Superoxide dismutase conjugated to polyethylene glycol fails to limit myocardial infarct size after 30 min ischemia followed by 72h of reperfusion in the rabbit

Superoxide Dismutase

1969 • 12,578 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction, and improved survival. Should the paradigm be expanded?

1989 • 560 citations

A Prospective Randomized Clinical Trial of Intracoronary Streptokinase versus Coronary Angioplasty for Acute Myocardial Infarction

1986 • 510 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

The mechanism of the tetrazolium reaction in identifying experimental myocardial infarction

1981 • 232 citations

"Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow.

1989 • 209 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Extracellular superoxide dismutase in the vascular system of mammals.

1988 • 196 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Thrombolytic therapy in patients with acute myocardial infarction.

1985 • 160 citations

The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans

1987 • 133 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs.

1988 • 112 citations

Can superoxide dismutase alter myocardial infarct size?

1989 • 105 citations

The role of xanthine oxidase during myocardial ischemia in several species including man

1988 • 93 citations

Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model

1986 • 91 citations

Sustained Limitation by Superoxide Dismutase of Canine Myocardial Injury Due to Regional Ischemia Followed by Reperfusion

1988 • 76 citations

Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium

1986 • 68 citations

Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart

1989 • 64 citations

Interstitial equilibration of superoxide dismutase correlates with its protective effect in the isolated rabbit heart

1991 • 57 citations

Species variation in myocardial anoxic enzyme release, glucose protection and reoxygenation damage

1976 • 38 citations

Effect of superoxide dismutase plus catalase on myocardial infarct size in rabbits.

1988 • 29 citations

Effects of polyoxyethylene-modified superoxide dismutase on reperfusion induced arrhythmias in isolated rat and guinea-pig hearts

1989 • 12 citations