High- and low-dose superoxide dismutase plus catalase does not reduce myocardial infarct size in a subhuman primate model

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction

1987 • 508 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

"Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow.

1989 • 209 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Free Radicals: Their Involvement in Disease Processes

1990 • 160 citations

Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1990 • 157 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs.

1988 • 112 citations

The mechanism of mannitol in reducing ischemic injury: hyperosmolarity or hydroxyl scavenger?

1984 • 107 citations

Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model

1986 • 91 citations

Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: a demonstration of myocardial salvage.

1989 • 79 citations

Free radicals and myocardial protection: A surgical viewpoint

1989 • 72 citations

Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart

1989 • 64 citations

Defining the anatomic perfusion bed of an occluded coronary artery and the region at risk to infarction

1981 • 61 citations

Failure of nifedipine therapy to reduce myocardial infarct size in the baboon

1982 • 52 citations

Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs.

1990 • 44 citations

Effect of human recombinant superoxide dismutase on canine myocardial infarction

1990 • 36 citations

Quantitative assessment of infarct size reduction by coronary venous retroperfusion in baboons

1982 • 30 citations

Superoxide dismutase conjugated to polyethylene glycol fails to limit myocardial infarct size after 30 min ischemia followed by 72h of reperfusion in the rabbit

1991 • 26 citations

Quantitative effect of early coronary artery reperfusion in baboons. Extent of salvage of the perfusion bed of an occluded artery.

1982 • 26 citations

Effect of superoxide dismutase on infarct size and postischemic recovery of myocardial contractility and metabolism in dogs

1991 • 23 citations

Polyethylene glycol-conjugated superoxide dismutase attenuates reperfusion injury when administered twenty-four hours before ischemia

1992 • 6 citations