Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats

Statistical principles in experimental design.

1962 • 27,228 citations

Treating tobacco use and dependence-Clinical practice guideline

2000 • 3,721 citations

Treating Tobacco Use and Dependence

2008 • 2,821 citations

Signs and Symptoms of Tobacco Withdrawal

1986 • 1,623 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

A Critical Evaluation

1964 • 577 citations

Postcocaine anhedonia. An animal model of cocaine withdrawal.

1991 • 505 citations

Symptoms of Tobacco Withdrawal

1991 • 449 citations

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

2000 • 421 citations

Recent Advances in the Pharmacotherapy of Smoking

1999 • 385 citations

Decreased brain reward produced by ethanol withdrawal.

1995 • 349 citations

Relapse and maintenance issues for smoking cessation.

2000 • 338 citations

Rodent model of nicotine abstinence syndrome

1992 • 326 citations

Abuse liability of benzodiazepines.

1987 • 313 citations

Euphorigenic drugs: effects on the reward pathways of the brain.

1979 • 299 citations

Neurobiology of the nicotine withdrawal syndrome

2001 • 299 citations

Alcohol detoxification and withdrawal seizures: Clinical support for a kindling hypothesis

1988 • 286 citations

Repeated Episodes of Ethanol Withdrawal Potentiate the Severity of Subsequent Withdrawal Seizures: An Animal Model of Alcohol Withdrawal “Kindling”

1993 • 284 citations

Severity of withdrawal symptoms as a predictor of outcome of an attempt to quit smoking

1989 • 283 citations

Clinical Pharmacology of Nicotine

1986 • 278 citations

Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.

1994 • 275 citations

Commitment to abstinence and acute stress in relapse to alcohol, opiates, and nicotine.

1990 • 264 citations

Smoking withdrawal dynamics in unaided quitters.

2000 • 259 citations

Nicotine withdrawal symptoms and psychiatric disorders: findings from an epidemiologic study of young adults

1992 • 256 citations

The Neurobiology of Motivation and Reward

1985 • 255 citations

Construct validity of a self-stimulation threshold paradigm: Effects of reward and performance manipulations

1992 • 254 citations

Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat

2003 • 219 citations

Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.

2000 • 213 citations

Amphetamine and the reward system: Evidence for tolerance and post-drug depression

1976 • 203 citations

Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents

2003 • 193 citations

The tobacco withdrawal syndrome.

1979 • 190 citations

Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.

1998 • 178 citations

Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.

1997 • 174 citations

Nicotine dependence

2001 • 170 citations

An investigation of self-efficacy, partner support and daily stresses as predictors of relapse to smoking in self-quitters

2003 • 170 citations

Predictors of initial smoking cessation and relapse through the first 2 years of the Lung Health Study.

1995 • 155 citations

Abstinence effects as predictors of 28-day relapse in smokers

1996 • 153 citations

A digest of memory phenomena for addiction research

1994 • 152 citations

Classification and prediction of smoking relapse episodes: An exploration of individual differences.

1988 • 151 citations

Baseline factors associated with smoking cessation and relapse

1991 • 151 citations

Pre-abstinence smoke intake and smoking motivation as predictors of severity of cigarette withdrawal symptoms

1985 • 149 citations

Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

2002 • 144 citations

Cigarette withdrawal symptoms in adolescent smokers

1986 • 143 citations

Comparative Psychophysiological Studies of Alcoholic and Nonalcoholic Subjects Undergoing Experimentally Induced Ethanol Intoxication

1966 • 138 citations

Effect of Nicotine Replacement on the Cigarette Withdrawal Syndrome

1984 • 134 citations

Nicotine replacement: ten-week effects on tobacco withdrawal symptoms

1989 • 124 citations

Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds

1995 • 117 citations

Reports of smoking withdrawal symptoms over a 21 day period of abstinence

1985 • 117 citations

Predictors and Reasons for Relapse in Smoking Cessation with Nicotine and Placebo Patches

1993 • 116 citations

Who will relapse? Symptoms of nicotine dependence predict long-term relapse after smoking cessation.

1992 • 114 citations

The tobacco withdrawal syndrome in unaided quitters

1991 • 111 citations

Predictors of smoking cessation and maintenance

1998 • 106 citations

Circumstances surrounding relapse in a group of recent exsmokers

1985 • 104 citations

Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats

2000 • 103 citations

Nicotine Gum to Help Stop Smoking

1984 • 100 citations

Cigarette smoking prevalence, cessation and relapse

1998 • 99 citations

Desmethylimipramine attenuates cocaine withdrawal in rats

1992 • 96 citations

Effects of chronic amphetamine or reserpine on self-stimulation responding: Animal model of depression?

1980 • 96 citations

Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs

1999 • 96 citations

Relapse Prevention for Smoking Cessation: Review and Evaluation of Concepts and Interventions

1994 • 88 citations

Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes

1996 • 84 citations

Prospective study of factors influencing the development of craving associated with smoking cessation

1991 • 81 citations

Smoking withdrawal dynamics in unaided quitters.

2000 • 79 citations

Nicotine Skin Patch Treatment Increases Abstinence, Decreases Withdrawal Symptoms, and Attenuates Rewarding Effects of Smoking

1994 • 77 citations

Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.

1992 • 77 citations

Role of Adenosine A2 Receptors in Brain Stimulation Reward under Baseline Conditions and during Cocaine Withdrawal in Rats

1999 • 75 citations

Preventing Relapse in the Treatment of Nicotine Addiction: Current Issues and Future Directions

1992 • 74 citations

Subject characteristics and long term post-program smoking cessation

1988 • 70 citations

Withdrawal from Chronic Phencyclidine Treatment Induces Long-Lasting Depression in Brain Reward Function

2002 • 70 citations

Physical Dependence on Ethanol During Multiple Intoxication and Withdrawal Episodes in the Rat: Evidence of a Potentiation

1984 • 69 citations

Clinical conditions in alcoholics during long-term abstinence: A descriptive, longitudinal treatment study

1985 • 68 citations

Smoking cessation during previous year among adults--United States, 1990 and 1991.

1993 • 66 citations

Physical Dependence on Nicotine in Gum

1986 • 64 citations

Response sensitization and depression following long-term amphetamine treatment in a self-stimulation paradigm

1980 • 64 citations

Potentiation of ethanol withdrawal by prior dependence

1979 • 64 citations

The influence of heroin dose and route of administration on the severity of the opiate withdrawal syndrome

1999 • 61 citations

The effect of repeated withdrawal episodes on subsequent withdrawal severity in ethanol-treated rats

1989 • 53 citations

Effects of withdrawal from long-term nicotine gum use

1985 • 48 citations

Time-Dependent Alterations in ICSS Thresholds Associated With Repeated Amphetamine Administrations

2000 • 46 citations

Inter-species consistency in the behavioural pharmacology of nicotine dependence

1999 • 44 citations

Smoking relapse: the role of pharmacological and behavioral factors.

1988 • 39 citations

Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine

2003 • 34 citations

Smoking Topography in a Nonlaboratory Environment

1987 • 34 citations

Opiate withdrawal in the neonatal rat: relationship to duration of treatment and naloxone dose

2000 • 30 citations

Effect of chronic nicotine on brain stimulation reward

1998 • 27 citations

Enhanced lateral hypothalamic self-stimulation responding after chronic exposure to amphetamine

1980 • 23 citations

Clinical Aspects of Alcohol Dependence

1977 • 20 citations

Comparison of Ethanol Withdrawal Syndrome in Humans and Rats

1977 • 20 citations

Impairment of shuttlebox avoidance learning following repeated alcohol withdrawal episodes in rats

1979 • 20 citations

Effect of chronic nicotine on brain stimulation reward. II. An escalating dose regimen

1998 • 20 citations