Endocrine Disrupting Chemicals, Phthalic Acid and Nonylphenol, Activate Pregnane X Receptor-Mediated Transcription

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.

1996 • 1,076 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Nuclear receptor coactivators and corepressors

1996 • 414 citations

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

1996 • 410 citations

Research Needs for the Risk Assessment of Health and Environmental Effects of Endocrine Disruptors: A Report of the U.S. EPA-Sponsored Workshop

1996 • 313 citations

Endocrine disruptors and reproductive development: a weight-of-evidence overview

1997 • 298 citations

Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, and Xenobiotic Regulation

1999 • 196 citations

The Vitamin D Receptor Interacts with General Transcription Factor IIB

1995 • 166 citations

Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome

1996 • 165 citations

Evidence for Ligand-Dependent Intramolecular Folding of the AF-2 Domain in Vitamin D Receptor-Activated Transcription and Coactivator Interaction

1997 • 154 citations

Environmental Xenobiotics and the Antihormones Cyproterone Acetate and Spironolactone Use the Nuclear Hormone Pregnenolone X Receptor to Activate theCYP3A23Hormone Response Element

1998 • 150 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene

1999 • 115 citations

Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR

1998 • 114 citations

Molecular biology of proteasomes

1995 • 93 citations

Substrate specificities and functions of the P450 cytochromes

1990 • 79 citations

A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

1995 • 79 citations

Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

1996 • 77 citations

The N-Terminal Domain of Transcription Factor IIB Is Required for Direct Interaction with the Vitamin D Receptor and Participates in Vitamin D-Mediated Transcription

1997 • 76 citations

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif.

1996 • 74 citations

Regulation ofCYP3A9Gene Expression by Estrogen and Catalytic Studies Using Cytochrome P450 3A9 Expressed inEscherichia coli

1997 • 71 citations

Effects of Rifabutin and Rifampicin on the Pharmacokinetics of Ethinylestradiol and Norethindrone

1998 • 69 citations

Modulation of rat hepatic CYP3A by nonylphenol

1996 • 37 citations

Plasma levels of estradiol, estrone, estrone sulfate and sex hormone binding globulin in patients receiving rifampicin

1989 • 17 citations