Melatonin and Its Relation to the Immune System and Inflammation

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

1991 • 2,190 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Melatonin : a potent, endogenous hydroxyl radical scavenger

1993 • 1,673 citations

ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES¹

1958 • 1,634 citations

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

1994 • 1,099 citations

Oxidative damage in the central nervous system: protection by melatonin

1998 • 852 citations

A review of the evidence supporting melatonin's role as an antioxidant

1995 • 827 citations

Reactive oxygen species and antioxidants in inflammatory diseases

1997 • 624 citations

Pharmacological actions of melatonin in oxygen radical pathophysiology

1997 • 496 citations

Evidence for melatonin synthesis in mouse and human bone marrow cells

2000 • 377 citations

Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization

1993 • 356 citations

Identification of highly elevated levels of melatonin in bone marrow: its origin and significance

1999 • 347 citations

Evaluation of the antioxidant activity of melatonin in vitro

1996 • 341 citations

Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence

1993 • 329 citations

A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation

1998 • 322 citations

Melatonin is a scavenger of peroxynitrite

1997 • 320 citations

Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

2000 • 282 citations

On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*

1995 • 266 citations

High physiological levels of melatonin in the bile of mammals

1999 • 237 citations

Free Radical Involvement in Aging

1993 • 226 citations

Maternal‐fetal transfer of melatonin in pregnant women near term

1998 • 221 citations

Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin.

1996 • 219 citations

Comparative Physiology: Pineal Gland

1973 • 213 citations

Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver

1994 • 190 citations

Action Spectra, Dose‐Response Relationships, and Temporal Aspects of Light's Effects on the Pineal Gland

1985 • 179 citations

A Brief Survey of Pineal Gland-Immune System Interrelationships

1992 • 175 citations

The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B.

1995 • 162 citations

EFFECT OF MELATONIN ON NF‐κB DNA‐BINDING ACTIVITY IN THE RAT SPLEEN

1996 • 132 citations

Reaction of Peroxynitrite with Melatonin: A Mechanistic Study

1999 • 112 citations

High‐affinity binding of melatonin by human circulating T lymphocytes (CD4 ⁺ )

1995 • 101 citations

Melatonin in the Context of the Free Radical Theory of Aginga

1996 • 94 citations

Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation

1996 • 92 citations

Protective effect of melatonin in a non‐septic shock model induced by zymosan in the rat

1998 • 65 citations

Regulation of prostaglandin production in carrageenan‐induced pleurisy melatonin

1999 • 53 citations

ROLE OF MELATONIN IN REDUCTION OF LIPID PEROXIDATION AND PEROXYNITRITE FORMATION IN NON-SEPTIC SHOCK INDUCED BY ZYMOSAN

1999 • 51 citations

A molecular perspective of the genetic relationships of G‐protein coupled melatonin receptor subtypes

1996 • 38 citations

Mechanisms of Action of Melatonin on the Human Immune System. Membrane versus Nuclear Receptors

1997 • 3 citations

Expression of Membrane Melatonin Receptor mRNA in Rat Thymus and Spleen

1997 • 3 citations

Association of Melatonin with Nuclear Grade and Estrogen Receptor Status in Human Breast Cancer

1997 • 1 citations