Translocation of dopamine and binding of 2β-carbomethoxy-3 β-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Neurotransmitter receptor binding

1978 • 822 citations

Principles of Drug Action: The Basis of Pharmacology.

1975 • 616 citations

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

1992 • 393 citations

The kinetics of competitive radioligand binding predicted by the law of mass action.

1984 • 390 citations

Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.

1979 • 382 citations

Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior

1986 • 289 citations

Biochemical and Pharmacological Characterization of [³H]GBR 12935 Binding In Vitro to Rat Striatal Membranes: Labeling of the Dopamine Uptake Complex

1987 • 231 citations

High‐affinity binding of [¹²⁵I]RTI‐55 to dopamine and serotonin transporters in rat brain

1992 • 211 citations

A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine

1992 • 169 citations

Estimation of hormone receptor affinity by competitive displacement of labeled ligand: Effect of concentration of receptor and of labeled ligand

1975 • 166 citations

Coupling between platelet 5-hydroxytryptamine and potassium transport.

1979 • 160 citations

In vivo characterization of locally applied dopamine uptake inhibitors by striatal microdialysis

1990 • 159 citations

Principles of Drug Action. The Basis of Pharmacology

1991 • 158 citations

Comparison of the release of [3h]dopamine from isolated corpus striatum by amphetamine, fenfluramine and unlabelled dopamine

1982 • 151 citations

Kinetics and Block of Dopamine Uptake in Synaptosomes from Rat Caudate Nucleus

1990 • 150 citations

[3H]N-[1-(2-Benzo(b)thiophenyl) cycohexyl]piperidine ([3H]BTCP): a new phencyclidine analog selective for the dopamine uptake complex

1988 • 146 citations

GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine

1991 • 123 citations

High Affinity Stereospecific Binding of [³H] Cocaine in Striatum and its Relationship to the Dopamine Transporter

1987 • 120 citations

Visualizing Dopamine and Serotonin Transporters in the Human Brain with the Potent Cocaine Analogue [¹²⁵I]RTI‐55: In Vitro Binding and Autoradiographic Characterization

1994 • 115 citations

Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter

1992 • 76 citations

Comparison of characteristics of dopamine uptake and mazindol binding in mouse striatum

1989 • 69 citations

Radiolabeling of dopamine uptake sites in mouse striatum: comparison of binding sites for cocaine, mazindol, and GBR 12935

1992 • 67 citations

Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding.

1993 • 66 citations

Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist"

1993 • 61 citations

Thermodynamic analyses of the binding of substrates and uptake inhibitors on the neuronal carrier of dopamine labeled with [3H]GBR 12783 or [3H]mazindol.

1990 • 56 citations

The Neurobiology of Cocaine‐Induced Reinforcement

2007 • 53 citations

Cocaine and dopamine differentially protect [3H]mazindol binding sites from alkylation by N-ethylmaleimide

1992 • 52 citations

Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists

1993 • 52 citations

Cationic and Anionic Requirements for the Binding of 2β‐Carbomethoxy‐3β‐(4‐Fluorophenyl)[³H]tropane to the Dopamine Uptake Carrier

1993 • 45 citations

Kinetic evidence for a common binding site for substrates and inhibitors of the neuronal noradrenaline carrier

1988 • 44 citations

Binding Sites for [³H]Cocaine in Mouse Striatum and Cerebral Cortex Have Different Dissociation Kinetics

1986 • 40 citations

Modulation by dopamine of [3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3h]btcp, a phencyclidine derivative) binding to the dopamine uptake complex

1991 • 38 citations

Putative Cocaine Receptor in Striatum Is a Glycoprotein with Active Thiol Function

1989 • 37 citations

Preclinical evaluation of McN-5707 as a potential antidepressant.

1987 • 37 citations

[3H]WIN 35,428 binding to the dopamine uptake carrier. I. Effect of tonicity and buffer composition

1994 • 34 citations

Prevention by Ginkgo biloba extract (EGb 761) and trolox C of the decrease in synaptosomal dopamine or serotonin uptake following incubation

1992 • 33 citations

Ionic Requirements for the Specific Binding of [³H]GBR 12783 to a Site Associated with the Dopamine Uptake Carrier

1988 • 33 citations

GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings

1994 • 30 citations

Comparison of the properties of central and peripheral binding sites for cocaine

1982 • 23 citations

Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites

1992 • 23 citations

Synthesis and pharmacology of irreversible affinity labels as potential cocaine antagonists: aryl 1,4-dialkylpiperazines related to GBR-12783

1992 • 22 citations

[3H]WIN 35,428 binding to the dopamine uptake carrier. II. Effect of membrane fractionation procedure and freezing

1994 • 20 citations

Dopamine uptake in five structures of the brain: Comparison of rate, sodium dependence and sensitivity to cocaine

1993 • 17 citations

Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites

1993 • 15 citations

Effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel.

1991 • 14 citations

Allosteric Regulation by Sodium of the Binding of [³H]Cocaine and [³H]GBR 12935 to Rat and Bovine Striata

1993 • 11 citations