Triggering the Innate Antiviral Response through IRF-3 Activation

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 • 2,329 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 • 2,116 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

Innate immune recognition of viral infection

2006 • 1,790 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

Plasmacytoid dendritic cells in immunity

2004 • 1,645 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

2006 • 1,564 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 • 1,292 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 • 947 citations

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

2006 • 926 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

2006 • 700 citations

Deciphering the Transcriptional Histone Acetylation Code for a Human Gene

2002 • 631 citations

The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses

2006 • 588 citations

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

2004 • 563 citations

Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

1998 • 546 citations

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

2003 • 524 citations

Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes

2002 • 510 citations

Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons

2006 • 500 citations

Essential role of IPS-1 in innate immune responses against RNA viruses

2006 • 483 citations

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

1995 • 382 citations

Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection

2004 • 380 citations

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

2000 • 365 citations

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

2004 • 355 citations

Enhanceosomes

2001 • 344 citations

Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15

2006 • 337 citations

Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity

2007 • 326 citations

Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

1999 • 319 citations

Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

1998 • 295 citations

Negative regulation of interferon-regulatory factor 3–dependent innate antiviral response by the prolyl isomerase Pin1

2006 • 293 citations

RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2

2006 • 287 citations

Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

2000 • 274 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection

2000 • 233 citations

Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection

2004 • 217 citations

Negative Regulation of the Retinoic Acid-inducible Gene I-induced Antiviral State by the Ubiquitin-editing Protein A20

2005 • 212 citations

A Comprehensive View of Regulation of Gene Expression by Double-stranded RNA-mediated Cell Signaling

2001 • 212 citations

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

2000 • 206 citations

Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

2003 • 205 citations

Nucleosome Sliding via TBP DNA Binding In Vivo

2001 • 195 citations

Activation of TBK1 and IKKε Kinases by Vesicular Stomatitis Virus Infection and the Role of Viral Ribonucleoprotein in the Development of Interferon Antiviral Immunity

2004 • 181 citations

A20 Is a Negative Regulator of IFN Regulatory Factor 3 Signaling

2005 • 179 citations

Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene

2000 • 160 citations

X-ray crystal structure of IRF-3 and its functional implications

2003 • 152 citations

Crystal Structure of IRF-3 in Complex with CBP

2005 • 124 citations

IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli

2003 • 114 citations

Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-κB, and Interferon but Not Toll-Like Receptor 3

2005 • 107 citations

Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages

2006 • 85 citations

Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation

2006 • 85 citations

Regulatory Serine Residues Mediate Phosphorylation-dependent and Phosphorylation-independent Activation of Interferon Regulatory Factor 7

2005 • 68 citations

Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK∈

2005 • 37 citations