Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

Gene structure of CYP3A4, an adult‐specific form of cytochrome P450 in human livers, and its transcriptional control

1993 • 208 citations

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes.

1992 • 197 citations

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

1993 • 182 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.

1993 • 116 citations

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

1996 • 107 citations

Functional cytochrome P4503A isoforms in human embryonic tissues: expression during organogenesis.

1994 • 80 citations

The Fetal Specific GeneCYP3A7Is Inducible by Rifampicin in Adult Human Hepatocytes in Primary Culture

1996 • 60 citations

Sequence of the 5′-Flanking Region of CYP3A5: Comparative Analysis with CYP3A4 and CYP3A7

1994 • 54 citations

Genomic organization of human fetal specific P-450IIIA7(cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5′ flanking region

1992 • 50 citations

Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa

1985 • 33 citations

Developmental expression of rabbit cytochrome P450 CYP1 A1, CYP1 A2 and CYP3 A6 genes

1991 • 31 citations

Immunochemical studies for the presence of P-450 HFLa, a form of cytochrome P-450 in human fetal livers in human hepatocellular carcinoma cells.

1989 • 8 citations