophin‐4/5 Promotes Survival and Differentiation of Rat Striatal Neurons Developing in Culture

1994 • 95 citations

Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease

1997 • 85 citations

Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro

1995 • 79 citations

Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro

1997 • 79 citations

Direct Intracerebral Nerve Growth Factor Gene Transfer Using a Recombinant Adenovirus: Effect on Basal Forebrain Cholinergic Neurons during Aging

1996 • 46 citations

Prevention of apoptotic motoneuron death in vitro by neurotrophins and muscle extract

1997 • 36 citations

An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity

1996 • 25 citations

Computer Methods in Nuclei Cartography

1992 • 20 citations