Cardiomyopathies: from genetics to the prospect of treatment

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)

1999 • 4,963 citations

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies

1996 • 3,392 citations

Effect of Carvedilol on Survival in Severe Chronic Heart Failure

2001 • 3,011 citations

Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults

1995 • 2,098 citations

Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II

2000 • 1,956 citations

Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy

2000 • 1,665 citations

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

1999 • 1,318 citations

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

1999 • 1,288 citations

Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial

1996 • 1,088 citations

Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)

2000 • 1,079 citations

Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials

2000 • 1,050 citations

The Genetic Basis for Cardiomyopathy

2001 • 1,049 citations

Efficacy of Implantable Cardioverter–Defibrillators for the Prevention of Sudden Death in Patients with Hypertrophic Cardiomyopathy

2000 • 1,030 citations

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

1994 • 1,008 citations

Spectrum of Clinicopathologic Manifestations of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Multicenter Study

1997 • 968 citations

Sudden death in hypertrophic cardiomyopathy: identification of high risk patients

2000 • 960 citations

Mutations in the Genes for Cardiac Troponin T and α-Tropomyosin in Hypertrophic Cardiomyopathy

1995 • 913 citations

MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure

1997 • 831 citations

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)

2001 • 807 citations

Epidemiology of Hypertrophic Cardiomyopathy–Related Death

2000 • 781 citations

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma

2000 • 777 citations

Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy

1995 • 773 citations

Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy

1992 • 732 citations

Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy

2000 • 698 citations

Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: Morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients

1995 • 646 citations

Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984.

1989 • 621 citations

Actin Mutations in Dilated Cardiomyopathy, a Heritable Form of Heart Failure

1998 • 606 citations

Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

1996 • 586 citations

Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

1997 • 568 citations

Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy

1999 • 553 citations

Clinical Course of Hypertrophic Cardiomyopathy in a Regional United States Cohort

1999 • 544 citations

Mutations in the gamma2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

2001 • 521 citations

Assessment of Permanent Dual-Chamber Pacing as a Treatment for Drug-Refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy

1999 • 495 citations

Missense mutations in desmin associated with familial cardiac and skeletal myopathy

1998 • 489 citations

Desmin Mutation Responsible for Idiopathic Dilated Cardiomyopathy

1999 • 449 citations

Desmin Myopathy, a Skeletal Myopathy with Cardiomyopathy Caused by Mutations in the Desmin Gene

2000 • 435 citations

Frequency and Phenotypes of Familial Dilated Cardiomyopathy

1998 • 435 citations

Autosomal recessive limbgirdle muscular dystrophy, LGMD2F, is caused by a mutation in the δ–sarcoglycan gene

1996 • 422 citations

Deletion of the Dystrophin Muscle-Promoter Region Associated with X-Linked Dilated Cardiomyopathy

1993 • 413 citations

Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death

1993 • 412 citations

α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy

1999 • 394 citations

Operative treatment in hypertrophic subaortic stenosis. Techniques, and the results of pre and postoperative assessments in 83 patients.

1975 • 385 citations

Hypertrophic cardiomyopathy

1997 • 357 citations

Mutations in the human δ-sarcoglycan gene in familial and sporadic dilated cardiomyopathy

2000 • 349 citations

The heart failure epidemic: exactly how big is it?

2001 • 337 citations

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

2000 • 337 citations

Emerin deficiency at the nuclear membrane in patients with Emery-Dreif uss muscular dystrophy

1996 • 337 citations

Structural Analysis of the Titin Gene in Hypertrophic Cardiomyopathy: Identification of a Novel Disease Gene

1999 • 326 citations

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.

1994 • 289 citations

Natural History of Hypertrophic Cardiomyopathy

1995 • 265 citations

Dystrophies and heart disease

1997 • 260 citations

Mitochondrial DNA Mutations and Mitochondrial Abnormalities in Dilated Cardiomyopathy

1998 • 242 citations

Patterns of inheritance in hypertrophic cardiomyopathy: Assessment by m-mode and two-dimensional echocardiography

1984 • 233 citations

The X-Linked Gene G4.5 Is Responsible for Different Infantile Dilated Cardiomyopathies

1997 • 229 citations

Heart failure: a growing public health problem

1995 • 221 citations

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.

1995 • 218 citations

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy

1999 • 189 citations

CARDIOMYOPATHY: Diagnosis and management of dilated cardiomyopathy

2000 • 184 citations

Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.

1995 • 176 citations

Maternally inherited cardiomyopathy and hearing loss associated with a novel mutation in the mitochondrial tRNA(Lys) gene (G8363A).

1996 • 173 citations

Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: Insights into disease pathogenesis and troponin function

1998 • 172 citations

Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein.

1997 • 172 citations

Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice

1999 • 170 citations

New primary prevention trials of sudden cardiac death in patients with left ventricular dysfunction: SCD-HEFT and MADIT-II

1999 • 157 citations

Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein Metavinculin

1997 • 153 citations

Disruption of heart sarcoglycan complex and severe cardiomyopathy caused by beta sarcoglycan mutations

2000 • 137 citations

Common Variant in AMPD1 Gene Predicts Improved Clinical Outcome in Patients With Heart Failure

1999 • 128 citations

Hypertrophic Cardiomyopathy Caused by a Novel α-Tropomyosin Mutation (V95A) Is Associated With Mild Cardiac Phenotype, Abnormal Calcium Binding to Troponin, Abnormal Myosin Cycling, and Poor Prognosis

2001 • 127 citations

Spectrum and outcome of congestive heart failure in a hospitalized population

1993 • 125 citations

AT ₁ Receptor A/C ¹¹⁶⁶ Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy

1998 • 123 citations

Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated Cardiomyopathy

1999 • 109 citations

Myocardial bridging does not predict sudden death in children with hypertrophic cardiomyopathy but is associated with more severe cardiac disease

2000 • 107 citations

Clinical Features of Hypertrophic Cardiomyopathy Caused by a Lys183 Deletion Mutation in the Cardiac Troponin I Gene

2000 • 105 citations

A double-blind, placebo-controlled crossover trial of nadolol and verapamil in mild and moderately symptomatic hypertrophic cardiomyopathy

1993 • 103 citations

Blunted Cardiac Responses to Receptor Activation in Subjects With Thr164Ile β ₂ -Adrenoceptors

2001 • 97 citations

β1-Adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?

2000 • 96 citations

Dilated Cardiomyopathy and Sensorineural Hearing Loss

2000 • 91 citations

Variants of Trophic Factors and Expression of Cardiac Hypertrophy in Patients with Hypertrophic Cardiomyopathy

2000 • 84 citations

Effects of Two Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin, Asp175Asn and Glu180Gly, on Ca2+Regulation of Thin Filament Motility

1997 • 77 citations

Hypercontractile Properties of Cardiac Muscle Fibers in a Knock-in Mouse Model of Cardiac Myosin-binding Protein-C

2001 • 74 citations

Angiotensin-Converting Enzyme and Heart Chymase gene Polymorphisms in Hypertrophic Cardiomyopathy**This study was supported by a grant-in-aid from the Bundesministerium für Bildung und Forschung and the European commission grant (ERBCHBGCT 940725.

1996 • 68 citations

Pacing therapies in congestive heart failure II study

2000 • 67 citations

Role of alcohol septal ablation in treatment of obstructive hypertrophic cardiomyopathy

2000 • 66 citations

Association of nonsense mutation of dystrophin gene with disruption of sarcoglycan complex in X-linked dilated cardiomyopathy

2000 • 62 citations

Identification of a genetic risk factor for idiopathic dilated cardiomyopathy. Involvement of a polymorphism in the endothelin receptor type A gene

1999 • 61 citations

Natural history of hypertrophic cardiomyopathy

1994 • 52 citations

Angiotensinogen gene polymorphism in Japanese patients with hypertrophic cardiomyopathy

1997 • 51 citations

Arrhythmia risk stratification in idiopathic dilated cardiomyopathy based on echocardiography and 12-lead, signal-averaged, and 24-hour Holter electrocardiography

2000 • 48 citations

Transgenic rat hearts expressing a human cardiac troponin T deletion reveal diastolic dysfunction and ventricular arrhythmias

2000 • 47 citations

Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine

2000 • 37 citations

Ventricular Pacing With Premature Excitation for Treatment of Hypertensive-Cardiac Hypertrophy With Cavity-Obliteration

1999 • 25 citations

Deleted Work

1955 • 0 citations