200 years of digitalis: the emerging central role of the sodium ion in the control of cardiac force

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

The dependence of calcium efflux from cardiac muscle on temperature and external ion composition

1968 • 1,024 citations

The antagonism between Ca and Na ions on the frog's heart

1958 • 497 citations

Calcium transients in aequorin-injected frog cardiac muscle

1978 • 441 citations

Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development.

1982 • 332 citations

Calcium Flux and Contractility in Guinea Pig Atria

1962 • 325 citations

Sodium-calcium ion exchange in cardiac membrane vesicles.

1979 • 307 citations

The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres

1977 • 307 citations

The subcellular basis for the mechanism of inotropic action of cardiac glycosides.

1971 • 299 citations

Free calcium in heart muscle at rest and during contraction measured with Ca2+-sensitive microelectrodes

1980 • 272 citations

Movements of Ca in frog heart ventricles at rest and during contractures

1963 • 259 citations

Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle.

1982 • 258 citations

The effect of the duration of the action potential on contraction in the mammalian heart muscle

1968 • 221 citations

Enhancement of calcium current during digitalis inotrophy in mammalian heart: positive feed‐back regulation by intracellular calcium?

1982 • 214 citations

Intracellular calcium and sodium activity in sheep heart Purkinje fibres

1982 • 210 citations

Decoupling of heart muscle cells: Correlation with increased cytoplasmic calcium activity and with changes of nexus ultrastructure

1980 • 199 citations

Sodium-calcium exchange in regulation of cardiac contractility. Evidence for an electrogenic, voltage-dependent mechanism.

1979 • 185 citations

Mechanism of action of therapeutic levels of cardiac glycosides

1980 • 184 citations

Sodium-Calcium Exchange Activity Generates a Current in Cardiac Membrane Vesicles

1980 • 180 citations

Effects of strophanthidin upon contraction and ionic exchange in rabbit ventricular myocardium: Relation to control of active state

1970 • 178 citations

The intracellular sodium activity of cardiac Purkinje fibres during inhibition and re‐activation of the Na‐K pump.

1978 • 168 citations

Effect of strophanthidin on intracellular Na ion activity and twitch tension of constantly driven canine cardiac Purkinje fibers

1982 • 165 citations

Characterization of the electrogenic sodium pump in cardiac Purkinje fibres

1980 • 160 citations

�ber den biochemischen Wirkungsmodus von Digitalis

1964 • 159 citations

The dependence of sodium pumping and tension on intracellular sodium activity in voltage‐clamped sheep Purkinje fibres.

1981 • 159 citations

Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction.

1984 • 154 citations

High-affinity ouabain binding site and low-dose positive inotropic effect in rat myocardium

1982 • 143 citations

Cardiac glycoside receptor, (Na+ + K+)ATPase activity and force of contraction in rat heart

1980 • 142 citations

The control of tonic tension by membrane potential and intracellular sodium activity in the sheep cardiac Purkinje fibre.

1983 • 130 citations

Relation between intracellular Na ion activity and tension of sheep cardiac Purkinje fibers exposed to dihydro-ouabain

1980 • 130 citations

The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres.

1984 • 125 citations

Membrane depolarization as a cause of tension development in mammalian ventricular muscle

1959 • 119 citations

An analysis of the actions of low concentrations of ouabain on membrane currents in Purkinje fibres.

1976 • 117 citations

THE INFLUENCE OF DIGITALIS GLUCOSIDES ON THE FORCE OF CONTRACTION OF MAMMALIAN CARDIAC MUSCLE

1938 • 117 citations

Inotropic effects and changes in sodium and calcium contents associated with inhibition of monovalent cation active transport by ouabain in cultured myocardial cells.

1979 • 104 citations

The effects of low sodium solutions on intracellular calcium concentration and tension in ferret ventricular muscle.

1983 • 100 citations

Is digitalis inotropy associated with enhanced slow inward calcium current?

1978 • 98 citations

Sodium-Calcium Exchange in Rabbit Heart Muscle Cells: Direct Measurement of Sarcoplasmic Ca ²⁺ Activity

1980 • 92 citations

STUDIES IN CONGESTIVE HEART FAILURE

1931 • 92 citations

Relation of sodium pump inhibition to positive inotropy at low concentrations of ouabain in rat heart muscle.

1985 • 91 citations

Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers

1979 • 91 citations

A possible molecular mechanism of the action of digitalis: ouabain action on calcium binding to sites associated with a purified sodium-potassium-activated adenosine triphosphatase from kidney.

1977 • 83 citations

The effects of membrane potential, extracellular potassium, and tetrodotoxin on the intracellular sodium ion activity of sheep cardiac muscle.

1984 • 82 citations

STIMULATION AND INHIBITION OF THE SODIUM PUMP BY CARDIOACTIVE STEROIDS IN RELATION TO THEIR BINDING SITES AND THEIR INOTROPIC EFFECT ON GUINEA‐PIG ISOLATED ATRIA

1979 • 79 citations

Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides.

1983 • 73 citations

Ouabain Effects on Cardiac Contraction, Action Potential, and Cellular Potassium

1965 • 70 citations

Voltage Dependence and Time Dependence of Contraction in Sheep Cardiac Purkinje Fibers

1971 • 70 citations

A study of the contractures induced in frog atrial trabeculae by a reduction of the bathing sodium concentration

1974 • 63 citations

The relationship among intracellular sodium activity, calcium, and strophanthidin inotropy in canine cardiac Purkinje fibers.

1984 • 55 citations

The influence of digitalis on the electrolyte and water balance of heart muscle

1940 • 48 citations

ELECTROLYTE AND WATER CONTENT OF THE VENTRICULAR MUSCULATURE OF THE HEART-LUNG PREPARATION WITH SPECIAL REFERENCE TO THE EFFECTS OF CARDIAC GLYCOSIDES

1942 • 40 citations

THE EFFECTS OF DIGILANID C IN VARYING DOSAGE UPON THE POTASSIUM AND WATER CONTENT OF RABBIT HEART MUSCLE

1939 • 39 citations

Effects of Cardiac Glycosides on Na+, K+-ATPase

1981 • 36 citations

THE INFLUENCE OF DIGOXIN ON THE POTASSIUM CONTENT OF HEART MUSCLE

1939 • 34 citations

Do Intracellular Concentrations of Potassium or Sodium Regulate the Strength of the Heart Beat?

1971 • 29 citations

The role of sodium ion in the regulation of myocardial contractility

1970 • 27 citations

Enhancement of cardiac actions of ouabain and its binding to Na+, K+-adenosine triphosphatase by increased sodium influx in isolated guinea-pig heart.

1982 • 26 citations

The relationship between the intra- and extracellular sodium activity of sheep heart Purkinje fibres during inhibition of the Na?K pump

1978 • 25 citations

Factors Affecting the Action of Lanatoside C on the Potassium Content of Isolated Perfused Guinea Pig Hearts

1954 • 21 citations

Effect of Digitoxin and Quinidine on Intracellular Electrolytes of the Rabbit Heart.

1956 • 20 citations

Changes in the sodium, potassium and chloride of rabbit auricles treated with ouabain

1962 • 20 citations

Changes in myocardial Na and K content during the development of cardiac glycoside inotropy

1979 • 16 citations

Effect of Ouabain in Therapeutic Concentrations on K+ Exchange and Contraction of Human and Rabbit Myocardium

1979 • 14 citations