Evaluation of white matter integrity in ex vivo brains of amyloid plaque-bearing APPsw transgenic mice using magnetic resonance diffusion tensor imaging

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

The basis of anisotropic water diffusion in the nervous system – a technical review

2002 • 4,349 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water

2002 • 2,506 citations

Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia

2003 • 1,674 citations

Demyelination increases radial diffusivity in corpus callosum of mouse brain

2005 • 1,593 citations

Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging

1999 • 1,398 citations

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1999 • 1,384 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

2001 • 990 citations

Differential Vulnerability of Anterior White Matter in Nondemented Aging with Minimal Acceleration in Dementia of the Alzheimer Type: Evidence from Diffusion Tensor Imaging

2004 • 650 citations

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

2000 • 642 citations

White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging

2002 • 561 citations

Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging

2000 • 470 citations

White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging

1999 • 409 citations

19F and 1H MRI detection of amyloid β plaques in vivo

2005 • 331 citations

Deciphering the Genetic Basis of Alzheimer's Disease

2002 • 292 citations

Condition Number as a Measure of Noise Performance of Diffusion Tensor Data Acquisition Schemes with MRI

2000 • 291 citations

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

2003 • 276 citations

Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

2001 • 260 citations

Relative indices of water diffusion anisotropy are equivalent in live and formalin‐fixed mouse brains

2003 • 230 citations

Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging

2002 • 227 citations

Analytical Expressions for the b Matrix in NMR Diffusion Imaging and Spectroscopy

1994 • 221 citations

Direct histological validation of diffusion tensor MRI in formaldehyde-fixed myocardium

2000 • 210 citations

Formalin fixation alters water diffusion coefficient magnitude but not anisotropy in infarcted brain

2005 • 201 citations

Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI

2003 • 201 citations

Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy

2005 • 200 citations

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis

2003 • 198 citations

Corpus Callosum Atrophy Is a Possible Indicator of Region– and Cell Type–Specific Neuronal Degeneration in Alzheimer Disease

1998 • 196 citations

In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent

2004 • 196 citations

Impact of White Matter Changes on Clinical Manifestation of Alzheimer’s Disease

2000 • 183 citations

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

2004 • 170 citations

Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer’s Disease: A Preliminary Study

2005 • 159 citations

Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile

2004 • 159 citations

The γ-Secretase Inhibitor N-[N-(3,5-Difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl Ester Reduces Aβ Levels in Vivo in Plasma and Cerebrospinal Fluid in Young (Plaque-Free) and Aged (Plaque-Bearing) Tg2576 Mice

2003 • 144 citations

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

2004 • 119 citations

Changes in extracellular space size and geometry in APP23 transgenic mice: A model of Alzheimer's disease

2005 • 109 citations

MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease

2004 • 106 citations

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

2004 • 106 citations

Visualization of β‐amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

2004 • 101 citations

Diffusion tensor imaging in fixed brain tissue at 7.0 T

2003 • 99 citations

In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice

2005 • 98 citations

Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer’s disease

1999 • 85 citations

Age-Dependent Impairment of Somatosensory Response in the Amyloid Precursor Protein 23 Transgenic Mouse Model of Alzheimer's Disease

2003 • 82 citations

Impaired Eyeblink Conditioning and Decreased Hippocampal Volume in PDAPP V717F Mice

2002 • 75 citations

Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease

2001 • 61 citations

Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis

2004 • 59 citations

Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice

2004 • 39 citations