Arisugacins, selective acetylcholinesterase inhibitors of microbial origin

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

APRIORITY

1961 • 1,293 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

1996 • 341 citations

Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds

1995 • 323 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

1986 • 251 citations

Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease

1982 • 239 citations

Health Care of the Elderly

1985 • 219 citations

Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients

1996 • 197 citations

Serotonin Receptor Changes in Dementia of the Alzheimer Type

1984 • 194 citations

Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.

1981 • 186 citations

Tacrine

1995 • 168 citations

The cholinesterases

1991 • 162 citations

Rational Automatic Search Method for Stable Docking Models of Protein and Ligand

1994 • 129 citations

9-Amino-1,2,3,4-tetrahydroacridin-1-ols. Synthesis and evaluation as potential Alzheimer's disease therapeutics

1989 • 103 citations

Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease

1990 • 94 citations

Territrems, tremorgenic mycotoxins of Aspergillus terreus

1979 • 89 citations

In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers

1991 • 86 citations

Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial

1994 • 82 citations

Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. FO-4259. I. Screening, Taxonomy, Fermentation, Isolation and Biological Activity.

1996 • 70 citations

Tacrine as a Treatment for Alzheimer's Dementia

1991 • 69 citations

Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus

1984 • 66 citations

Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory in rats.

1989 • 61 citations

Choline chloride treatment of memory deficits in the elderly

1979 • 56 citations

Insecticidal organophosphates: Nature made them first

1987 • 56 citations

The structure of cyclopenin and cyclopenol, metabolic products from westling and westling

1963 • 54 citations

Dementia: The neurochemical basis of putative transmitter orientated therapy

1991 • 52 citations

Heterogeneity of muscarinic autoreceptors and heteroreceptors in the rat brain: effects of a novel M1 agonist, AF102B

1988 • 52 citations

Biosynthesis of Pyripyropene A

1996 • 47 citations

Cholinergic improvement of a naturally-occurring memory deficit in the young rat

1996 • 45 citations

Central Cholinergic Agents. 6. Synthesis and Evaluation of 3-[1-(Phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)- 1-propanones and Their Analogs as Central Selective Acetylcholinesterase Inhibitors

1994 • 38 citations

Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954

1990 • 37 citations

Nmr Assignments of Territrems A, B, and C and the Structure of MB₂, the Major Metabolite of Territrem B by Rat Liver Microsomal Fraction

1992 • 36 citations

Acetylcholinesterase Inhibition by Territrem B Derivatives

1995 • 36 citations

Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. F0-4259. II. Structure Elucidation.

1996 • 34 citations

Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea

1992 • 26 citations

X-Ray crystal structure of oxalicine A, a novel alkaloid from Penicillium oxalicum

1989 • 25 citations

Pharmacological and Biochemical Assessment of SM-10888, a Novel Cholinesterase Inhibitor

1990 • 18 citations

Effects of amiridin on ambulatory activity and discrete shuttle avoidance response in mice.

1986 • 17 citations

Physostigmine and N8-norphysostigmine, insecticidal compounds, from Streptomyces sp.

1986 • 15 citations

Effects of territrem-B on cholinergic responses of snail neuron

1993 • 13 citations

Physostigmine and N8- Norphysostigmine, Insecticidal Compounds, fromStreptomycessp.

1986 • 9 citations

A CHOLINESTERASE INHIBITOR PRODUCED BY ASPERGILLUS TERREUS

1974 • 8 citations

Effects of MKC-2 31, a novel choline uptake enhancer, on AF64A-induced reduction of high affinity choline uptake and impairment of water maze learning in rats.

1993 • 7 citations

[Lactacystin: a tool for elucidation of proteasome functions].

1996 • 5 citations

A butyrylcholinesterase inhibitor produced by Penicillium sp. No. C-81 and its identity with mycelianamide.

1976 • 4 citations

Miticidal Antibiotics C-8030 B,C,D, and Physostigmine Produced by Streptomyces pseudogriseolus Subsp.iriomotensis Subsp.nov.

1981 • 3 citations

X-ray crystal structure of oxalicine A, A novel alkaloid from Penicillium cyclopium

1989 • 3 citations

プロテアソ-ム機能解明への鍵,ラクタシスチン

1996 • 1 citations