Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Toll-like receptor signalling

2004 • 7,983 citations

Prions

1998 • 5,102 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

2006 • 1,564 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures

2000 • 972 citations

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large

2006 • 775 citations

Mammalian Prion Biology

2004 • 538 citations

A weak signal for strong responses: interferon-alpha/beta revisited

2001 • 471 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Triggering the Innate Antiviral Response through IRF-3 Activation

2007 • 444 citations

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

1995 • 382 citations

Neurons produce type I interferon during viral encephalitis

2006 • 250 citations

Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein

2000 • 234 citations

Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

2007 • 192 citations

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

2010 • 191 citations

Multiple signaling pathways leading to the activation of interferon regulatory factor 3

2002 • 148 citations

Postexposure prophylaxis against prion disease with a stimulator of innate immunity

2002 • 138 citations

Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

2009 • 126 citations

Hydrated autoclave pretreatment enhancement of prion protein immunoreactivity in formalin-fixed bovine spongiform encephalopathy-affected brain

1994 • 117 citations

Activation of Interferon Regulatory Factor 3 in Response to DNA-damaging Agents

1999 • 95 citations

Prion pathogenesis in the absence of Toll‐like receptor signalling

2003 • 79 citations

New aspects of IFN‐α/β signalling in immunity, oncogenesis and bone metabolism

2003 • 78 citations

Accelerated Prion Disease in the Absence of Interleukin-10

2004 • 75 citations

CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells.

1997 • 69 citations

TLR3 and TLR4 are innate antiviral immune receptors in human microglia: Role of IRF3 in modulating antiviral and inflammatory response in the CNS

2009 • 66 citations

Early Alpha/Beta Interferon Production by Myeloid Dendritic Cells in Response to UV-Inactivated Virus Requires Viral Entry and Interferon Regulatory Factor 3 but Not MyD88

2005 • 66 citations

Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels

2009 • 64 citations

Reciprocal Interference Between Specific CJD and Scrapie Agents in Neural Cell Cultures

2005 • 59 citations

Prion Strain-Dependent Differences in Conversion of Mutant Prion Proteins in Cell Culture

2006 • 54 citations

Detection of PrP in extraneural tissues

2000 • 52 citations

Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

2008 • 50 citations

Migration of dendritic cells into the brain in a mouse model of prion disease

2005 • 47 citations

Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice

2002 • 44 citations

Molecular biology of prions

2002 • 41 citations

Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease

2004 • 41 citations

Biological and Biochemical Characteristics of Prion Strains Conserved in Persistently Infected Cell Cultures

2005 • 39 citations

Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene

2000 • 33 citations

Failure of Interferon to Modify Scrapie in the Mouse

1969 • 26 citations

Interferon System in Mice Infected with the Scrapie Agent

1972 • 19 citations

Failure to Modify Scrapie in Mice by Administration of Interferon or Anti-interferon Globulin

1983 • 17 citations

Immunohistochemical Comparison of Anti-prion Protein (PrP) Antibodies in the CNS of Mice Infected with Scrapie

2003 • 9 citations

Characterization of a novel isoform of murine interferon regulatory factor 3

2008 • 6 citations

DNA Damaging Agents

1996 • 2 citations