Structure and function of the dopamine transporter

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization

1985 • 2,441 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

1997 • 906 citations

Profound neuronal plasticity in response to inactivation of the dopamine transporter

1998 • 702 citations

Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter

1998 • 622 citations

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

1991 • 587 citations

Cloning and Expression of a Cocaine-Sensitive Dopamine Transporter Complementary DNA

1991 • 584 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

1992 • 467 citations

Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants

1997 • 448 citations

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

1992 • 393 citations

Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants

1999 • 387 citations

Membrane Trafficking Regulates the Activity of the Human Dopamine Transporter

1999 • 378 citations

Protein Kinase C Activation Regulates Human Serotonin Transporters in HEK-293 Cells via Altered Cell Surface Expression

1997 • 377 citations

Cloning and functional characterization of a cocaine‐sensitive dopamine transporter

1991 • 362 citations

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

1994 • 326 citations

Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes

1997 • 298 citations

Neurotransmitter transporters as molecular targets for addictive drugs

1998 • 294 citations

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra

1997 • 290 citations

Cloning of the cocaine-sensitive bovine dopamine transporter.

1991 • 261 citations

Neurotransmitter transporters : structure, function, and regulation

2002 • 251 citations

Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium.

1994 • 237 citations

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

1992 • 222 citations

The Third Transmembrane Domain of the Serotonin Transporter Contains Residues Associated with Substrate and Cocaine Binding

1997 • 208 citations

Carrier‐Mediated Release, Transport Rates, and Charge Transfer Induced by Amphetamine, Tyramine, and Dopamine in Mammalian Cells Transfected with the Human Dopamine Transporter

1998 • 206 citations

Transmembrane Domain I Contributes to the Permeation Pathway for Serotonin and Ions in the Serotonin Transporter

1999 • 201 citations

Delineation of an endogenous zinc-binding site in the human dopamine transporter

1998 • 191 citations

Phorbol Esters Increase Dopamine Transporter Phosphorylation and Decrease Transport V_max

1997 • 187 citations

Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes.

1997 • 186 citations

Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux.

1995 • 182 citations

Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter

1998 • 173 citations

Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition.

1996 • 169 citations

Determination of External Loop Topology in the Serotonin Transporter by Site-directed Chemical Labeling

1998 • 162 citations

Regulation of the functional activity of the human dopamine transporter by protein kinase C

1997 • 161 citations

External Cysteine Residues in the Serotonin Transporter

1997 • 158 citations

Permeation and gating residues in serotonin transporter

2000 • 156 citations

The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter.

1998 • 153 citations

Release of dopamine via the human transporter.

1994 • 153 citations

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter

1998 • 148 citations

Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.

1994 • 141 citations

Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants.

1995 • 133 citations

Phorbol esters alter functions of the expressed dopamine transporter

1994 • 118 citations

Dopamine Transporter: Transmembrane Phenylalanine Mutations Can Selectively Influence Dopamine Uptake and Cocaine Analog Recognition

1999 • 115 citations

Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter

1999 • 107 citations

N‐Linked Oligosaccharides Are Required for Cell Surface Expression of the Norepinephrine Transporter but Do Not Influence Substrate or Inhibitor Recognition

1996 • 104 citations

Dopamine transporter mutants selectively enhance MPP⁺ transport

1993 • 100 citations

The Role of External Loop Regions in Serotonin Transport

1999 • 89 citations

Transport-dependent Accessibility of a Cytoplasmic Loop Cysteine in the Human Dopamine Transporter

2000 • 87 citations

Which Form of Dopamine Is the Substrate for the Human Dopamine Transporter: the Cationic or the Uncharged Species?

1999 • 84 citations

Striatal Transporter for Dopamine: Catechol Structure‐Activity Studies and Susceptibility to Chemical Modification

1994 • 74 citations

Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter

1999 • 71 citations

Dopamine Transporter Ligand Binding Domains

1996 • 71 citations

Dopamine Transporter Cysteine Mutants: Second Extracellular Loop Cysteines Are Required for Transporter Expression

1995 • 67 citations

Characterization of a recombinant human dopamine transporter in multiple cell lines.

1995 • 65 citations

Role of Protein Kinase C and Second Messengers in Regulation of the Norepinephrine Transporter

1997 • 65 citations

The Structure and Function of Norepinephrine, Dopamine, and Serotonin Transporters

1997 • 64 citations

Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping.

1995 • 61 citations

Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine

1998 • 58 citations

The Dopamine Transporter Carboxyl-terminal Tail

1996 • 57 citations

Ion Dependence of Carrier-Mediated Release in Dopamine or Norepinephrine Transporter-Transfected Cells Questions the Hypothesis of Facilitated Exchange Diffusion

1999 • 57 citations

The Reactivity of the γ-Aminobutyric Acid Transporter GAT-1 toward Sulfhydryl Reagents Is Conformationally Sensitive

1999 • 49 citations

[3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux

1998 • 48 citations

A putative model of the dopamine transporter

1994 • 47 citations

MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters

1998 • 44 citations

Cocaine Acts as an Apparent Competitive Inhibitor at the Outward-Facing Conformation of the Human Norepinephrine Transporter: Kinetic Analysis of Inward and Outward Transport

1998 • 44 citations

Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue

1999 • 41 citations

Multisubtrate mechanism for the inward transport of dopamine by the human dopamine transporter expressed in HEK cells and its inhibition by cocaine

1999 • 40 citations

Differential effect of structural modification of human dopamine transporter on the inward and outward transport of dopamine

2000 • 39 citations

Cationic modulation of human dopamine transporter: dopamine uptake and inhibition of uptake.

1999 • 39 citations

Induction by low Na⁺ or Cl⁻ of cocaine sensitive carrier‐mediated efflux of amines from cells transfected with the cloned human catecholamine transporters^†

1997 • 38 citations

IIIIIIInteraction of Na⁺, K⁺, and Cl^‐ with the Binding of Amphetamine, Octopamine, and Tyramine to the Human Dopamine Transporter

2000 • 38 citations

Translocation of dopamine and binding of 2β-carbomethoxy-3 β-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations

1995 • 37 citations

Effects of Serine Mutations in Transmembrane Domain 7 of the Human Norepinephrine Transporter on Substrate Binding and Transport

1999 • 31 citations

Species‐ and Brain Region‐Specific Dopamine Transporters: Immunological and Glycosylation Characteristics

1996 • 29 citations

Modeling of the Interaction of Na⁺ and K⁺ with theBinding of Dopamine and [³H]WIN 35,428 to the Human Dopamine Transporter

1999 • 28 citations

[18] Transport and drug binding kinetics in membrane vesicle preparation

1998 • 25 citations

Molecular cloning and functional expression of the mouse dopamine transporter

1999 • 24 citations

The Rat Serotonin Transporter: Identification of Cysteine Residues Important for Substrate Transport

1997 • 23 citations

[31] Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development

1998 • 22 citations

The effects of phosphorylation on the functional regulation of an expressed recombinant human dopamine transporter

1996 • 21 citations

Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter

1996 • 16 citations

A cognate dopamine transporter‐like activity endogenously expressed in a COS‐7 kidney‐derived cell line¹

1999 • 11 citations